Inhibitory Effects of EGCG on the Dopaminergic Neurons

Tag-Heo,Sujeong Jang,Song-Hee Kim,Han-Seong Jeong,Jong-Seong Park 대한의생명과학회 2009 Biomedical Science Letters Vol.15 No.2

This study was designed to investigate the effects of high concentration of (-)-epigallocatechin-3-gallate (EGCG) on the neuronal activity of rat substantia nigra dopaminergic neurons. Sprague-Dawley rats aged 14 to 16 days were decapitated under ether anesthesia. After treatment with pronase and thermolysin, the dissociated dopaminergic neurons were transferred into a chamber on an inverted microscope. Spontaneous action potentials and potassium currents were recorded by standard patch-clamp techniques under current and voltage-clamp modes respectively. 18 dopaminergic neurons (80%) revealed inhibitory responses to 40 and 100 μM of EGCG and 4 neurons (20%) did not respond to EGCG. The spike frequency and resting membrane potential of these cells were decreased by EGCG. The amplitude of afterhyperpolarization was increased by EGCG. Whole potassium currents of dopaminergic neurons were increased by EGCG (n=10). These experimental results suggest that high concentration EGCG decreases the neuronal activity of the dopaminergic neurons by altering the resting membrane potential and afterhyperpolarization.

의식이 명료한 경증 두부 외상환자에서 뇌 전산화단층촬영의 의의

허탁,김성근,민용일 大韓應急醫學會 1997 대한응급의학회지 Vol.8 No.1

A standardized approch to serious head injury employing immediate CT scanning and aggressive medical and surgical therapy has improved outcomes in cases of intracranial lesions. Unfortunately, there is less agreement on how patients with mild head injury should be handled when first seen in an emergency department setting. The ideal policy in mild head injury would be diagnosis or rule-out intracranial lesions as quickly as possible. We reviewed the records of 126 mild head injury patients admitted during 6-month period to the Chonnam University Hospital to identify a group of mild head injury patients having lesions on brain CT scanning and to investigate the risk factors affecting abnormal lesions on brain CT scanning. All patients had alert mental status without neurological deficit and signs of skull fracture. Routine brain CT scans were obtained on all patients. Fifteen patients(12%) had 17 lesions on brain CT scans. Three patients needed surgery for their intracranial lesions. The initial Glasgow Coma Scale(GCS) was 15 in 107 patients and 14 in 19 patients. The incidence of abnormal brain CT lesions for each GCS was 9% in 15 and 26% in 14. The common symptoms of patients who had abnormal brain CT lesions were headache in 7(47%) cases, loss of consciousness in 7(47%) cases, amnesia in 4(27%) cases, dizziness in 4(27%) cases, vomiting in 3(20%) cases, and lethargy in 3(20%) cases. These data suggest that early brain CT scanning is necessary in alert patients who have GCS in 14, headache, loss of consciousness, amnesia, dizziness, vomiting, or lethargy following mild head injury.

자발성 뇌지주막하출혈 환자에서 극초기 재출혈에 영향을 미치는 위험인자에 관한 분석

허 탁,민용일,윤한덕 대한응급의학회 1997 대한응급의학회지 Vol.8 No.3

Spontaneous subarachnoid hemorrhage(SAH) is a cause of high mortality and morbidity in the emergency department. Rebleeding has been well investigated, and it is now recognized that early operation can prevent rebleeding. However, ultra-early rebleeding, which may occur prior to early operation(within 24 hours after admission), worsens the clinical outcome of patients with SAH. To determine the risk factors of ultra-early rebleeding in patients with spontaneous SAH before early operation, we analyzed the cases of 383 patients admitted within 254 hours after their last attack of SAH between 1994 to 1996. In this analysis, diagnosis of rebleeding before admission was defined only if the patients experienced a definite clinical deterioration once more after an attack suggesting SAH. After admission patients who observed a sudden neurological deterioration were subject to repeat CT scanning and rebleeding was diagnosed only when new hemorrhage was observed on the CT scan in comparison with the previous scan. 45 cases(11.7%) of 383 patients had ultra-early rebleeding. The incidence of ultra-early rebleeding significantly increased in the patients who admitted hospital within 2 hours after attack. The incidence of ultra-early rebleeding also increased in the old-age group(70 years of more), patients with high systolic blood pressure, those who underwent angiography within 6 hours of the last SAH, and patients who had poor neurological condition.

Effects of Bladder Training and/or Tolterodine in Female Patients with Overactive Bladder Syndrome: A Prospective, Randomized Study

Kyeong Ok Heo,Myung Soo Choo,Cheryn Song,Jun Tag Park,Kyu Sung Lee 대한의학회 2006 Journal of Korean medical science Vol.21 No.6

경질점성토 지반에서 Trench 굴착시 지하수위 변동에 따른 가설구조체 안정해석 기법

허창환,서성탁,김희덕,지홍기,Heo, Chang-Hwan,Seo, Sung-Tag,Kim, Hee-Duck,Jee, Hong-Kee 한국방재학회 2003 한국방재학회논문집 Vol.3 No.2

In this study, lightening material weight and normalizing structure of preventing system of landslide soil-rock in trench excavation was tried with focusing in safety construction availability and workability. In other words, risk estimate, safety management method investigation, applicability of bracing material and mechanical stability of bracing structure was studied. From these result, structural stability and structural analysis of light weight bracing structure was carried out with common structural analysis program, for examining movement mechanism of bracing structure and normalization of standard. The result are summarized as following. (1) Mechanical ability of bracing members and soil pressure parameter acting to member for ensuring mechanical propriety of bracing structural and useful of new material considering soil mechanics boundary were proposed. Also theory and method of analysis of bracing structural were proposed. (2) As a result of the structure analysis of geographical profile for light pannel used FRP as hard clay mechanical characteristics(bending moment, shear force, axial force) of panel were changed according to groundwater level and it is proved that the result of mechanical analysis is within allowable stress. Thus, light pannel is available for bracing structure in trench excavation. 본 연구에서는 트랜치 굴착시 토석붕괴 방지시설에 대한 시공상의 안전성과 시공성 그리고 작업성에 주안점을 두어 재료의 경량화 및 구조체의 표준화를 시도하였다. 즉, 위험도 사전평가와 안전관리기법을 검토하고 흙막이 부재의 적용성과 흙막이 구조의 역학적 안정성을 검토하였으며, 이들 결과로부터 흙막이 구조체의 역학적 거동매카니즘 규명과 규격의 표준화를 위하여 경량흙막이 구조체의 구조안전성과 구조해석을 실시하였으며, 그 결과를 요약하면 다음과 같다. 1) 흙막이 구조의 역학적 타당성과 토질역학적 조건을 고려한 신소재 활용성을 확보하기 위하여 흙막이 부재의 역학적 성능과 부재에 작용하는 토압정수를 제시하였으며, 흙막이 구조체의 해석이론과 방법을 제시하였다. 2) 강화합성수지(FRP)를 사용한 경량판넬 부재의 지질구조가 경질점성토인 조건을 대상으로 구조해석 결과, 지하수위 조건에 따라서 판넬의 역학적(휨모멘트, 전단력, 축응력) 특성이 변화하고 있었으며, 역학적 해석결과가 허용응력 범위에 있음을 알 수 있어 이는 경량판넬이 트랜치 굴착시에 흙막이 구조로서 유용성을 알 수 있었다.

시계열 클러스터링을 통한 호텔 유닛 단위의 에너지 소비패턴 분석

고재현(Jaehyun Go),홍탁의(Tag-Eui Hong),허연숙(Yeonsook Heo) 대한설비공학회 2019 대한설비공학회 학술발표대회논문집 Vol.2019 No.11

This study performed the time-series cluster analysis of 15-minutes FCU energy use data of three hotel rooms in Hong Kong. FCU energy use patterns were categorized into 4 patterns: “constant low consumption”, “constant high consumption”, “high consumption during the awake period”, “high consumption during the sleep period”. In addition, significant independent variables which is explaining differences of “constant low consumption” are indoor average temperature and humidity.

의식이 명료한 두통환자의 응급실내 평가와 입원 적응증

류진호,허탁,민용일 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.1

Background : Headache is a common symptom. It has not proved useful methods that the physician evaluated the alert patient who had headache. It needs the presence of predictors of intracranial pathology(ICP) which serves as influential factors in the indication evaluation and hospitalization of patients. Methods : So, in order to identify such factors, patient records were retrospectively analyzed. 168 patients with the chief complaint of headache presented to the Emergency Department of Chonnam University Hospital during the period from January 1,1995 to December 31, 1997. All were in an alert mental state and had no evidence of trauma and intoxication. Results : 14 cases(8.3%) revealed ICP. 41 cases(24.4%) revealed systemic disease. The remainder of cases were divided among unclassified headaches(61 cases, 36.3%), tension headaches(30 cases, 17.9%), and migraine(22 cases, 13.1%). Comparison of ICP-positive and ICP-negative cases revealed that IGP-positive patients could be categorized by the following findings: (1) presence of focal sign through neurological examination, (2) age greater than 55 years, (3) presence of associated symptoms, (4) acute headache. These four manifestations were proven to be statistically significant as predictors of ICP. Conclusion : Although the positive predictive value of the above criteria is not perfect for the prediction of ICP, they are worthy of clinical consideration in alert patients presenting with headache.

복부 둔사에 의한 장 천공 의심시 진단적 복강세척술의 새로운 양성기준의 의의

민용일,허탁,소정일 대한응급의학회 2000 대한응급의학회지 Vol.11 No.1

Background. Although diagnostic peritoneal lavage (DPL) is a well-established, reliably objective method of diagnosis of intraperitoneal injury, it is too sensitive to be used as a absolute indicator for emergency laparotomy. Recently, Otomo et al, have devised a new DPL criteria specifically designed and modified the classic criteria to aid in the diagnosis of intestinal injury. So the author studied the difference of diagnostic sensitivity, specificity, and accuracy between the new and classic criteria for intestinal injury. Methods. The author reviewed retrospectively one hundred fifteen patients underwent DPL from January 1993 to August 1999. The author adopted the classic criteria positive for intestinal injury when the lavage fluid was white blood cell(WBC) ≥ 500/㎣ and newly developed supplementary criteria positive when RBC ≥ 100,000/㎣, the positive-negative borderline was adjusted to WBC ≥ RBC/150, and when RBC < 100,000/㎣, to WBC ≥500/㎣. And analyzed the diference of sensitivity, specificity, and accuracy each other. Results. Among 115 patients, the sensitivity, specificity, and accuracy for intestinal injury were 96.4%, 87.4%, and 89.6% for the new criteria, and 100%, 42.5%, and 56.5% for the classic criteria. After exclusion of 10 patients in whom DPL was performed within 3 hours or after 18 hours from the time of injury, the sensitivity, specificity, and accuracy for intestinal injury were 96.4%, 97.4%, and 97.1% for the new criteria, and 100%, 46.8%, and 61% for the classic criteria. When analyzed the time interval from injury to DPL in the new criteria, 105 patients that DPL was performed between 3 to 18 hours had 2 false-positive, while 115 patiens regardless of DPL time 11 false-positive. Conclusions. The author concluded that the new criteria of DPL effluent performed between 3 to 18 hours from abdominal blunt trauma would be more specific and accurate indicator of intestinal perforation than the classic criteria. And this new criteria will be used as a reliable indicator for emergency laparotomy for that patients

특고압 전력선 열화 특성 분석

오용철(Yong-Cheul Oh),김탁용(Tag-Yong Kim),김충혁(Chung-Hyeok Kim),허민(Min Heo),정한석(Han-Seok Cheong),신철기(Cheol-Gi Shin),김진사(Jin-Sa Kim) 대한전기학회 2014 대한전기학회 학술대회 논문집 Vol.2014 No.7

휴통과 ST분절상승을 보이는 환자에서 급성심근경색증과 비심근경색증의 심전도 분석

류진호,김용권,소정일,허탁,민용일 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: ST segment elevation in patient with chest pain was seen in acute myocardial infarction and in numerous other non-infarction syndromes. The causes of non-infarction syndrome were left ventricular hypertrophy, BER(benign early repolarization), and left bundle branch block in cardiac origin and were hyperkalemia and hyperventilation syndrome in metabolic origin and were others. Furthermore, the differentiation of electrocardiogram between acute myocardial infarction and non-infarction syndrome was very difficult. So, we compared and analysed characteristics of ST segment elevation of acute myocardial infarction and non-infarction syndrome that suggested the clue of early diagnosis of coronary artery disease. Method and Materials: We retrospectively reviewed the electrocardiogram of 961 patients with chest pain who visited the emergency center from January 1999 to December 1999. Acute myocardial infarction was diagnosed by clinical finding, electrocardiogram, cardiac enzyme, echocardiogram, and myocardial spect. Left ventricular hypertrophy, BER, and left bundle branch block in cardiac origin of non-infarction syndrome were diagnosed by electrocardiographic criteria suggested by William J. Brady. Acute myocarditis, acute pericarditis, and hyperventilation syndrome were diagnosed by clinical finding. Results: Among 961 patients with chest pain, 236(24.6%) patients manifested ST segment elevation who were diagnosed acute myocardial infarction in 162(68.6%) patients and non-infarction syndrome in 74(31.4%) patients. The causes of non-infarction syndrome in 74 patients were left ventricular hypertrophy(32:13.6%), BER(28:11.9%), left bundle branch block(11:4.7%), and others(3:1.3%). Three others were acute myocarditis, acute pericarditis, and hyperventilation syndrome. Electrocardiographic characteristics of ST segment elevation of non-infarction syndrome manifested almost same finding compared to William J. Brady' criteria. Conclusion: ST segment elevation in patient with chest pain visited emergency department was seen in acute myocarction(68.6%) and the other non-infarction syndromes(31.4%). Significant number of patients were not associated with acute myocardial infarction. Therefore, we must completely understand characteristics of ST segment elevation in acute myocardial infarction and the other non-infarction syndreomes to diagnose fatal early coronary artery disease and to avoid unnecessary thrombolytic therapy.