Synthesis and Biological Evaluation of Novel Imidazolone Derivatives as Potential COX-2 Inhibitors

Hassanein, Hassanein H.,Maha, M. Khalifa,El-Samaloty, Ola N.,El-Rahim, Mohamed Abd,Taha, Ragia A,Magda, M.F. Ismail 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5

Three novel series of 2-(substituted phenyl)-4-(substituted arylidene)-imidazolone-5-(4H)-ones were derived from the corresponding oxazolones by condensation with different arylamines. Eleven of the synthesized compounds were selected and evaluated for their effect on carrageenan-induced rat paw edema. Compound 4b had the same efficacy as the reference standard (indomethacin), and compounds 3b, 3c, 4a, 4d and 9a showed good to excellent activities, with other compounds only weakly active. The potent compounds were evaluated for their inhibitory activities against COX-2-catalyzed $PGE_2$ production, with 4a, 4b and 3c showing strong inhibitory activity.

Preparation and Characterization of Thin Films Bismuth(III) Oxide/Zinc Oxide Nanostructures Prepared by Thermal Evaporation Technique as Gas Sensor Applications

Hassanein S. Suhail,Ali R. Abdulridha 한국전기전자재료학회 2024 Transactions on Electrical and Electronic Material Vol.25 No.1

In This work, they made Bismuth oxide (Bi2O3-based) and zinc oxide (ZnO)–doped thin films using thermal evaporation. XRD confirms the phase geometries of monoclinic and (Bi2O3/ZnO) thin films. When ZnO is added, the average crystal size decreases from 17.35 to 8.67 nm. Structures have been examined using Fourier transform infrared (FT-IR) and scanning electron microscopy. The Fourier transform infrared (FT-IR) investigation found no chemical reactions in the (Bi2O3/ZnO) thin films. A scanning electron microscopy (SEM) examination of the (Bi2O3/ZnO) thin films showed uniform results. Increased ZnO doping reduces the diameter by 67.6%, from 34.20 to 11.06 nm. The optical properties of the (Bi2O3/ZnO) thin film material are examined in this work. It has been shown that (Bi2O3/ZnO) concentration increases absorbance and absorption coefficients. The transmittance and energy band gaps decreased as ZnO concentrations with significant UV light absorption increased. The direct current (D.C) electrical conductivity of (Bi2O3/ZnO) thin films is positively correlated with (ZnO) nanoparticle concentration and temperature, according to experiments. At the same time, the activation energy falls with (ZnO) nanoparticle concentration, given a fixed quantity. The gas sensor showed 96.4% sensitivity to H2S gas at 200°C. The experiment employed 50 ppm H 2 S. Finally, the (Bi2O3/ZnO) thin film examination reveals their structural characteristics and conductivity. These results may be helpful in UV sensors and gas sensors. The utilisation of (Bi2O3/ZnO) thin film gas sensor has demonstrated significant potential as a viable option for gas sensing systems, primarily attributed to the enhanced surface area achieved by the application of metal oxide catalysts. The present study also discusses the mechanisms implicated in the augmentation of gas response and the broadened range of applications.

Interaction Between time of Nodal Explant Collection and Growth Regulators Determines the Efficiency of Morus alba Micropropagation

Hassanein A.M.,Galal A.A.,Azooz M.M. The Korean Society of Plant Biotechnology 2003 Plant molecular biology and biotechnology research Vol.5 No.4

The hormonal requirement suiting micropropagation of Morus alba during any season throughout the year was studied. Sprouting frequency from axillary buds of M. alba was greatly influenced by the time of explant collection, the highest value was achieved when nodal explants were collected at the end of bud dormancy period (late in March) and cultured on Murashige and Skoog (MS) medium supplemented with low concentration (0.5 mg/L) of BAP, kinetin or IBA (85-68%). In addition, they showed higher axillary bud sprouting on growth-regulators-free medium (49%) than others collected in autumn or winter and cultured on medium supplemented with various growth regulators (47-48%). Regardless of that period, young explants with greenish buds collected in summer exhibiting high sprouting frequency (66%) on MS medium supplemented with 0.5 mg/L kinetin and 0.5 mg/L GA3. Shoot multiplication via adventitious bud formation was achieved when the nodal explants were cultured on MS medium supplemented with 2 mg/L BAP and 0.2 mg/L IBA. Further multiplication via nodal explants of in vitro grown shoots was obtained on MS medium supplemented with 0.5 mglL BAP and 0.5 mg/L GA3. While half strength MS medium supplemented with low concentration (0.5 mg/L) of IBA, IAA or 2,4-D stimulated adventitious root formation, IBA was the best. After transfer the plantlets to the soil, acclimatization for three weeks was essential prerequisite for survival in high frequency (92%). Peroxidase activity is related to break of bud dormancy where maximum enzyme activity was detected when the lateral buds were induced to commence growth under field condition (early in spring) or in vitro.

Model-based adaptive control system for autonomous underwater vehicles

Hassanein, Osama,Anavatti, Sreenatha G.,Shim, Hyungbo,Ray, Tapabrata Elsevier 2016 Ocean engineering Vol.127 No.-

<P><B>Abstract</B></P> <P>The paper deals with the development of indirect adaptive controllers based on Hybrid Neuro-Fuzzy Network (HNFN) approach for Autonomous Underwater Vehicles (AUVs). The non-linear, coupled and time-varying dynamics of AUVs necessitates the development of adaptive controllers. The on-line identification and adaptation of the controller is carried out using the HNFN approach. The methodology uses the input-output data to come up with a structure for the controller and optimal adaptation of the parameters to achieve the required accuracy. The Semi-Serial-Parallel-Model is employed both for identification and control. Initial validation of the identification results are carried out numerically using a mathematical model. Hardware-in-loop (HIL) simulations are presented to validate the controller before carrying out the experiments. Experimental results show that the proposed controller is capable of suitably controlling the AUV in real environment and demonstrate its robust characteristics.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The paper deals with the development of intelligent controllers. </LI> <LI> Non-linear dynamic systems is used as the example to illustrate the system. </LI> <LI> Experimental results are provided to validate the algorithms. </LI> </UL> </P>

Hormonal Requirements Induced Different Regeneration Pathways in Alhagi graecorum

Hassanein, A.M. The Korean Society of Plant Biotechnology 2004 Plant molecular biology and biotechnology research Vol.6 No.3

Hormonal requirements inducing different regeneration pathways with particular emphasis on somatic embryo-genesis in Alhagi graecorum were studied. While combination of 0.5 $\mu{M}$ 2,4-dichlorophenoxyacetic acid (2,4-D), 2.5 $\mu{M}$ 6-benzylaminopurine (BAP) and 5 $\mu{M}$ 1-naphthaleneacetic acid (NAA) in MS medium induced callus formation and callus maintenance from internodal explants, each alone or in combination with other induced distinct regeneration pathway. Adventitious bud formation was induced on MS medium supplemented with 2.5 $\mu{M}$ BAP. It was improved when 2.5 $\mu{M}$ BAP was used in combination with 5 $\mu{M}$ NAA. MS medium containing 0.5 $\mu{M}$ 2,4-D or 5 $\mu{M}$ NAA induced the formation of abnormal direct somatic embryos. While increase of 2,4-D concentration (1.125-9) resulted in the formation of viable embryogenic mass, increase of NAA did not change its effect. NAA should be used in combination with 2,4-D even at low concentration (0.5 $\mu{M}$) to form embryogenic mass. In A. gaecorum, the role of 2,4-D as trigger of somatic embryogenesis and BAP as trigger of adventitious bud formation was deduced, but for maximum yield certain auxin-cytokinin ratio should be applied. Embryogenic masses characterized by high water content, low peroxidase activity, and low number of peroxidase and glutamate oxaloacetate transaminase bands in comparison with calli obtained under conditions stimulating adventitious bud formation. The resulted differential gene expression, which could be detected by native-PAGE patterns, could be used as marker for organogenic pathway in A. graecorum.

Investigation of the Morphological, Optical, and D.C Electrical Characteristics of Synthesized (Bi2O3/ZnO) Nanocomposites, as Well as Their Potential Use in Hydrogen Sulfide Gas Sensor

Hassanein S. Suhail,Ali R. Abdulridha 한국전기전자재료학회 2023 Transactions on Electrical and Electronic Material Vol.24 No.3

In this present work, bismuth oxide (based on Bi2O3) and zinc oxide (ZnO-doped) thin films were produced by thermal evaporation (RT) method on 50-nm-thick glass substrates and annealed at 573 K. SEM showed that the (Bi2O3/ZnO) nanoparticles were evenly dispersed throughout when the ZnO doping concentration was increased. The actual result of the optical characteristics of (Bi2O3/ZnO) showed that (extinction coefficient, refractive index, real part and imaginary part of the dielectric constant) increase with increasing concentrations of ZnO nanoparticles. This behavior makes them excellent optical materials for photonics applications. The results of the D.C electrical characteristics show that the D.C electrical conductivity of the (Bi2O3/ZnO) nanocomposites increases with increasing nanoparticle (ZnO) concentrations and temperature. At the same time, the resistance and activation energy decrease with increasing nanoparticle (ZnO) concentrations. The measured gas sensor revealed a sensitivity to H2S of about 69.74% at 200 °C, decreasing to about 55.14% at 250 °C and 51.42% at 300 °C. Finally, the results of the structural and conductive characteristics of (Bi2O3/ZnO) thin films can be used in various nanoelectronics devices and gas sensors. Finally, the results expected that metal oxide nanostructures will prove to be the most effective building blocks for developing cutting-edge gas sensors. The effects of various doping’s on the morphology and crystal structure of ZnO materials are examined in depth in this article. This article provides sound advice for developing high-performance semiconductor oxide sensing materials based on zinc oxide (ZnO).

Micro-propagation Factors Essential for Mass Production of Synthetic Seeds in Banana

Hassanein A. M.,Ibrahiem I. A.,Galal A. A.,Salem J. M. M. The Korean Society of Plant Biotechnology 2005 Plant molecular biology and biotechnology research Vol.7 No.3

This work described some essential factors necessary for micro-propagation of banana for mass production of synthetic seeds for germ plasm conservation, and how peroxides activity of conserved tissue was influenced. Shoot tips of field grown plants were used to obtain shoot clusters on shoot proliferation medium (MS medium supplemented with 5 mg/l BAP). Using longitudinally-split shoot tip technique, 18720, 8640, 7488, 2016 plantlets were obtained from one shoot tip of Maghraby, Grand Naine, Balady, and Williams, respectively, in six subculture, one month each, on solid medium. Shoot tips excised from in vitro grown plantlets were encapsulated in calcium-alginate beads and stored at $4^{\circ}C$ for one month on half-strength MS basal medium without growth regulators or sugars. After one month all the viable-conserved synseeds formed shoots when they were transferred to MS basal medium, some of them showed synchronous formation of shoot and root systems in one week. Plants retrieved from encapsulated shoot tips were hardened off and transferred to soil.

Growth, yield, and quality of roselle (Hibiscus sabdariffa L.) plants as affected by nano zinc and bio-stimulant treatments

Yahya Zakaria Hassanein,S. S. A. Abdel-Rahman,Wagdi Saber Soliman,Sabri Salaheldin 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.6

Nanoparticles are one of the most widely studied materials in this century, and they have important uses in various fi elds,including agriculture. Bio-stimulants play a vital role in the sustainable development of horticultural crops. The aim of thisstudy was to assess the eff ect of nano zinc and bio-stimulants (salicylic acid, moringa extract, seaweed extract) on growth,yield, and quality of roselle plants. The experiment was conducted during 2018 and 2019 and was a completely randomizedsplit-plot design. Nano zinc oxide of 0, 5, 10, and 15 ppm was used as the main plot, and bio-stimulants were used as the subplot. The results showed that application of nano zinc led to signifi cant increases in growth, yield, photosynthetic pigments,as well as anthocyanin content associated with increased zinc content in leaves. The highest values of all traits occurredunder treatment of 10 ppm of nano zinc. Also, bio-stimulants showed positive eff ects on all traits, and the best results wereachieved under treatment with seaweed, followed by moringa extract. The correlation coeffi cients showed signifi cant positivecorrelations among calyxes yield and anthocyanin and zinc content as well as with other growth traits and photosyntheticpigments. These results highlighted the important role of nano zinc in improving the growth, yield, and quality of the roselleplant, as well as the positive eff ects of seaweed as a bioactive stimulant. Therefore, it is recommended to include nano zincand seaweed extract in fertilization programs for achieving a sustainable production system of such crops.

Comparison of Heat Transfer in Both the Riser and Downcomer of a Circulating Fluidized Bed

Soubhi A. Hassanein,O. M. Dahab 한국연소학회 2004 KOSCOSYMPOSIUM논문집 Vol.- No.-

An Algorithm for Selecting Clustering Attribute using Significance of Attributes

W. A. Hassanein,Amr A. Elmelegy 보안공학연구지원센터 2013 International Journal of Database Theory and Appli Vol.6 No.5