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프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성
최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1
Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.
나병곤,배학연,조현진,김권천 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.3
Purpose: Papillary thyroid microcarcinoma (PTMC) is increasing in incidence because of ultrasound-guided fine-needle aspiration cyology (FNA). According to WHO, PTMC is defined as a papillary thyroid cancer of 1 cm or less in diameter. Within the group of patients with PTMC, prognosis is known to be very favorable. This study was carried out to evaluate the clinicohistological characteristics of PTMC and to determine a reasonable extent of surgery for them. Methods: From Mar. 2002 to Dec. 2007, 610 patients with thyroid diseases underwent thyroidectomy at Chosun University hospital. Among these patients, 205 patients (33%) had a thyroid papillary carcinoma less than or equal to 1 cm in great diameter. The clinicopathologic features and treatment outcome of these patients were evaluated retrospectively. Results: In the period 2002-2007, PTMC incidence rate in our institution increased from 10% to 20%. There were 19 men and 186 women with a median age of 46 years (range; 16-74). PTMC diameter ranged from 0.1 to 1 cm. (mean 0.54 cm) 15.7% of patients with PTMC presented with preoperative symptoms (palpable mass, fatigue, pain, hoarseness). Preoperatively 84.3% of these 205 cases were diagnosed by ultrasonography. We performed unilateral lobectomy (41%), near total thyroidectomy (44%), and total thyroidectomy (11%) with or without central compartment neck node dissection. During a mean follow-up of 36 months, 5 patients (2.4%) developed locoregional recurrence with no distant metastasis. There were no significant difference on recurrence rate by size, capsular invasion. But multiplicity of primary tumor has a higher locoregional recurrence rate (p= 0.04). The detection rate of PTMC is increasing due to FNA technique in our hospital. This study shows that PTMC may have capsular invasion, lymph node involvement, multiplicity and locoregional recurrence likely to larger (>1 cm) papillary carcinoma. Conclusion: We suggest that total or near total thyroidectomy with central compartment neck dissection is proper therapeutic operation for PTMC and modified neck dissection shoud be performed if lateral neck lymph node are enlarged or diagnosed as metastatic tumor.
Enzymatic Saccharification of Salix viminalis cv. Q683 Biomass for Bioethanol Production
Kim, Hak-Gon,Song, Hyun-Jin,Jeong, Mi-Jin,Sim, Seon-Jeong,Park, Dong-Jin,Yang, Jae-Kyung,Yoo, Seok-Bong,Yeo, Jin-Ki,Karigar, Chandrakant S.,Choi, Myung-Suk Institute of Forest Science 2011 Journal of Forest Science Vol.27 No.3
The possibility of employing biomass of Salix viminalis cv. Q683 as a resource of bio-energy was evaluated. The chemical analysis of S. viminalis cv. Q683 leaf biomass showed components such as, extractives (2.57%), lignin (39.06%), hemicellulose (21.61%), and cellulose (37.83%), whereas, its stem was composed of extractives (1.67%), lignin (23.54%), hemicellulose (33.64%), and cellulose (42.03%). The biomass of S. viminalis cv. Q683 was saccharified using two enzymes celluclast and viscozyme. The saccharification of S. viminalis cv. Q683 biomass was influenced by enzymes and their strengths. The optimal enzyme combination was found to be celluclast (59 FPU/g substrate) and viscozyme (24 FBG/g substrate). On saccharification the glucose from leaf and stem biomass was 7.5g/L and 11.7g/L, respectively after 72 hr of enzyme treatment. The biomass and enzyme-treated biomass served as the feedstock for ethanol production by fermentation. The ethanol production from stem and leaf biomass was 5.8 g/L and 2.2 g/L respectively, while the fermentation of the enzymatic hydrolysates yielded 5 g/L to 8 g/L bioethanol in 72 hours.
A Real-Time Virtual Re-Convergence Hardware Platform
Kim, Jae-Gon,Kim, Jong-Hak,Ham, Hun-Ho,Kim, Jueng-Hun,Park, Chan-Oh,Park, Soon-Suk,Cho, Jun-Dong The Institute of Electronics and Information Engin 2012 Journal of semiconductor technology and science Vol.12 No.2
In this paper, we propose a real-time virtual re-convergence hardware platform especially to reduce the visual fatigue caused by stereoscopy. Our unique idea to reduce visual fatigue is to utilize the virtual re-convergence based on the optimized disparity-map that contains more depth information in the negative disparity area than in the positive area. Our virtual re-convergence hardware platform, which consists of image rectification, disparity estimation, depth post-processing, and virtual view control, is realized in real time with 60 fps on a single Xilinx Virtex-5 FPGA chip.
Bioethanol production from enzymatically saccharified Salix viminalis var. gigantea Leaf and stem.
( Hak Gon Kim ),( Hyun Jin Song ),( Mi Jin Jeong ),( Seon Jeong Sim ),( Young Long Seo ),( Hyun Jeong Im ),( Jae Kyung Yang ),( Seok Bong Yoo ),( Myung Suk Choi ) 한국임학회 2012 한국임학회 학술발표논문집 Vol.2012 No.-
Propagation by Leafy Stem Cuttings Containing Xylem of Populus alba × P.glandulosa Clone Bongwha1
Hak Gon Kim,Seong Hyeon Yong,김형호,최명석 강원대학교 산림과학연구소 2022 Journal of Forest Science Vol.38 No.4
The study was conducted to establish a method for the proliferation of hybrid poplar (P. alba × P. glandulosa) clone Bongwha1, an excellent biomass species. It was found that to collect the cuttings of Bonghwa1, it was necessary to use the main stem rather than the axillary branch. Stem growth by green-wood cuttings showed a tendency to decrease as the length of the collected cuttings increased, but the survival rate was low. Therefore, modified leafy stem cutting was attempted to increase the survival rate of the cuttings. In the modified leafy stem cutting method, 4 leaves were included in the cuttings, and especially, cuttings were performed using cuttings containing 2-4 cm xylem parts. Leafy stem cutting increased root growth and the number of stems, as well as the survival rate of hybrid poplar clone Bongwha1 compared to green-wood cuttings. The root growth of the leafy stem cutting poplar was better as there was more xylem part. Using two-year-old nursery stocks, the leafy stem cutting was used to produce about 66 cuttings. This study is expected to contribute to the mass propagation of high-quality nursery stocks.
Enzymatic Saccharification of Salix viminalis cv. Q683 Biomass for Bioethanol Production
Hak-Gon Kim,Hyun-Jin Song,Mi-Jin Jeong,Seon-Jeong Sim,Dong-Jin Park,Jae-Kyung Yang,Seok-Bong Yoo,Jin-Ki Yeo,Chandrakant S. Karigar,Myung-Suk Choi 강원대학교 산림과학연구소 2011 Journal of Forest Science Vol.27 No.3
The possibility of employing biomass of Salix viminalis cv. Q683 as a resource of bio-energy was evaluated. The chemical analysis of S. viminalis cv. Q683 leaf biomass showed components such as, extractives (2.57%), lignin (39.06%), hemicellulose (21.61%), and cellulose (37.83%), whereas, its stem was composed of extractives (1.67%), lignin (23.54%), hemicellulose (33.64%), and cellulose (42.03%). The biomass of S. viminalis cv. Q683 was saccharified using two enzymes celluclast and viscozyme. The saccharification of S. viminalis cv. Q683 biomass was influenced by enzymes and their strengths. The optimal enzyme combination was found to be celluclast (59 FPU/g substrate) and viscozyme (24 FBG/g substrate). On saccharification the glucose from leaf and stem biomass was 7.5g/L and 11.7g/L, respectively after 72 hr of enzyme treatment. The biomass and enzyme-treated biomass served as the feedstock for ethanol production by fermentation. The ethanol production from stem and leaf biomass was 5.8 g/L and 2.2 g/L respectively, while the fermentation of the enzymatic hydrolysates yielded 5 g/L to 8 g/L bioethanol in 72 hours.
Kim, Tae Gon,Hur, Su Won,Kim, Yong-Ha,Lee, Jun Ho,Mun, Ki Hak The Korean Society for Microsurgery 2015 Archives of reconstructive microsurgery Vol.24 No.1
The authors had five cases of penoplasty from more than half of the scrotum to the suprapubic region using a fasciocutaneous radial forearm free flap (RFFF) after extensive excision of sclerosing lipogranuloma. Although the harvested RFFF was a rectangular shape, the authors made the shape of scrotum, penile shaft, and suprapubic region by using well designed geometry and several quilting sutures on junction of scrotum and penis. The contour of scrotum and penis was well maintained, and there were no complications, such as scrotal contracture, penile deformity, and erectile dysfunction during the one year follow up period in all five cases. There were no recurrent lesions and no need for further surgery.
KIM, Hak Gyoon,Kim, Sang Soo,Choi, Hee Gu,Lee, Pil Yong,Moon, Hyo Bang,Ok, Gon 한국수산학회 2001 Fisheries and Aquatic Sciences Vol.4 No.2
Eight chlorobenzenes (out of a total of 12 in the congener series) were measured in the sediments from 21 stations in the southeastern coastal areas of Korea. The levels of total chlorobenzene isomers varied between 2.08 and 12.45 ng/g dry weight. The highest contents of total chlorobenzenes (CBs) were found in the sediments from Pohang coast. Trichlorobenzenes (the sum of 1,3,5-, 1,2,4- and 1,2,3-trichlorobenzene) were dominant classes among four congeners, whereas tetrachlorobenzenes (the sum of 1,2,3,5-, 1,2,4,5- and 1,2,3,4-tetrachlorobenzene) and pentachlorobenzene were low levels. The contributions of total CBs showed similar patterns for all stations with positive significant correlation within CBs species. It means that CBs contamination in the southeastern coasts of Korea came from the similar source.