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Chung, J.Y.,Kitano, H.,Takikita, M.,Cho, H.,Noh, K.H.,Kim, T.W.,Ylaya, K.,Hanaoka, J.,Fukuoka, J.,Hewitt, S.M. W. B. Saunders Co ; Centrum Philadelphia 2013 Human pathology Vol.44 No.4
Synaptonemal complex protein 3 is a marker for cell transformation that has prognostic significance in various cancers. However, the prognostic significance of synaptonemal complex protein 3 has not been studied in non-small cell lung cancer. To investigate the potential correlation between synaptonemal complex protein 3 and various clinicopathologic parameters, we assessed the expression of synaptonemal complex protein 3 in archival tumor tissues from 258 patients with non-small cell lung cancer by immunohistochemical staining. By immunofluorescence, synaptonemal complex protein 3 was detected in both the cytoplasmic and nuclear fractions of NCI-H1299 cell. In tumor samples, synaptonemal complex protein 3 is detected as cytoplasmic expression pattern and observed in 50 clinical samples (19.4%) by immunohistochemical staining. Synaptonemal complex protein 3 expression was correlated with T status (P = .008), lymph node metastasis (P = .010), tumor types (P = .019), and pleural invasion (P = .005). In multivariate analysis of patients with early stage disease, increased synaptonemal complex protein 3 expression predicted worse overall survival in early stage (stage I and II) with pT1 status (P = .041). These results suggest that positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival and may provide clues in the identification of patients for adjuvant therapy.
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Flehmen Induction with Goats by the Urine of Twenty Animal Species
Kanomata, K],Fukuoka, T,Sasada, H,Masaki, J,Kang, M.S 제주대학교 1988 논문집 Vol.26 No.-
Flehmen은 많은 동물에 있어 求愛과정중에 흔히 볼 수 있는 반응으로 알려져 있다. 反雛動物에 대한 최근의 연구에서 flehmen은 鋤鼻器官에 대해 어떤 pheromone 물질을 운반하는 메키니즘에 수반된 것일지도 모른다고 시사하고 있다. 그래서 이들 변화는 발정 발견을 위해 이용될 수 있을 것으로 생각 되었다. 本 實驗은 다른 동물의 尿가 같은 동물의 尿처럼 flehmen을 誘起할 수 있을지 확인하기 위하여 Saanen과 이들 雜種인 雄山羊 8頭, 雌山羊 3頭, 去勢한 山羊 3頭를 공시하였다. 尿는 15種의 哺乳動物, 3種의 鳥類,2種의 파충류 등 모두 20種을 채취하여 실험할 때까지 냉동 보존 했다. 尿는 주로 코에 spray 해주었으나 약간 굳어 있는 것에 대해서는 코로 냄새를 맡게 했다. flehmen 지속시간은 0,1-9, 20-39 및 40초 이상 등 네가지로 구분 기록하였다. 각각의 尿는 어느 山羊에 있어서도 반응을 일으켰다. Sample 間 및 번식주기에 따라 강도에 많은 차이를 나타냈다. 개체 차이가 현저했음에도 불구하고 일반적으로 雄山羊은 雌山羊보다 더 강한 반응을 보였다. 거세산 山羊은 중간형을 나타냈다. Antiandrogen을 주사한 雄山羊의 반응은 억제되는 경향이었다. 이 결과는 산양에서 flehmen이 同種에서 처럼 다른 種의 尿로 부터도 誘起될 수 있다는 것과 그리고 androgen은 이 반응을 조절하는 factor의 하나일지도 모른다는 것을 시사했다. Flehmen is well-known response which often occures during the process of courtship in most mammals. Recent studies with domestic ruminants suggest that the flehmen may be involved in the mechanism of transferring some pheromonal substances to vomeronasal organ. Thus, variety of its significance has been supposed, besides that male animals may use it for estrus detection. In this experiment, 8 male, 3 female and 3 castrated goals of Saanen and its hybrid were used to ascertain whether urine from alien species can induce flehmen as that from same species. Urine was collected from twenty species consisting of 15 mammals. 3 birds and 2 reptiles and frozen until use. Mostly urine was sprayed to the nose of goats, but some coagulated ones were sniffed. Duration of flehmen was scored to four ranks as 0, 1-19, 20-39 and >40 sec. Each urine sample induced the response in any goats. However, much differnce in the intensity was found between the samples and according to the reproductive state of the receptor goats. Although individual difference was manifest, male goats generally showed more intense respomse than did female. Castrated goats showed the intermediate pattern. Administration of antiandrogen to the male goat tended to reduce the response. The results indicate that flehmen in the goat could occur for the urine of alien species as that of same species and the androgen may be one of factors regulating the response.
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Flehmen Induction with Goats by the Urine of Twenty Animal Species
Kang, M.S.,Sasada, H.,Kanomata, K.,Fukuoka, T.,Masaki, J. 제주대학교 농과대학 제주도축산문제연구소 1989 畜産論叢 Vol.4 No.1
Flehmen is well-known response which often occurs during the procesa of courtship in most mammals. Recent studies with domestic ruminants suggest that the flehmen may be involved in the mechanism of transferring some pheromonal substances to vomeronasal organ. Thus, variety of its significance has been supposed, besides that male animals may UK it for estrus detection. In this experiment, 8 male, 3 female and 3 castrated goats of Saanen and its hybrid were used to ascertain whether urine from alien species can induce flehrnen aa that from same species. Urine was collected from twenty species consisting of 15 mammals, 3 birds and 2 reptiles and frozen until UM. Mostly urine was sprayed to the nose of goats, but some coagulated ones were miffed. Duration of flehmen was scored to our ranks as 0, l-19, 20-39 and > 40 sec. Each urine sample induced the response in any goats. However, much difference in the in-tensity was found between the samples and according to the reproductive state of the receptor goats. Although individual difference was manifest, male goats genenlly showed more intense response than did female. Castrated goats showed the intermediate pattern. Administration of antiandrogen to the male goat tended to reduce the response. The results indicate that flehmen in the goat could occur for the urine of alien species as that of same species and the androgen may be one of the factors regulating the response.
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