Is percutaneous destruction of a solitary liver colorectal metastasis as effective as a resection?

Ugo Marchese,Heloise Seux,Jonathan Garnier,Jacques Ewald,Gilles Piana,Bernard Lelong,Cecile De Chaisemartin,Helene Meillat,Jean-Robert Delpero,Olivier Turrini 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.2

Backgrounds/Aims: Surgical resection remains the gold standard in the treatment of colorectal liver metastasis. However, when a patient presents with a deep solitary colorectal liver metastasis (S-CLM), the balance between the hepatic volume sacrificed and the S-CLM volume is sometimes clearly unappropriated. Thus, alternatives to surgery, such as operative and percutaneous radiofrequency ablation (RFA) and microwave ablation (MWA), have been developed. This study aimed to identify the prognostic factors affecting survival of patients with S-CLM who undergo curative-intent liver resection or local destruction (RFA or MWA). Methods: We retrospectively identified 211 patients with synchronous or metachronous S-CLM who underwent either surgical resection (n=182) or local destruction (RFA or MWA; n=29) according to the S-CLM size, location, and surrounding Glissonian structures. Results: Patients who underwent RFA or MWA had S-CLM of a smaller size than those who underwent resection (mean 19.7 vs. 37.3 mm, p<.01). The 1-, 3-, and 5-year overall survival (OS) rates were 97.4%, 84.9%, and 74.9%, respectively. The 1-, 3-, and 5-year disease-free survival (DFS) rates were 77.9%, 47%, and 38.9%, respectively. S-CLM located in the left liver (p=.04), S-CLM KRAS mutation (p<.01), and extra-hepatic recurrence (p<.01) were identified as independent poor risk factors for overall survival (OS); the OS and DFS were comparable in patients with surgical procedure or percutaneous MWA. Conclusions: In eligible S-CLM cases, percutaneous MWA seems to be as oncologically efficient as surgical resection and should be include in the decision-tree for treatment strategies.

Polygenic Resistance to Scab (Venturia pirina) in an Interspecific Pear Family

Kyungho Won,Heloise Bastiaanse,Yoonkyeong Kim,Janghoon Song,Samseok Kang,Hanchan Lee,Kanghee Cho,Lester Brewer,Susan E. Gardiner,David Chagne,Vincent Bus 한국원예학회 2014 한국원예학회 학술발표요지 Vol.2014 No.5

Mechanical Thrombectomy in Patients with a Large Ischemic Volume at Presentation: Systematic Review and Meta-Analysis

Basile Kerleroux,Kevin Janot,Jean François Hak,Johannes Kaesmacher,Wagih Ben Hassen,Joseph Benzakoun,Catherine Oppenheim,Denis Herbreteau,Heloise Ifergan,Nicolas Bricout,Hilde Henon,Takeshi Yoshimoto 대한뇌졸중학회 2021 Journal of stroke Vol.23 No.3

The benefits of mechanical thrombectomy (MT) for patients with acute ischemic stroke (AIS) and a large ischemic core (LIC) at presentation are uncertain. We aimed to obtain up-to-date aggregate estimates of the outcomes following MT in patients with volumetrically assessed LIC. We conducted a Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-conformed, PROSPERO-registered, systematic review and meta-analysis of studies that included patients with AIS and a baseline LIC treated with MT, reported ischemic core volume quantitatively, and included patients with a LIC defined as a core volume ≥50 mL. The search was restricted to studies published between January 2015 and June 2020. Random-effects-meta-analysis was used to assess the effect of MT on 90-day unfavorable outcome (i.e., modified Rankin Scale [mRS] 3–6), mortality, and symptomatic intracranial hemorrhage (sICH) occurrence. Sensitivity analyses were performed for imaging-modality (computed tomography-perfusion or magnetic resonance-diffusion weighted imaging) and LIC-definition (≥50 or ≥70 mL). We analyzed 10 studies (954 patients), including six (682 patients) with a control group, allowing to compare 332 patients with MT to 350 who received best-medical-management alone. Overall, after MT the rate of patients with mRS 3–6 at 90 days was 74% (99% confidence interval [CI], 67 to 84; Z-value=7.04; I2=92.3%) and the rate of 90- day mortality was 36% (99% CI, 33 to 40; Z-value=–7.07; I2=74.5). Receiving MT was associated with a significant decrease in mRS 3–6 odds ratio (OR) 0.19 (99% CI, 0.11 to 0.33; P<0.01; Z-value=–5.92; I2=62.56) and in mortality OR 0.60 (99% CI, 0.34 to 1.06; P=0.02; Z-value=–2.30; I2=58.72). Treatment group did not influence the proportion of patients experiencing sICH, OR 0.96 (99% CI, 0.2 to 1.49; P=0.54; Z-value=–0.63; I2=64.74). Neither imaging modality for core assessment, nor LIC definition influenced the aggregated outcomes. Using aggregate estimates, MT appeared to decrease the risk of unfavorable functional outcome in patients with a LIC assessed volumetrically at baseline.

The Use of Cryotherapy in the Gout Pain Control: A Systematic Review

Alana Ludemila de Freitas Tavares,Iranilda Moha Ross,Lilian Araujo Pradal,Morgana Neves,Bárbara Heloise Trombetta Jamilk,Gladson Ricardo Flor Bertolini KEMA학회 2021 근골격계과학기술학회 Vol.5 No.1

Background Gout traditional treatment consists of anti-inflammatory drugs, analgesics and other rheumatic controllers, however, the occurrence of drug interactions occurs with a certain degree of toxicity, requiring that other methods be used to relieve symptoms. An alternative treatment is cryotherapy due to its capacity for analgesia. Purpose The aim of this study was to conduct a systematic review that addressed the literature with production on gouty arthritis and its treatment with cryotherapy. Study design Systematic review Methods This review was described according to the items requested by the PRISMA system. This is a systematic review of publications from the year 2000 to the year 2019 in the following white literature databases PubMed, LILACS, SciELO, Web of Science, Science Direct, Scopus, Cochrane, PEDro and in the gray literature a Google Scholar database. The electronic databases were consulted from November 2019. Results After searching the databases, reading and selection, two studies contemplated the methodological criteria of eligibility, being of the same authorship, both with more than ten years of publication, using similar methods of application of ice. Conclusions It was found that, despite the scarcity of studies that addressed the topic, the articles found show reasonable rigor methodological and homogeneous results, demonstrating that cryotherapy helps in reducing the pain of individuals with gout, however, there is little evidence to support this hypothesis.

Partial replacement of soybean meal with different protein sources in piglet feed during the nursery phase

Jansller Luiz Genova,Paulo Levi de Oliveira Carvalho,Newton Tavares Escocard de Oliveira,Aparecida da Costa Oliveira,Franz Dias Gois,Davi Elias de Sa e Castro,Fabio Nicory Costa Souza,Heloise Trautenm 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.11

Objective: Evaluate the partial replacement of soybean meal with different protein sources in piglet feed during the nursery phase in terms of digestibility of feed, nitrogen balance, growth performance and blood parameters. Methods: Experiment I involved 24 crossbred entire male pigs with an initial body weight (BW) of 18.28±0.7 kg and used a randomized complete block design consisting of 3 treatments (fish meal, FM; soybean protein concentrate, SPC; and soybean meal, SBM) and 8 replicates, with 1 pig per experimental unit. Experiment II involved 1,843 crossbred male and female pigs with an initial BW of 6.79±0.90 kg and was based on a completely randomized design with a 2×3 factorial arrangement (2 sexes and 3 protein sources) and 13 replicates. Results: The results of Exp. I indicate effects (p<0.05) of dietary protein sources on digestible protein (FM, 17.84%; SPC, 16.72%, and SBM, 18.13%) and on total nitrogen excretion (TNE, g/kg BW0.75/d) in which pigs fed with SBM-based feed had TNE values that were 5.36% and 3.72% greater than SPC and FM, respectively. In the Exp. II, there was difference (p<0.01) between sexes in the pre-starter I and starter phases, and total period in average daily feed intake (ADFI), which were greater in females, and between the protein sources, ADFI, final weight and daily weight gain. For urea in the pre-starter II and starter phases and glucose in the pre-starter II phase, there was a difference (p<0.05) between protein sources and between sexes, in starter phase in urea concentrations (females: 57.11 mg/dL and males: 50.60 mg/dL). Conclusion: The use of SBM as only protein source influences larger TNE (g/kg BW0.75/d), reduces the growth performance of piglets and increases plasma urea concentrations in pre-starter II phase.