Apatinib as a Third-Line Treatment for HER2-Positive Metastatic Gastric Cancer: A Multi-Center Single-Arm Cohort Study

Zhang, Xin,Huo, Haoran,Nie, Yanan,Xue, Jiadong,Yuan, Zengjiang,Zhang, Zhenyi The Korean Gastric Cancer Association 2022 Journal of gastric cancer Vol.22 No.4

Purpose: Treatment options are limited after the failure of first-and second-line treatments in patients with HER2⁺ metastatic gastric cancer (mGC). The present study aimed to explore the efficacy, safety, and prognostic factors of apatinib efficacy as a third-line therapy for patients with human epithelial growth factor receptor 2-positive (HER2⁺) mGC. Materials and Methods: A total of 59 HER2⁺ mGC patients who received apatinib as third-line therapy were retrospectively enrolled in this two-center, single-arm, cohort study; the clinical response, survival data, and adverse events were retrieved. Results: The median progression-free survival (PFS) was 5.2 months (95% confidence interval [CI], 3.9-6.5), and the median overall survival (OS) was 8.2 months (95% CI, 6.6-9.8) Furthermore, forward stepwise multivariate Cox regression analysis showed that a higher Eastern Cooperative Oncology Group performance status score and multiple metastases were independently correlated with decreased PFS and OS (both P<0.05). The main adverse events were leukopenia (45.8%), hypertension (44.1%), thrombocytopenia (39.0%), hand-foot syndrome (37.3%), and elevated transaminase (33.9%). Grade 3 adverse events mainly included hypertension (5.1%) and neutropenia (5.1%); grade 4 adverse events did not occur. Conclusions: Apatinib is efficient and well tolerated in patients with HER2⁺ mGC as a third-line treatment, suggesting that it may be a candidate of choice for these patients.

PIV measurement and numerical investigation on flow characteristics of simulated fast reactor fuel subassembly

Zhang, Cheng,Ju, Haoran,Zhang, Dalin,Wu, Shuijin,Xu, Yijun,Wu, Yingwei,Qiu, Suizheng,Su, G.H. Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.5

The flow characteristics of reactor fuel assembly always intrigue the designers and the experimentalists among the myriad phenomena that occur simultaneously in a nuclear core. In this work, the visual experimental method has been developed on the basis of refraction index matching (RIM) and particle image velocimetry (PIV) techniques to investigate the detailed flow characteristics in China fast reactor fuel subassembly. A 7-rod bundle of simulated fuel subassembly was fabricated for fine examination of flow characteristics in different subchannels. The experiments were performed at condition of Re=6500 (axial bulk velocity 1.6 m/s) and the fluid medium was maintained at 30℃ and 1.0 bar during operation. As for results, axial and lateral flow features were observed. It is shown that the spiral wire has an inhibitory effect on axial flow and significant intensity of lateral flow mixing effect is induced by the wire. The root mean square (RMS) of lateral velocity fluctuation was acquired after data processing, which indicates the strong turbulence characteristics in different flow subchannels.

Strongly Fluorescent Carbon Quantum Dots from Biomass Tar as Highly Selective and Sensitive Probe for Fe3+ Detection

Haoran Yuan,Xian Zhang,Denian Li,Yong Chen 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.4

Nonhazardous and value-added utilization of biomass tar remains a great challenge in biomass gasification development. Herein, both model compounds and real biomass tar were for the first time tested as the carbon source for carbon quantum dots, where the resultants demonstrated excellent monodispersibility and strong fluorescence, quantum efficiency up to 53% and 43% were achieved. Moreover, the real tar-derived CQDs further revealed as a highly selective and sensitive probe for Fe3+, indicating its great potential ion sensing. It is expected that this work would open up a new strategy for biomass tar valorization.

IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis

Wang Haoran,Wu Tao,Hua Feng,Sun Jinpeng,Bai Yunfeng,Wang Weishun,Liu Jun,Zhang Mingshun 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.3

BACKGROUND: Recent evidence suggests that IL-33, a novel member of the IL-1b family, is involved in organ fibrosis. However, the roles of IL-33 and its receptor ST2 in epidural fibrosis post spine operation remain elusive. METHODS: A mouse model of epidural fibrosis was established after laminectomy. IL-33 in the wound tissues post laminectomy was measured with Western blotting, ELISA and immunoflurosence imaging. The fibroblast cell line NIH- 3T3 and primary fibroblasts were treated with IL-33 and the mechanisms of maturation of fibroblasts into myofibroblasts were analyzed. To explore roles of IL-33 and its receptor ST2 in vivo, IL-33 knockout (KO) and ST2 KO mice were employed to construct the model of laminectomy. The epidural fibrosis was evaluated using H&E and Masson staining, western-blotting, ELISA and immunohistochemistry. RESULTS: As demonstrated in western blotting and ELISA, IL-33 was increased in epidural wound tissues post laminectomy. The immunoflurosence imaging revealed that endothelial cells (CD31?) and fibroblasts (a-SAM?) were major producers of IL-33 in the epidural wound tissues. In vitro, IL-33 promoted fibroblast maturation, which was blocked by ST2 neutralization antibody, suggesting that IL-33-promoted-fibroblasts maturation was ST2 dependent. Further, IL-33/ ST2 activated MAPK p38 and TGF-b pathways. Either p38 inhibitor or TGF-b inhibitor decreased fibronectin and a-SAM production from IL-33-treated fibroblasts, suggesting that p38 and TGF-b were involved with IL-33/ST2 signal pathways in the fibroblasts maturation. In vivo, IL-33 KO or ST2 KO decreased fibronectin, a-SMA and collagen deposition in the wound tissues of mice that underwent spine surgery. In addition, TGF-b1 was decreased in IL-33 KO or ST2 KO epidural wound tissues. CONCLUSION: In summary, IL-33/ST2 promoted fibroblast differentiation into myofibroblasts via MAPK p38 and TGFb in a mouse model of epidural fibrosis after laminectomy.

Application and optimal design of the bionic guide vane to improve the safety serve performances of the reactor coolant pump

Liu Haoran,Wang Xiaofang,Lu Yeming,Yan Yongqi,Zhao Wei,Wu Xiaocui,Zhang Zhigang 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.7

As an important device in the nuclear island, the nuclear coolant pump can continuously provide power for medium circulation. The vane is one of the stationary parts in the nuclear coolant pump, which is installed between the impeller and the casing. The shape of the vane plays a significant role in the pump's overall performance and stability which are the important indicators during the safety serve process. Hence, the bionic concept is firstly applied into the design process of the vane to improve the performance of the nuclear coolant pump. Taking the scaled high-performance hydraulic model (on a scale of 1:2.5) of the coolant pump as the reference, a united bionic design approach is proposed for the unique structure of the guide vane of the nuclear coolant pump. Then, a new optimization design platform is established to output the optimal bionic vane. Finally, the comparative results and the corresponding mechanism are analyzed. The conclusions can be gotten as: (1) four parameters are introduced to configure the shape of the bionic blade, the significance of each parameter is herein demonstrated; (2) the optimal bionic vane is successfully obtained by the optimization design platform, the efficiency performance and the head performance of which can be improved by 1.6% and 1.27% respectively; (3) when compared to the original vane, the optimized bionic vane can improve the inner flow characteristics, namely, it can reduce the flow loss and decrease the pressure pulsation amplitude; (4) through the mechanism analysis, it can be found out that the bionic structure can induce the spanwise velocity and the vortices, which can reduce drag and suppress the boundary layer separation.

Mesocarbon microbead densified matrix graphite A3-3 for fuel elements in molten salt reactors

Wang, Haoran,Xu, Liujun,Zhong, Yajuan,Li, Xiaoyun,Tang, Hui,Zhang, Feng,Yang, Xu,Lin, Jun,Zhu, Zhiyong,You, Yan,Lu, Junqiang,Zhu, Libing Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.5

This study aims to provide microstructural characterization for the matrix graphite which molten salt reactors (MSRs) use, and improve resistance to molten salt infiltration of the matrix graphite for fuel elements. Mesocarbon microbeads (MCMB) densified matrix graphite A3-3 (MDG) was prepared by a quasi-isostatic pressure process. After densification by MCMBs with average particle sizes of 2, 10, and 16 ㎛, the pore diameter of A3-3 decreased from 924 nm to 484 nm, 532 nm, and 778 nm, respectively. Through scanning electron microscopy, the cross-section energy spectrum and time-of-flight secondary ion mass spectrometry, resistance levels of the matrix graphite to molten salt infiltration were analyzed. The results demonstrate that adding a certain proportion of MCMB powders can improve the anti-infiltration ability of A3-3. Meanwhile, the closer the particle size of MCMB is to the pore diameter of A3-3, the smaller the average pore diameter of MDG and the greater the densification. As a matrix graphite of fuel elements in MSR was involved, the thermal and mechanical properties of matrix graphite MDG were also studied. When densified by the MCMB matrix graphite, MDGs can meet the molten salt anti-infiltration requirements for MSR operation.

Experimental Investigation on the Properties of Sustainable Pervious Concrete with Different Aggregate Gradation

Junyu Zhang,Haoran Sun,Xiaotian Shui,Wenxuan Chen 한국콘크리트학회 2024 International Journal of Concrete Structures and M Vol.18 No.2

Pervious concrete (PC) as a green infrastructure material has been increasingly used due to its positive environmental impacts, such as controlling storm water runoff, removing water pollutants and reducing heat island effect. The aggregate gradation is a critical factor influencing the physical properties of PC. Therefore, this paper represents an attempt to determine the effects of aggregate gradation on the various physical properties of PC, and then to explore relationships between them. To this end, three aggregate gradations 4.75–9.5 mm, 9.5–19 mm and 19–31.5 mm were recombined with various proportions (20–80%) to obtain five different gradations named as A, B, C, D and E. PC mixtures were prepared with these five aggregate gradations. Then, physical and mechanical properties of PC including porosity, permeability, compressive strength and water stability were investigated, according to the available specification. The results suggested that it was feasible to use waste concrete for permeable pavement, because all the specimens provided required specification requirements. Different linear relationships were also found between the maximum aggregate size and porosity, permeability coefficient, compressive strength and its loss rate. That is, porosity and permeability increased with the proportion of larger size aggregate increased, however, compressive strength reduced. Thus the compressive strength had an inverse correlation with the porosity and water permeability. Among five different aggregate gradations, group C (20% of 4.75–9.5 mm aggregate, 50% of 9.5–19 mm aggregate and 30% of 19–31.5 mm aggregate) can be seen as the optimum gradation and is suitable for base layer materials of permeable pavements.

SYNTHESIS AND PROPERTY OF MULTIFUNCTIONAL Fe3O4@SiO2@CeO2@Au COMPOSITE MICROSPHERES

YANG WANG,HAORAN SUN,TONG ZHANG,ANJIAN XIE 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.6

In this paper, Fe3O4@SiO2@CeO2@Au core/shell microspheres were synthesized through hydrolysis and solvothermal processes. The results indicated that the magnetic Fe3O4 cores were well wrapped by the coating layer of SiO2/CeO2 with a thickness of 50 nm, and Au nanoparticles with 35 nm in diameter were attached on the shell. The microspheres showed a monodispersity and superparamagnetism. The composites showed excellent ability to absorb a wide range of wavelengths including visible and NIR region (from 250 nm to 800nm), making it a potential full solar spectrum response photocatalyst for sunlight applications.

The short-term impact of fine particulate matter pollution on the incidence of cardiovascular diseases in Beijing, China

Yuxia MA,Haoran JIAO,Yifan ZHANG,Bowen CHENG,Fengliu FENG 대한환경공학회 2019 대한환경공학회 학술발표논문집 Vol.2019 No.-

중국 스핀오프 웹예능 콘텐츠의 유형 연구: 추리 예능 〈명성대정탐〉과 〈밀실대탈출〉을 중심으로

곽호연(Guo Haoran),장문가(Zhang Wenjia) 한국콘텐츠학회 2023 한국콘텐츠학회논문지 Vol.23 No.12

최근 중국의 웹예능 프로그램에서는 예능 콘텐츠 및 IP를 확장하기 위해 다양한 스핀오프(spin-off) 예능 시리즈의 제작에 나서고 있다. 스핀오프 예능은 새로운 유형과 패턴을 바탕으로 독자적인 스토리월드와 IP까지 형성시키며 오리지널 예능과 함께 오리지널-스핀오프 예능이라는 IP 사슬을 형성시키는 것으로 더 큰 가치를 창출할 수 있다. 본고는 망고TV 〈명성대정탐(明星大偵探)〉과 〈밀실대탈출(密室大逃脫)〉 두 추리 예능에서 파생된 스핀오프 예능의 유형을 정리하여, 스핀오프 예능에서 오리지널 예능의 IP를 확장하는 새로운 방식을 탐색하였다. 그 결과, 중국 스핀오프 예능은 주로 원작 보완형, 출연자의 캐릭터지향형, 미션게임형, 플롯체험형 등 4가지 유형으로 나눌 수 있었다. 동시에 이는 파편화 전파, 멀티 프로그램 연동, 무대 전후의 장벽 해소 등 전파 특징을 가지고 있으며 게임 역할 중시, 오리지널 예능 세계관에 입각한 IP 확장, 팬들의 콘텐츠 생산참여를 통한 융합문화 집단 창조 등 내용적 특징을 보였다. In recent years, Chinese web variety programs have been producing various spin-off variety series to expand their variety content and IP. Spin-off shows create their own storyworlds and IP based on new types and patterns, and can create greater value by forming an IP chain of original and spin-off shows with the original shows. This paper summarizes the types of spin-off shows derived from two mystery shows, Mango TVs 〈Who’s the Murderer〉 and 〈Great Escape〉, and explores new ways to extend the IP of original shows in spin-off shows. The results show that Chinese spin-off shows are mainly divided into four types: original complementary, character-oriented, mission game, and plot experience. They are characterized by fragmented dissemination, multi-program integration, and the elimination of barriers before and after the stage, while content features include emphasis on the role of games, IP expansion based on the original entertainment worldview, and the creation of convergence culture groups through fans participation in content production.