0.5% 소금물에 대한 역치와 위암발생의 위험도

오희철(Heechoul Ohrr),이강희(Kang-Hee Lee),이상욱(Sang-Wook Yi) 한국농촌의학 지역보건학회 2000 농촌의학·지역보건 Vol.25 No.2

SOI를 이용한 낮은 편광 손실차를 갖는 1×4 AWG에 관한 연구

임희철,박종대 明知大學校 産業技術硏究所 2000 産業技術硏究所論文集 Vol.19 No.-

In this thesis, the design scheme, simulation and fabrication of the polarization independent 1×4 AWG was studied using SOI structure. First, this thesis presents the design parameters and fabrication process of SOI ridge waveguide. The simulated profiles were well matched to the result of EIM and BPM simulation at the wavelength of 1.55μm. Second, design and simulation were performed for the polarization independent 1×4 AWG using SOI structure, and peak wavelength shift of this device was 0.02nm by BPM simulation. The response of this device is shows the polarization independent property.

Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans

Yi, Sang-Wook,Ohrr, Heechoul,Won, Jong-Uk,Song, Jae-Seok,Hong, Jae-Seok The Korean Society for Preventive Medicine 2013 Journal of Preventive Medicine and Public Health Vol.46 No.5

Objectives: The aim of this study was to examine the levels of serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and evaluate their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans. Methods: Serum levels of TCDD were analyzed in 102 Vietnam veterans. Information on age, body mass index, and smoking status were obtained from a self-reported questionnaire. The perceived exposure was assessed by a 6-item questionnaire. Two proximitybased exposures were constructed by division/brigade level and battalion/company level unit information using the Stellman exposure opportunity index model. Results: The mean and median of serum TCDD levels was 1.2 parts per trillion (ppt) and 0.9 ppt, respectively. Only 2 Vietnam veterans had elevated levels of TCDD (>10 ppt). The levels of TCDD did not tend to increase with the likelihood of exposure to Agent Orange, as estimated from either proximity-based exposure or perceived self-reported exposure. The serum TCDD levels were not significantly different according to military unit, year of first deployment, duration of deployment, military rank, age, body mass index, and smoking status. Conclusions: The average serum TCDD levels in the Korean Vietnam veterans were lower than those reported for other occupationally or environmentally exposed groups and US Vietnam veterans, and their use as an objective marker of Agent Orange exposure may have some limitations. The unit of deployment, duration of deployment, year of first deployment, military rank, perceived self-reported exposure, and proximity-based exposure to Agent Orange were not associated with TCDD levels in Korean Vietnam veterans. Age, body mass index and smoking also were not associated with TCDD levels.

Agent Orange Exposure and Prevalence of Self-reported Diseases in Korean Vietnam Veterans

Yi, Sang-Wook,Ohrr, Heechoul,Hong, Jae-Seok,Yi, Jee-Jeon The Korean Society for Preventive Medicine 2013 Journal of Preventive Medicine and Public Health Vol.46 No.5

Objectives: The aim of this study was to evaluate the association between Agent Orange exposure and self-reported diseases in Korean Vietnam veterans. Methods: A postal survey of 114 562 Vietnam veterans was conducted. The perceived exposure to Agent Orange was assessed by a 6-item questionnaire. Two proximity-based Agent Orange exposure indices were constructed using division/brigade-level and battalion/ company-level unit information. Adjusted odds ratios (ORs) for age and other confounders were calculated using a logistic regression model. Results: The prevalence of all self-reported diseases showed monotonically increasing trends as the levels of perceived self-reported exposure increased. The ORs for colon cancer (OR, 1.13), leukemia (OR, 1.56), hypertension (OR, 1.03), peripheral vasculopathy (OR, 1.07), enterocolitis (OR, 1.07), peripheral neuropathy (OR, 1.07), multiple nerve palsy (OR, 1.14), multiple sclerosis (OR, 1.24), skin diseases (OR, 1.05), psychotic diseases (OR, 1.07) and lipidemia (OR, 1.05) were significantly elevated for the high exposure group in the division/brigade-level proximity-based exposure analysis, compared to the low exposure group. The ORs for cerebral infarction (OR, 1.08), chronic bronchitis (OR, 1.05), multiple nerve palsy (OR, 1.07), multiple sclerosis (OR, 1.16), skin diseases (OR, 1.05), and lipidemia (OR, 1.05) were significantly elevated for the high exposure group in the battalion/company-level analysis. Conclusions: Korean Vietnam veterans with high exposure to Agent Orange experienced a higher prevalence of several self-reported chronic diseases compared to those with low exposure by proximity-based exposure assessment. The strong positive associations between perceived self-reported exposure and all self-reported diseases should be evaluated with discretion because the likelihood of reporting diseases was directly related to the perceived intensity of Agent Orange exposure.

Low Systolic Blood Pressure and Mortality From All Causes and Vascular Diseases Among Older Middle-aged Men: Korean Veterans Health Study

Yi, Sang-Wook,Ohrr, Heechoul The Korean Society for Preventive Medicine 2015 Journal of Preventive Medicine and Public Health Vol.48 No.2

Objectives: Recently, low systolic blood pressure (SBP) was found to be associated with an increased risk of death from vascular diseases in a rural elderly population in Korea. However, evidence on the association between low SBP and vascular diseases is scarce. The aim of this study was to prospectively examine the association between low SBP and mortality from all causes and vascular diseases in older middle-aged Korean men. Methods: From 2004 to 2010, 94 085 Korean Vietnam War veterans were followed-up for deaths. The adjusted hazard ratios (aHR) were calculated using the Cox proportional hazard model. A stratified analysis was conducted by age at enrollment. SBP was self-reported by a postal survey in 2004. Results: Among the participants aged 60 and older, the lowest SBP (<90 mmHg) category had an elevated aHR for mortality from all causes (aHR, 1.9; 95% confidence interval [CI], 1.2 to 3.1) and vascular diseases (International Classification of Disease, 10th revision, I00-I99; aHR, 3.2; 95% CI, 1.2 to 8.4) compared to those with an SBP of 100 to 119 mmHg. Those with an SBP below 80 mmHg (aHR, 4.5; 95% CI, 1.1 to 18.8) and those with an SBP of 80 to 89 mmHg (aHR, 3.1; 95% CI, 0.9 to 10.2) also had an increased risk of vascular mortality, compared to those with an SBP of 90 to 119 mmHg. This association was sustained when excluding the first two years of follow-up or preexisting vascular diseases. In men younger than 60 years, the association of low SBP was weaker than that in those aged 60 years or older. Conclusions: Our findings suggest that low SBP (<90 mmHg) may increase vascular mortality in Korean men aged 60 years or older.

화학제조업의 사례구축을 통한 디지털 생산정보관리시스템 (통합 POP 시스템) 핵심 업무 프로세스 표준화 및 효과분석

김치곤,권희철,전형도,윤경배,Kim, ChiGon,Kwon, HeeChoul,Zun, Hyungdo,Yoon, KyungBae 국제문화기술진흥원 2017 The Journal of the Convergence on Culture Technolo Vol.3 No.3

본 연구는 중소기업의 정보화를 추진함에 있어, 정보화 중에서도 중단기적인 도입 성과를 낼 수 있는 생산정보관리시스템 구축을 위하여, 화학제조업 분야의 핵심 업무 프로세스에 대하여 표준화를 연구하고 그에 따른 생산정보관리시스템을 구축 적용하는데 제공하고자 한다. 화학제조업 생산정보관리시스템 표준화를 위한 개발방법론은 중소기업기술정보진흥원에서 기 연구 개발된 생산정보관리시스템 개발 방법론(PSDM)을 적용하며, 표준화 대상은 시스템 구성도, 업무절차 흐름도, Menu Structure 등과 같이 시스템구축 시 골격이 되는 핵심 업무 프로세스이다. 본 연구로 생산정보관리시스템을 구축하고자 하는 화학제조업 중소기업 및 관련 전문 IT업체들이 표준화된 핵심 업무 프로세스를 적용하여 시스템을 보다 효과적으로 구축 할 수 있으며, 시스템에 대한 구축 용이성과 신뢰성을 제공하며 아울러 핵심 업무 프로세스의 활용이 극대화되기 위해서 사후관리 교육훈련 및 유지보수 방안도 제시하고 있다. 본 연구 결과를 적용함으로써 생산 공정의 불합리한 요소제거, 생산제품 품질 향상, 생산비용절감이 가능하다. The purpose of this study is to study the standardization of the core business process in the chemical manufacturing industry and to establish a production information management system for the purpose of establishing the production information management system that can achieve mid -To be applied. The development methodology for the standardization of the chemical manufacturing information system is applied to the production information management system development methodology (PSDM) that was developed and developed by the Agency for Technology and Information Promotion of Small and Medium Enterprises. The standardization target is the system structure, It is a core business process that becomes a skeleton during construction. In this study, the chemical manufacturing SMEs and related professional IT companies who want to build the production information management system can apply the standardized core business process more effectively to build the system more effectively, and provide ease of installation and reliability to the system, In order to maximize the utilization of processes, follow-up education training and maintenance measures are suggested. Applying the results of this study, it is possible to eliminate the unreasonable elements of the production process, improve the quality of production product, and reduce production cost.

Reproductive risk factors for cardiovascular disease mortality among postmenopausal women in Korea: the Kangwha Cohort Study, 1985-2005

Chang, Hoo Sun,Odongua, Nemekhee,Ohrr, Heechoul,Sull, Jae Woong,Nam, Chung Mo The North American Menopause Society 2011 Menopause Vol.18 No.11

OBJECTIVE:: The relationship between reproductive factors and the risk of mortality from cardiovascular disease in postmenopausal women is unclear. In this study, we aimed to investigate this relationship in Korean postmenopausal women. METHODS:: Subcohort analysis was carried out using the data of 3,257 postmenopausal women (age, ≥55 y at study entry) from the Kangwha Cohort Study who were followed up from 1985 until 2005. Cox proportional hazards models were used to evaluate the associations between reproductive factors and cardiovascular disease mortality. RESULTS:: The risk of cardiovascular mortality in women who were 20 to 22 years old at first childbirth was 26% lower (95% CI, 0.60-0.92) than that in women younger than 20 years at first childbirth, after adjustment for age at entry, body mass index, hypertension, drinking, smoking, education, and occupation. Early first childbirth was associated with increased cardiovascular disease mortality (P trend = 0.036). The risk of coronary heart disease mortality was 51% lower in women who were 17 to 18 years old at menarche (95% CI, 0.25-0.95) than that in women who were younger than 17 years at menarche. CONCLUSIONS:: An inverse relationship between age at first childbirth and the risk of cardiovascular disease mortality exists. In addition, early menarche may be a reproductive risk factor for coronary heart disease mortality.

Low Systolic Blood Pressure and Vascular Mortality Among More Than 1 Million Korean Adults

Yi, Sang-Wook,Mok, Yejin,Ohrr, Heechoul,Yi, Jee-Jeon,Yun, Young Duk,Park, Jihwan,Jee, Sun Ha American Heart Association 2016 Circulation Vol.133 No.24

<P>Background-The association between low systolic blood pressure (SBP) and vascular disease is unclear, especially in nonclinical populations. Methods and Results-We studied 1 235 246 individuals who participated in routine medical examinations between 1992 and 1995. The hazard ratios (HRs) were adjusted for potential confounders. During 22.7 million person-years of follow-up, 34 816 individuals died of atherosclerotic vascular diseases. An increase in SBP was directly related to an increase in vascular mortality at SBP above approximate to 100 mmHg. The group with the lowest SBP (<90 mm Hg) had a higher HR for mortality from atherosclerotic vascular disease (HR, 1.53; 95% confidence interval, 1.15-2.03) in comparison with those with an SBP of 90 to 99 mm Hg. The HR associated with the lowest SBP was 2.54 (95% confidence interval, 1.51-4.29) for ischemic heart disease and 1.21 (95% confidence interval, 0.79-1.85) for stroke. Regarding stroke subtype, mortality from hemorrhagic stroke (HR per 10 mm Hg increase, 0.53; 95% confidence interval, 0.29-0.96), rather than mortality from ischemic stroke (HR per 10 mm Hg increase, 1.00; 95% confidence interval, 0.51-1.97), was inversely associated with SBP when SBP fell to <100 mm Hg. Even when excluding the first 5 years of follow-up, the HRs associated with the lowest SBP did not decrease. The inverse association between SBP and vascular mortality in the range <100 mm Hg tended to be apparent in people aged 60 to 95 years in comparison with individuals aged 30 to 59 years. Conclusions-J-curve associations exist between SBP and vascular mortality, which reach a nadir at approximate to 100 mm Hg. SBP of <90 mm Hg may portend death from vascular disease, particularly from ischemic heart disease.</P>

A small-scale survey on the status of intestinal parasite infections in rural villages in Nepal

Tai-Soon YONG,Seobo SIM,Jongweon LEE,Heechoul OHRR,Myung-Ho KIM,Hyunsoo KIM 대한기생충학열대의학회 2000 The Korean Journal of Parasitology Vol.38 No.4

표준화된 PSDM을 사용한 최적의 WBS 및 효과적인 중소기업 정보화 시스템 구축에 관한 연구

윤경배,권희철,Yoon, KyungBae,Kwon, HeeChoul 한국인터넷방송통신학회 2014 한국인터넷방송통신학회 논문지 Vol.14 No.6

효과적인 중소기업 정보화를 위하여 표준화된 생산정보화 시스템 개발 방법론(PSDM)을 통하여 단계별 주요 업무에 대한 작업을 정의하고 관련 연관도를 통하여 업무에 대한 선행 및 후행 관계를 정의한 후 그에 따른 프로젝트 범위 일정 비용 인적자원 관리를 위한 최적의 업무분류체계(WBS : Work Breakdown Structure)를 연구개발 하고자한다. 시스템의 신뢰성 품질 생산성 향상을 위한 관리 항목 설정, 중소기업 IT업체 감리업체 등 참여 기업간의 의사소통, 그리고 구축된 생산정보화의 유지보수를 포함한 운영지원 등 보다 체계적이고 효율적인 시스템 구축을 위해 중소기업 생산정보화에 적합한 WBS의 연구로 생산정보화를 구축하고자 참여하는 많은 중소기업 및 IT업체들이 표준화된 방법론을 이용하여 시스템 구축을 보다 효과적으로 수행할 수 있으며, 보다 높은 신뢰성을 가진 시스템을 계획된 개발 일정에 알맞게 구축한다. We would like to study and develop the optimized WBS(Work Breakdown Structure) considering project's range, schedule, cost and human resources management with defining phased work in main task and preceding and escorting relationships for effective small and medium enterprises' informatization through standardized PSDM(Production System Development Methodology). For more systemic and effective system built-up, it introduces production information with WBS study which is appropriate for the small and medium enterprises with setting up management items for enhancing system's reliability, quality, productivity, smooth communication among the participated enterprises such as the small and medium enterprises, IT enterprises, and supervision enterprises, and operational support including maintenance of the built system. This study is purpose of helping a lot of the small and medium enterprises and IT enterprises to build up the systems more effective and reliable within planned schedule using the standardized methodology.