Efficacy of Hyperbaric Oxygen Therapy on Central Corneal Thickness, Intraocular Pressure, and Nerve Fiber Layer in Patients with Type 2 Diabetes: A Prospective Cohort Study

Havva Kaldırım,Ku, rsat Atalay,Banu Ceylan,Serpil Yazgan 대한안과학회 2021 Korean Journal of Ophthalmology Vol.35 No.1

Purpose: To evaluate the effect of hyperbaric oxygen therapy (HBOT) on central corneal thickness (CCT), intraocular pressure(IOP), and the retinal nerve fiber layer (RNFL) thickness in patients with type 2 diabetes mellitus. Methods: This prospective non-randomized cohort study consisted of type 2 diabetes mellitus patients who received 30sessions of HBOT for diabetic foot ulcer. The CCT, IOP, and RNFL measured at baseline, after the 10th session of HBOT, afterthe 20th session of HBOT, after the 30th session of HBOT, and after the 3 months of the last session of HBOT. We gained thesuperior-nasal, superior-temporal, inferior-nasal, inferior-temporal, nasal and temporal quadrant RNFL values with a spectral-domain optical coharence tomography. Results: Forty-six eyes of 46 patients included in the study. During the study period, a statistically significant increase in meanIOP values compared to baseline was observed (p < 0.001). We found no significant changes at CCT and all quadrants of RNFLvalues during HBOT and after 3 months of the treatment (p > 0.05). During the study period, the IOP levels increased over21 mmHg (between 22 and 28 mmHg) in seven eyes (15.2%). The mean hemoglobin A1c values of these patients with IOP>21 mmHg were 8.2 ± 0.9 mg/dL, and there was significant differences compared with those of patients with IOP values ≤21mmHg (7.4 ± 2.8 mg/dL) (p = 0.001). Conclusions: HBOT increase IOP in type 2 diabetic patients especially in ones with impaired blood glucose regulation. However,it does not cause any changes in CCT and RNFL. As diabetic retinopathy and diabetic foot ulcer are in common pathologies,thus this brief report concludes a need for further studies with longer follow-up periods to explore the potential interactionof HBOT on CCT, IOP, and RNFL.

Traditional topical herbal therapies in psoriasis

Havva Ozge Keseroglu,Müzeyyen Gönül 셀메드 세포교정의약학회 2014 TANG Vol.4 No.4

Psoriasis is a common, chronic, recurrent, immune-mediated inflammatory disorder of skin. Although conventional topical and systemic therapies yield remission for a while, they carry a risk of many side effects that limit the long term use of these agents and the disease recurs generally in a short period of time after cessation of therapy. An increasing number of psoriatic patients are using herbal products as a treatment to control their disease with less side effects. Clinicians should be aware of plants used in psoriasis and side effects related with them. The aim of this article is to review the different herbs used in psoriasis treatment.

Comparison of Femoral Geometry among Cases with and without Hip Fractures

Havva Talay Calis,Merih Eryavuz,Mustafa Calis 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.5

Hip fractures have high morbidity and mortality rate for the people as a complication of osteoporosis and is generally seen in old age. It is known that femoral geometric measurements are important in the assessment of hip fracture risks. This study aimed to examine the association between hip geometry and hip fracture in post-menopausal elderly females. In the present study, 232 hip X-rays were taken from women with no hip fractures (Group 1) and 29 post-menopausal women with hip fractures (Group 2) after a minor trauma. After standard anterior-posterior plain pelvic X-ray radiographs were obtained, various radiographic measurements were performed in all cases, including the hip axis length (HAL), femoral neck axis length (FAL), acetabular width (AW), femoral head width (HW), femoral neck width (FW), femoral shaft width (FSW), intertrochanteric width (TW), lateral and medial cortical thickness of the femoral shaft (LCT, SMCT), femoral neck cortical thickness (NMCT) and femoral neck-shaft angle (Q-angle). In group 1, the mean age, weight and height were 62.5±7.4 years, 70.8±12.5kg, and 157.5±6.7cm, respectively. In group 2, these values were 70.17±6.8 years, 64.7±11.5 kg, and 158.3±2.7cm, respectively. There were no statistically significant differences in the measurements of HAL, FAL, AW and HW between the two groups. In group 2, the mean FW value was significantly higher than in group 1 (p= 0.01). The mean values for FSW, TW, NMCT, SMCT, LCT were statistically lower in group 2 than those in group 1 (p= 0.01, p=0.038, p=0.001, p<0.001, p<0.001, respectively). Q-angle was also significantly higher in cases with hip fracture than in cases with no hip fracture (p=0.01). The values of FW, FSW, TW, NMCT, SMCT, LCT and Q-angle seem to be important parameters in the evaluation of hip fracture risks. However, further studies are needed to clarify this conclusion.

Comparison of Anatomical and Functional Outcomes of Intravitreal Dexamethasone Implant between Phakic and Pseudophakic Eyes with Diabetic Macular Edema

Havva Kaldırım,Fatma Savur,Ahmet Kırgız,Kursat Atalay 대한안과학회 2020 Korean Journal of Ophthalmology Vol.34 No.5

Purpose: To compare the effectiveness of dexamethasone (DEX) intravitreal implants for the treatment of diabetic macularedema between phakic and pseudophakic eyes after a follow-up. Methods: A total of 79 eyes in 79 patients with diabetic macular edema who were insufficiently responsive to the previousanti-vascular endothelial growth factor treatment and applied intravitreal DEX implant were included in this retrospectivestudy. The patients were divided into two groups according to their type of lenses: pseudophakic (group 1) and phakic (group 2). Best-corrected visual acuity, intraocular pressure (IOP), retinal nerve fiber layer thickness, and central macular thicknesschanges in the two groups were compared. Results: Group 1 comprised 42 eyes in 42 patients with a mean age of 64.02 ± 3.79 years, while group 2 comprised 37 eyes in37 patients with a mean age of 64.19 ± 5.08 years. In both groups, best-corrected visual acuity improved significantly with asignificant decrease in central macular thickness (p < 0.001). In both lens types, the IOP values decreased significantly on thefirst day but subsequently increased significantly compared to baseline from one week to six months. Increases in IOP valueswere significantly higher in group 1 at the first week, 1st month, and 6th month compared with group 2. During follow-up,the inferior quadrant retinal nerve fiber layer showed a significant decrease in both groups. Conclusions: In both phakic and pseudophakic eyes, intravitreal DEX implantation is an effective treatment method withlow-risk complications. In our study, the pseudophakic group experienced a significantly earlier increase in IOP and at higherlevels than did the phakic group. In light of these data, we suggest that in patients with pseudophakic eyes, follow-ups for IOPshould be stricter and started earlier after intravitreal DEX treatment.

Effect of homogenization heat treatment on the mechanical properties of AlMgSi alloys with different Cr content

Havva Demirpolat,Seraceddin Akdı,Bülent Alkan 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.12

AlMgSi alloys with two Cr compositions (0.17 wt% and 0.08 wt%) were subjected to different homogenization heat treatment soak conditions at: 560 °C, 580 °C, 600 °C with soak time duration of 6 h, 8 h, and 10 h; subsequently, alloys were cooled by air. Metallographic examination methods were used to determine microstructure after homogenization heat treatment. Hardness measurements were used to assess the mechanical properties. The results indicated that high Cr concentration in Al alloy contributed entirely transformation of β-AlFeSi into cubic α-AlFeSi phase with 580 °C - 600 °C soak temperature condition. At the same time, high levels of Cr addition led to the formation of higher volume fractions in the alloy. The Mg 2 Si particles entirely dissolved in the Al matrix and homogeneously dispersed under this annealing condition. The specimens reached maximum hardness after homogenization heat treatment at 580 °C for 8 h. The hardness values of the sample with 0.17 wt% Cr are higher than the sample with 0.08 wt% Cr for relatively long-term soak time at 8 h-10 h and high soak temperature at 580 °C - 600 °C.

Effect of Topical Antibiotic Prophylaxis on Conjunctival Flora and Antibiotic Resistance Following Intravitreal Injections in Patients with Type 2 Diabetes

Havva Kaldirim,Serpil Yazgan,Ahmet Kirgiz,Bilge Ozdemir,Ahu Yilmaz 대한안과학회 2020 Korean Journal of Ophthalmology Vol.34 No.4

Purpose: We sought to determine changes in the conjunctival bacterial flora and antibiotic resistance after topical antibioticdrops for infection prophylaxis were administered following intravitreal injections in patients with type 2 diabetes. Methods: This prospective and nonrandomized cohort study included 116 eyes of 116 treatment-naive patients with type2 diabetes who received six serial intravitreal anti-vascular endothelial growth factor injections for macular edema. Threeconjunctival cultures were obtained from each eye over the course of the study (Culture 1, baseline; Culture 2, 1 month afterthe third injection; and Culture 3, 1 month after the sixth injection). The study subjects were given topical moxifloxacinhydrochloride for 4 days after each monthly intravitreal injection. The growth patterns of conjunctival bacterial flora and theantibiotic resistance to several commonly used antibiotics were examined. Results: The rate of culture positivity increased significantly during the observation period (Culture 1, n = 47, 40.5%; Culture2, n = 58, 50%; Culture 3, n = 76, 65.5%, p < 0.001). The bacterium with the highest baseline culture positivity was Staphylococcusepidermidis (n = 45, 38.8%), which increased significantly during the observation period (p < 0.001). No significant increasewas noted in the culture positivity of the other bacteria with baseline culture positivity (p > 0.05). Regarding antibioticsusceptibility, significant increases in resistance to the fluoroquinolone group of drugs were noted (p < 0.001). No significantchanges in sensitivity were detected in the other 11 investigated antibiotics that are commonly used in clinical practice (p >0.05). Conclusions: The use of topical moxifloxacin after each intravitreal injection significantly increases the fluoroquinolone resistanceof the ocular surface flora and the culture-positivity rate of S. epidermidis in patients with type 2 diabetes.

Prevalence of herbal therapy usage in patients with psoriasis in Turkey

Keseroglu, Havva Ozge,Gonul, Muzeyyen,Kurmus, Gokce Isil Cellmed Orthocellular Medicine and Pharmaceutical 2015 셀메드 (CellMed) Vol.5 No.2

Many patients with psoriasis look for treatment options other than conventional treatment to control their disease with less side effects. We evaluated the prevalence and characteristics of herbal therapy usage among patients with psoriasis in Turkey. A self-prepared questionnaire about herbal therapies was applied to the psoriatic patients attended our dermatology clinic between October 2013 and December 2013. A total of 100 patients (55 male, 45 female; 7 - 80 years of age) were included in this study. Fortynine percent of patients used at least one form of herbal therapies. Juniperus oxycedrus and Aloe vera were found to be the most frequently used plants. 36.7% of the patients get benefit from herbal therapy. Only 12.2% of patients had informed their clinicians during or after herbal therapy usage. 22.4% of the patient had continued conventional treatment during herbal therapies. Side effects related with herbal therapy were developed in 26.5% of the patients. The risk of side effects was found to be 5.23 times more in patients using phytotherapies systemically compared with ones using topically. Our results show that herbal therapy usage is common among patients with psoriasis in Turkey. Since herbal therapies have the potential of interacting with the medical treatment modalities and causing life threatening allergic reactions, clinicians should be aware of plants used in psoriasis and possible adverse reactions related with them and also should not forget asking about herbal therapy history.

Atypical β-Catenin Activated Child Hepatocellular Tumor

Aynur Turan,Havva Akmaz Unlu,Esra Karakus,Arzu Yazal Erdem,Zeynep Ilerisoy Yakut 대한소아소화기영양학회 2015 Pediatric gastroenterology, hepatology & nutrition Vol.18 No.2

Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The β-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular ad-enomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of β-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-1α-inactivated hepatocellular adenomas subtype, has not been pre-viously reported in any β-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.

Atypical β-Catenin Activated Child Hepatocellular Tumor

Turan, Aynur,Unlu, Havva Akmaz,Karakus, Esra,Erdem, Arzu Yazal,Yakut, Zeynep Ilerisoy The Korean Society of Pediatric Gastroenterology 2015 Pediatric gastroenterology, hepatology & nutrition Vol.18 No.2

Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The ${\beta}$-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular adenomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of ${\beta}$-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-$1{\alpha}$-inactivated hepatocellular adenomas subtype, has not been previously reported in any ${\beta}$-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.

A preliminary phylogenetic analysis of ribbed-pine-borer (Rhagium inquisitor) based on mitochondrial COI sequences

Yunus Emre Çakmak,Havva Kübra Soydabaş-Ayoub,Fevzi Uçkan 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.3

The increased volume of intercontinental-trade had facilitated the distribution of species, including invaders. Wooden packaging materials, goods and timber are being transported via international ports in East of the Marmara Basin, where has vast forests. That forests provide an appropriate-mediator for the introduction and invasion of wood-boring insects, which are the most common group being transported between continents. One of them is Rhagium inquisitor, which has a pivotal role in wood decay, nevertheless, it is detrimental for industrial wood. We analyzed the 654 bp length of cytochrome c oxidase I (COI) gene, to determine native and introduced haplotypes of the ribbed-pine-borer, to investigate their phylogenetic relationships and possibly cryptic speciation of the morphospecies. It was found out that sixteen haplotypes were divided into five haplogroups. The groups were assembled on two main lineages: Eurasian and American. The genetic distance between the American (Groups 1–3), Asian (Group-4) and European (Group-5) clusters ranged from 3 to 10%; between haplotypes ranged from 0.2 to 10.9%. The distances between the specimens of the Marmara Basin (H9-12, Group-4) were lower compared to H16, which nested in Group-5. That haplotype was sampled on imported timber and was found out that it is shared between France, Germany, Italy, and Austria. Maximum Likelihood, Neighbor-Joining and Bayesian Inference trees showed the same topologies, and Median-Joining network also supported them. Contrary to the usual, our findings point out that some species might have been introduced from Europe to Asia. Furthermore, the high genetic diversity of the bark-runner between continents could be a sign of crypticallopatric speciation.