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The Quantitative Analysis of Listening Examination in Traditional Chinese Medicine
Chiu,Chuang-Chien,Chang,Hen-Hong,Yang,Chung-Hsien INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 1999 JOURNAL OF ORIENTAL MEDICINE Vol.4 No.1
The goal of this work is to propose novel acoustic parameters of voice for the purpose of providing a quantitative analysis of auscultation in traditional Chinese medical diagnosis. There was rare amount of literatures being found related to this topic. Four novel voice parameters, which are the average number of zero-crossings, the variations on local peaks and valleys, the variations on first and second formant frequencies, and the spectral energy ratio, have been presented to analyze and identify the characteristics among the nonvacuity, qi-vacuity, and yin-vacuity subjects. Among these voice parameters, two temporal parameters, i.e., the average number of zero-crossings and the variations on local peaks and valleys, outperformed other parameters in classifying the deficient(either qi-vacuity of yin-vacuity) and non-vacuity subjects. On the other hand, the spectral energy ratio is good for the classification between qi-vacuity and yin-vacuity patients. This research is an early step in an ongoing effort to modernize the auscultation in traditional Chinese medical diagnosis.
Moscatilin Induces Apoptosis and Mitotic Catastrophe in Human Esophageal Cancer Cells
Chien-An Chen,Chien-Chih Chen,Chien-Chang Shen,Hen-Hong Chang,Yu-Jen Chen 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.10
Moscatilin, a bibenzyl derivative from the orchid Dendrobium loddigesii, has been shown to possess anticancer activity. We examined the effect of moscatilin on human esophageal cancer cells, including squamous cell carcinoma (SCC) and adenocarcinoma (ADC) cells and its possible mechanisms. Moscatilin suppressed the growth of both the histological cell lines in a dose- and time-dependent manner. Morphological changes indicative of apoptosis and mitotic catastrophe were observed following moscatilin treatment. The population of cells in the sub-G1 phase and polyploidy phase significantly increased after treatment. Immunofluorescence revealed multipolar mitosis and subsequent multinucleation in moscatilin-treated cells, indicating the development of mitotic catastrophe. Western blot showed a marked increase in expressions of polo-like kinase 1 and cyclin B1 after exposure to moscatilin. In conclusion, moscatilin inhibits growth and induces apoptosis and mitotic catastrophe in human esophageal SCC- and ADC-derived cell lines, indicating that moscatilin has broad potential against esophageal cancer