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- 저자 : Hajimu Yamamoyo (검색결과 1 건)
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Yeunhwa Gu,Ikukatsu Suzuki,Motoki Koide,Ikuo Hayash,Hideyuki Takai,Ahn,Kyoo-seok,Hajimu Yamamoyo INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 1999 JOURNAL OF ORIENTAL MEDICINE Vol.4 No.1
Propolis is a resin-like material produced by honeybees, an mixture with resin and pollen in their saliva. Propolis, in Oriental medicine, has been referred to as 'Nobongbang'(露蜂房)and used for anti-pyretic, antidotal, analgesic, and anti-inflammatory purpose. The pharmacological effects of Propolis are known to be anti-bacterial, anti-inflammatory, anti-tumor, and immunopotentiating. Propolis was extracted with water, the extract was centrifuged, and the supernatant was filtered and freeze-dried. It was then gel-filtered and purified according to the increase in the ratio of mouse lymphocytes versus polymorphonuclear leukocytes(L/P activity). We previously reported the immunopotentiating effects of Propolis at the 114the General Conference of the Japan Society of Pharmacology(March, 1994 : Tokyo) and its anti-tumor effects on solid and ascitic tumors in mice bearing Ehrlich carcinoma at the 53rd General Conference of the Japanese Cancer Association(October, 1994 : Nagoya). Furthermore we reported the anti-tumor and anti-cytopenic effects of combined use of water-soluble Propolis and its gel-filtration fractions G-1, G-2, and G-3 with anti-cancer drugs(5FU and MMC) in ICR mice(5-week-old males) bearing Ehrlich carcinoma at the 115th General Conference of the Japan Society of Pharmacology(March, 1995 : Sendai). The tumor growth was inhibited, and cytopenia due to 5FU was significantly alleviated(Pr.<0.01 for WBS and RBC), when water-soluble Propolis was administered with 5FU as compared with 5FU alone(inhibition rate 83.0%). When water-soluble Propolis and its gel-filtration fractions G-1 and G-2 were administered with MMC, the tumor growth was more suppressed(inhibition rates 91.8%, 88.0%, and 82.0%, respectively) than by intraperitoneal administration of MMC alone. In addition, leukopenia was significantly alleviated(Pr.<0.05) by administration of water-soluble and G-2 with MMC as compared with MMC alone(54th General Conference of the Japan Cancer Society : Oct., 1995 : Kyoto). Aithouse, the active component responsible for the anti-tumor activity of water-soluble Propolis has been identified, and its anti-tumor effects likely to be derived from stimulation of host responses as well as direct effects on cancer cells, because water-soluble Propolis and its gel-filtration fractions increased the L/P activity and antibody-producing cells(PFC activity). Water-soluble Propolis, G-1 and G-2 had preventive effects on cytopenia induced by anti-cancer drugs, probably because they exert stimulatory effects on hemopoietic functions via cytokines such as IL-6 and IL-11. We intended to analyze components of G-1 and G-2, which showed potent anti-tumor effects, by high-performance liquid chromatography.
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