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Jin, Haneul,Hong, Yongju,Yoon, Jisun,Oh, Aram,Chaudhari, Nitin K.,Baik, Hionsuck,Joo, Sang Hoon,Lee, Kwangyeol unknown 2017 Nano energy Vol.42 No.-
<P><B>Abstract</B></P> <P>Mixed metal alloy nanoframeworks have shown a great promise as electrocatalysts in water electrolyzers and fuel cells. Although a limited number of mixed metal alloy nanoframeworks have been synthesized through phase segregation of alloy phases and removal of a component, there remains a strong need for a straightforward and facile synthesis route to this important nanostructure. A wide avenue for nanoframework structures can be opened with a fail-proof method for edge-coating shape-controlled template nanoparticles. Herein, we demonstrate that lanthanide metal chlorides can selectively passivate facets of a Ni nanotemplate, leaving the edges for the growth of a secondary metal (M = Ir, Pt). The edge-deposited metal can be further in situ mixed with the underlying Ni phase to afford rhombic dodecahedral nanoframes of binary alloy phases, namely, IrNi (IrNi-RF) and PtNi (PtNi-RF). IrNi-RF showed excellent electrocatalytic activity for the oxygen evolution reaction (OER) in an acidic electrolyte, requiring and overpotential of only 313.6mV at 10mAcm<SUP>−2</SUP>. Furthermore, even after 5000 potential cycles in the OER, IrNi-RF underwent little performance loss with an overpotential of 329.3mV at 10mAcm<SUP>−2</SUP>, demonstrating excellent catalytic stability. The presence of highly active grain boundaries, agglomeration-free frame structures, as well as the presence of IrNi/IrO<SUB>x</SUB> interface might be responsible for the excellent electrocatalytic activity and stability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Facets of template Ni nanoparticle are passivated by lanthanide metal chlorides to induce selective deposition of Pt or Ir on the edges, resulting in IrNi and PtNi alloy frameworks. </LI> <LI> IrNi nanoframe exhibits a great oxygen evolution reaction (OER) performance in acidic electrolyte and retains five times higher current density than that of Ir/C after 5000 cycles at 1.53 V. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P> <B>Synthesis of MNi (M = Ir or Pt) nanoframe</B> <I> <B>via</B> </I> <B>facet-passivation agents</B> and its excellent electrocatalytic activity and durability to oxygen evolution reaction in acidic electrolyte.</P> <P>[DISPLAY OMISSION]</P>
Park, Hye Jin,Jung, In Ho,Kwon, Huiyoung,Yu, Jimin,Jo, Eunbi,Kim, Haneul,Park, Se Jin,Lee, Young Choon,Kim, Dong Hyun,Ryu, Jong Hoon Elsevier Ireland Ltd 2019 Journal of Ethnopharmacology Vol.233 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P>The seeds of Zizyphus jujuba var. spinosa (Bunge) Hu ex H.F. Chow (Rhamnaceae) have long been treated as hypnotic agent for sleep disturbances in traditional Chinese and Korean medicine and many previous studies have focused on its effect in central nervous system.</P> <P><B>Aims of study</B></P> <P>The present study aimed to provide evidence showing that the ethanol extract of <I>Zizyphus jujuba</I> var. <I>spinosa</I> seeds (EEZS), which may regulate plasmin activity, has the potential to serve as a therapeutic agent for AD.</P> <P><B>Materials and methods</B></P> <P>Synaptic function was determined by measuring long-term potentiation (LTP) in Shaffer-collateral pathway of the hippocampus. Protein levels of plasmin or plasminogen were examined using western blotting. Plasmin activity was measured using ELISA. Cognitive functions were measured using passive avoidance and object recognition tests in the 5XFAD mice.</P> <P><B>Results</B></P> <P>Our <I>in vitro</I> analysis revealed that EEZS-treated hippocampal slices from 5XFAD mice, a mouse model of AD, showed significantly higher long-term potentiation levels than did vehicle-treated hippocampal slices from 5XFAD mice (<I>P</I> < 0.05). Additionally, EEZS significantly elevated the plasmin level and activity in the hippocampal slices from 5XFAD mice (<I>P</I> < 0.05). Co-treating the slices with EEZS and 6-aminocaproic acid, a plasmin inhibitor, blocked the ameliorating effects of EEZS on the synaptic deficits that were present in 5XFAD mice. Compatible with the <I>in vitro</I> study, the results of our <I>in vivo</I> investigation showed that administering EEZS orally to 5XFAD mice ameliorated their memory impairments. Orally administered EEZS also elevated the plasmin level and activity in the hippocampus of 5XFAD mice.</P> <P><B>Conclusions</B></P> <P>Collectively, our findings suggest that EEZS alleviates the AD-like symptoms in 5XFAD mice by regulating of plasmin activity and EEZS may be a suitable treatment for AD.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jeon, Se Jin,Lee, Hong Ju,Lee, Hyung Eun,Park, Se Jin,Gwon, Yubeen,Kim, Haneul,Zhang, Jiabao,Shin, Chan Young,Kim, Dong Hyun,Ryu, Jong Hoon Elsevier 2017 NEUROPHARMACOLOGY - Vol.113 No.1
<P><B>Abstract</B></P> <P>Oleanolic acid is a naturally occurring triterpenoid and is widely present in food and medicinal plants. To examine the effect of oleanolic acid on memory deficits, we employed a cholinergic blockade-induced cognitive deficit mouse model. A single administration of oleanolic acid significantly increased the latency on the passive avoidance task and affected the alternation behavior on the Y-maze task and the exploration time on the novel object recognition task, indicating that oleanolic acid reverses the cognitive impairment induced by scopolamine. In accordance with previous reports, oleanolic acid enhanced extracellular-signal-regulated kinase 1/2 <B>(</B>ERK1/2) and cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the hippocampus. Interestingly, ameliorating effect of oleanolic acid on scopolamine-induced memory impairment was abolished by N2-(2-{[(2-oxoazepan-3-yl)amino]carbonyl}phenyl)benzo[<I>b</I>]thiophene-2-carboxamide (ANA-12), a potent and specific inhibitor of tropomyosin receptor kinase B (TrkB), in the passive avoidance task. Similarly, oleanolic acid significantly evoked long-term potentiation in a dose-dependent manner, which was diminished by ANA-12 treatment as shown in the electrophysiology study. Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Oleanolic acid activated the ERK1/2-CREB-BDNF pathway in the hippocampus via TrkB activation. </LI> <LI> Scopolamine-induced memory dysfunction was ameliorated by oleanolic acid treatment. </LI> <LI> Oleanolic acid evoked the long-term potentiation in a dose-dependent manner. </LI> <LI> Oleanolic acid would be a potential therapeutic agent for the cognitive problem. </LI> </UL> </P>
Selective area epitaxy of complex oxide heterostructures on Si by oxide hard mask lift-off
Ruiguang Ning,Soo Young Jung,Haneul Choi,Byeong-hyeon Lee,Min-Seok Kim,Hyung-Jin Choi,Jun Young Lee,Jin Soo Park,Sung-Jin Jung,Ho Won Jang,Sung Ok Won,Hye Jung Chang,Ji-Soo Jang,Kyu Hyoung Lee,Byung C 대한금속·재료학회 2023 ELECTRONIC MATERIALS LETTERS Vol.19 No.2
Epitaxial complex oxide heterostructures on Si are an excellent platform for the realization of multifunctional electronicdevices to exploit the unique functionalities of the oxides that Si does not possess. It is often necessary to make patternsof epitaxial films on selected areas of Si. Here, a path towards the selective area epitaxial growth of complex oxide heterostructureson Si using a hard mask lift-off technique is reported. A water-soluble oxide (Sr3Al2O6) is used as a lift-offhard mask that can survive the high temperature (~ 750 °C) and oxidizing environments for epitaxial oxide growth and beselectively etched away subsequently using deionized water. It is found that the epitaxial growth of yttria-stabilized zirconia(YSZ) buffer layers on Si is very sensitive to organic residues formed during photolithography. Island patterns of epitaxial(La, Sr)MnO3/CeO2/YSZ heterostructures are successfully fabricated on Si through the use of oxygen plasma treatment toremove residues. A simple and low-cost method to pattern complex oxide single crystals integrated on Si for the realizationof multifunctional oxide-integrated electronics is provided in this study.
3차병원 중환자실 내 전향적 감사와 피드백을 통한 항생제 사용 중재 효과
윤진구,최하늘,김성란,조민희,최유정,남엘리엘,성혜,노지윤,정희진,김우주,송준영 건강보험심사평가원 2023 HIRA RESEARCH Vol.3 No.2
Background: The implementation of antibiotic stewardship program (ASP) has been encouraged in developed countries in response to increasing antibiotic resistance. However, the implementation of ASP has been limited owing to a lack of manpower and awareness. We aimed to analyze the effectiveness of prospective audit and feedback (PAF), one of the core strategies in ASP, by applying it to the intensive care units (ICUs). Methods: In this study, we applied PAF to the neurological/surgical ICUs of a tertiary hospital starting from March 1, 2023, we compared the data of 6 months before (from September 2022 to February 2023) and after (from March 2023 to August 2023) the implementation to assess the difference in antimicrobial use density (AUD) and the acquisition rates of antibiotic-resistant bacteria. Furthermore, we surveyed the satisfaction of PAF using a questionnaire. PAF was conducted twice a week during rounds by the ASP team, which consisted of an infectious disease specialist and one assistant. Results: Before and after the implementation of PAF, AUD showed a tendency to decrease in the classes of beta-lactam/beta-lactamase inhibitors, cephalosporins and glycopeptides, although the changes were not statistically significant. The acquisition rate of carbapenem-resistant Acinetobacter baumannii decreased slightly in the surgical ICU. Most participating interns and residents reported that PAF was clinically and educationally helpful in the survey. Conclusion: Implementing PAF twice a week in the neurological/surgical ICUs could reduce antibiotic usage and the acquisition rates of some resistant bacteria.