http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Bolbecker, Amanda R. (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Disrupted Modular Architecture of Cerebellum in Schizophrenia: A Graph Theoretic Analysis
Kim, Dae-Jin,Kent, Jerillyn S.,Bolbecker, Amanda R.,Sporns, Olaf,Cheng, Hu,Newman, Sharlene D.,Puce, Aina,O’Donnell, Brian F.,Hetrick, William P. Oxford University Press 2014 Schizophrenia bulletin Vol.40 No.6
<P>Recent studies of schizophrenia have revealed cognitive and memory deficits that are accompanied by disruptions of neuronal connectivity in cortical and subcortical brain regions. More recently, alterations of topological organization of structural networks in schizophrenia are also being identified using graph theoretical analysis. However, the role of the cerebellum in this network structure remains largely unknown. In this study, global network measures obtained from diffusion tensor imaging were computed in the cerebella of 25 patients with schizophrenia and 36 healthy volunteers. While cerebellar global network characteristics were slightly altered in schizophrenia patients compared with healthy controls, the patients showed a retained small-world network organization. The modular architecture, however, was changed mainly in crus II. Furthermore, schizophrenia patients had reduced correlations between modularity and microstructural integrity, as measured by fractional anisotropy (FA) in lobules I–IV and X. Finally, FA alterations were significantly correlated with the Positive and Negative Syndrome Scale symptom scores in schizophrenia patients. Taken together, our data suggest that schizophrenia patients have altered network architecture in the cerebellum with reduced local microstructural connectivity and that cerebellar structural abnormalities are associated symptoms of the disorder.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
