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한슬기,김명주 서울여자대학교 컴퓨터과학연구소 2016 정보기술논문지 Vol.14 No.-
IT 산업을 이끌어갈 차세 기술로 가 주목받고 있다 는 홈네트워크 헬스어 제조 공공안 의 료 등 다양한 분야에서 사용되고 있다 는 기본으로 소형화 고성능력화 가격화 그리고 표화를 목표로 개 발된다 특히 자원의 제약이 있는 배터리 하드웨어와 같은 작은 디바이스들은 에지 효율성을 특히 요시한다 이 때 문에 각 제조사들은 소형화 력화된 제품을 생산해 내는 것에 주력하고 있는 상황이므로 상으로 보안이 취약 하다는 문제이 동시에 존재한다 본 논문에서는 디바이스들 에서도 배터리를 소모하여 동작하는 소형 디바이스에 서 사용되는 기술 취약에 해 반으로 살펴보고 소형 기기들의 보안취약 사례를 분석함으로써 소형 디바이 스들의 보안의 필요성과 요성을 제시한다
류한영,설정현,김정철,한승세,우상현,최시호 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2
Bronchopleural fistula and chronic empyema are the difficult problems in the thoracic surgery field. We experienced 3 cases of chronic empyema and complicated bronchopleural fistulas treated with muscle flap and concomitant thoracoplasty. The causative primary diseases were pulmonary tuberculosis and bronchiectasis. All the three cases have failed to control the chronic empyema and bronchopleural fistula with conventional method such as closed or open drainage and Eloesser flap after lobectomy. The unresponsive infection on bronchopleural fistula and pleural space was well controlled after muscle flap with thoracoplasty. Complete decortication, closure of bronchopleural fistula as much as possible and coverage of closed fistula with good vascularized tissue are the essential factors for the success of operation on chronic empyema and bronchopleural fistula. The results of operations were satisfactory and the respiratory function was well preserved or improved in one patient. But, the contour of chest wall was deformed in patient with extensive concomitant thoracoplasty.
Seul Chan Park,Seong-Kyoon Choi,Se-Hyeon Han,Song Park,Hye Jin Jeon,Seung Chan Lee,Kyeong Yeon Kim,Young Seo Lee,김지형,Jee Eun Han 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.2
In this study, whiteleg shrimp (Penaeus vannamei) imported from Vietnam were collected from South Korean markets, and examined for 2 viruses: infectious hypodermal and hematopoietic necrosis virus (IHHNV, recently classified as decapod penstyldensovirus-1), and white spot syndrome virus (WSSV). Among 58 samples, we detected IHHNV in 23 samples and WSSV in 2 samples, using polymerase chain reaction and sequencing analyses. This is the first report of IHHNV and WSSV detection in imported shrimp, suggesting that greater awareness and stricter quarantine policies regarding viruses infecting shrimp imported to South Korea are required.
Practical Direction of Arrival Estimator using Constrained Robust Kalman Filtering
Seul-Ki Han,Won-Sang Ra,Jin Bae Park 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10
This paper proposes a linear estimation theory based direction of arrival (DOA) estimator to guarantee highperformance and computational efficiency. To do this, state-space system is derived from the linear prediction relation of the sinusoidal acoustic signal. Since it contains uncertain measurement matrix, the recently developed non-conservative robust Kalman filter (NCRKF) can be applied to compensate the performance degradation by the uncertain measurement matrix. However, unfortunately, the statistical information used in NCRKF scheme may not be precise in actual situation and it leads to the performance degradation. Therefore, in this paper, constrained NCRKF (CNCRKF) is presented to develop practical DOA estimator. It adopts constraint condition derived from the relation between target states to solve the performance degradation problem by the incorrect statistical information. The performance of the proposed solution is demonstrated by the computer simulation.
Establishment of Hepatoma Treatment Model Using Hepatoma Cell Spheroids
( Han Seul Park ),( Jae Young Jang ),( Seoung Won Jeong ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang-woo Cha ),( Young Seok Kim ),( Young Deok Cho ),( Hong Soo Kim ),( Boo Sung Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Three dimensional (3D) spheroid cells are more closely mimic natural tissues and organs than cells grown in 2D. ``Biocompatible spheroidal hepatoma cell`` is thought to be closest model of real patient``s HCC. We have made spheroidal hepatoma cells using the proven technology and already confirmed apoptotic effect of ginsenoside Rh2 and Rg5 on 2D cells (Huh7 and Huh7.5.1). In this study, we investigate apoptotic effects of ginsenoside Rh2 and Rg5 using 3D hepatoma cell spheroids. Methods: Huh7 and Huh7.5.1 cells were maintained in culture dishes in RPMI supplemented with 10% inactivated fetal bovine serum (FBS) and DMEM supplemented with 10 % dialyzed FBS, respectively. When they reached about 80 % confluence, cells were harvested from 2-D petri-dish cultures by treatment with trypsin. These cells cultured in 1.5 % soft agarose gels for 10-14 days. After 10-14 days, 3-D hepatic structure was formed and treated with ginsenoside Rh2 (100, 200uM) and Rg5 (10, 50, 100uM) for 72h. Comparison between 2-D and 3-D models was done with microscopic and protein analysis. Results: The behaviors of 2D and 3D cells (Huh7 and Huh7.5.1, respectively) have been shown different morphologic change. 3-D culture of Huh7 and Huh7.5.1 cells had a longer survival time rather than 2-D cell model. The response to ginsenoside Rh2 and Rg5 on 3D culture systems showed a lower cell death rate compared with 2D culture systems. The expression of cleaved PARP protein was increased in both 2D and 3D cells with exposure to ginsenoside Rh2 and Rg5. Conclusions: Hepatoma cell sheroids had a longer survival time and a similar apoptotic effect compared to 2-D cell model in drug screening. It is expected to have an important role on the drug screening and treatment prediction in HCC.
( Han Seul Park ),( Jae Young Jang ),( Soung Won Jeong ),( Jeong-ju Yoo ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang-woo Cha ),( Young Seok Kim ),( Young Deok Cho ),( Hong Soo Kim ),( So Young Jin ),( 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Animal & cell models of hepatoma give a crucial information, not only pathogenesis of liver cancer but also therapeutic effects of various agents. In this study, we investigate therapeutic effects of ginsenoside Rh2 and Rg5 using animal & cell models of hepatoma comparing with sorafenib. Methods: Huh7 & huh7.5.1 cells were harvested from 2-D petri-dish and cultured in 1.5 % soft agarose gels for 10-14 days. After 10-14 days, 3-D hepatic structure was formed and treated with ginsenoside Rh2 (100, 200uM) and Rg5 (10, 50, 100uM) for 72h. Hep3b cells (2×10<sup>5</sup>) in matrigel were suspended in 100 μl of phosphate-buffered saline (PBS) and then injected into the flanks of BALB/C nude mouse at 6 weeks. Sorafenib (10mg/kg), ginsenoside Rh2 (100 uM) and Rg5 (100 uM) was injected to intra-peritoneum twice a week. After 4 weeks, all mice were sacrificed and tumor tissue was collected. The tissue was stained with hematoxylin and eosin and histological evaluation was conducted by blindly pathologist. Area of necrosis and vascular change in tumor tissue was calculated using the lasso tool to encircle the area in ZEN 2011 Imaging Software. Results: Both ginsenoside Rh2 and Rg5 induced cell necrosis in hepatocellular carcinoma (HCC) cell lines, and more necrosis occurred in 2D models. The expression of cleaved PARP protein was increased in both 2D and 3D cells with exposure to ginsenoside Rh2 and Rg5. The hepatocellular carcinoma was confirmed in hepatoma mouse models by H&E stain. Increased necrosis and telangiectasia were observed in mice treated with sorafenib, Rh2, and Rg5 compared to control mouse. Conclusions: Our findings provide insight into the use of xenograft mouse as models of HCC and ginsenoside Rh2 & Rg5 might be a potential treatment candidate of liver cancer.