Clinical Usefulness of Korean Red Ginseng in Postmenopausal Women with Severe Climacteric Disturbance

Yoshihiro Kikuchi(Yoshihiro Kikuchi),Takehiko Tode(Takehiko Tode),Junko Hirata(Junko Hirata),Hideyuki Nakata(Hideyuki Nakata),Tsunekazu Kita(Tsunekazu Kita) 고려인삼학회 2003 Journal of Ginseng Research Vol.27 No.3

The aim of this study is to evaluate clinical usefulness of Korean red ginseng (RG) on various postmenopausal syndromes. Total plasminogen inhibitor-1 (tPAI-1) in peripheral blood from 9 postmenopausal women with climacteric syndromes (CS) was measured before and 3 months after treatment with daily oral administrat i on of 6g RG and that from 8 postmenopausal women without any CS was also measured as healthy controls. Blood samples were collected in the early morning on the bed-rest. Psychological conditions of postmenopausal women with CS were measured before and 3 months after treatment with RG using simplified menopausal index (SMI). In addition, OKETSU (blood stagnation) syndrome scores and KI deficiency (generalized energy stagnation) scores proposed by Terasawa et al., were recorded before and 3months after treatment with RG in postmenopausal women with CS and in healthy postmenopausal women. OKETSU syndrome scores and tPAI-1 levels in postmenopausal patients with CS were significantly (P<0.001 and<br/> P<0.01) higher than those in healthy postmenopausal women without CS. Similarly, SMI scores and KI deficiency scores in postmenopausal patients with CS were about three-fold higher than those without any CS. When RG was administered for 3 months, KI deficiency scores and OKETSU scores as well as SMI scores declined around the levels of healthy postmenopausal women. Although tPAI-1 levels significantly (P<0.05) decreased after treatment with RG, those did not reach the levels of healthy postmenopausal women. Clinical usefulness of administration of RG to postmenopausal women with CS was confirmed from evaluation not only by modern medicine but also by traditional KAMPO medicine.

전기산업의 에너지문제 해결방안

Kikuchi K 한국에너지협의회 1995 에너지協議會報 Vol.36 No.-

A 1-megadalton translocation complex containing Tic20 and Tic21 mediates chloroplast protein import at the inner envelope membrane.

Kikuchi, Shingo,Oishi, Maya,Hirabayashi, Yoshino,Lee, Dong Wook,Hwang, Inhwan,Nakai, Masato American Society of Plant Physiologists 2009 The Plant cell Vol.21 No.6

<P>Chloroplast protein import is mediated by two hetero-oligomeric protein complexes, the Tic and Toc translocons, which are located in the inner and outer envelope membranes. At the inner membrane, many Tic components have been identified and characterized, but it remains unclear how these Tic proteins are organized to form a protein-conducting channel or whether a stable Tic core complex that binds translocating preproteins exists. Here, we report the identification of a 1-megadalton (MD) translocation complex as an intermediate during protein translocation across the inner membrane in Arabidopsis thaliana and pea (Pisum sativum). This complex can be detected by blue native PAGE using the mild detergent digitonin without any chemical cross-linkers. The preprotein arrested in the 1-MD complex can be chased into its fully translocated form after a subsequent incubation. While Tic20 and Tic21 appear to be involved in the 1-MD complex, Tic110, a well-characterized Tic component, exists as a distinct entity from the complex. Several lines of evidence suggest that the 1-MD complex functions in between the Toc and Tic110-containing complexes, most likely as a protein-conducting channel at the inner envelope.</P>

Future landscape visualization using a city digital twin: integration of augmented reality and drones with implementation of 3D model-based occlusion handling

Kikuchi Naoki,Fukuda Tomohiro,Yabuki Nobuyoshi 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.2

The integration of augmented reality and drones allows past and future landscapes to be visualized from an aerial perspective. However, these visualizations still suffer from the occlusion problem, where the three-dimensional (3D) virtual model displayed in the real world is in front of a real-world object. Currently, city digital twins are essential for the sustainable development of cities and the development of detailed 3D models of cities. By visualizing the city digital twin, augmented reality can facilitate the participation of nonexpert citizens in the decision-making process of urban design, but research examples are limited. Here, using detailed city 3D models, we develop a digital-twin approach to outdoor augmented reality with occlusion handling for both first-person and bird’s-eye views. In a verification experiment, the occlusion handling accuracy of the prototype system was measured to be about 0.8 using intersection over union. The frame rate of the entire prototype system was about 30 fps, and the delay between the controller and the augmented reality device was about 3 s. The internet-based system architecture was developed to integrate augmented reality and drone systems. Our system allows multiple stakeholders involved in building construction projects to observe aerial perspectives of those projects, both on-site and off-site via an internet browser, using augmented reality with occlusion handling.

Pediatric hypertension based on Japanese Society of Hypertension Guidelines (JSH 2019) with actual school blood pressure screening data in Japan

Kikuchi Toru 대한소아청소년과학회 2022 Clinical and Experimental Pediatrics (CEP) Vol.65 No.6

Blood pressure (BP) in children and adolescents is associated with their growth. BP is most strongly associated with height during height gain and with degree of obesity after reaching final height. BP in childhood and adolescence is correlated with BP in adulthood. The pathophysiology of pediatric essential hypertension is associated with obesity, excess salt intake, and a low birth weight. The common causes of pediatric secondary hypertension are renal parenchymal and renovascular diseases. The significance of diagnosing pediatric hypertension involves detecting secondary hypertension and preventing organ damage due to hypertension as well as tracking essential hypertension in adulthood. Appropriate BP measurement procedures are required for diagnosing pediatric hypertension. The inflatable bladder of an appropriately sized cuff should exceed 40% of the arm circumference. BP measurements should be performed consecutively at least 3 times using an appropriately sized cuff. The diagnosis of hypertension requires that all BP values measured on 3 or more occasions be above the reference value. The criteria for pediatric hypertension are determined based on the distribution of BP in healthy children and adolescents, with values above the 95th percentile of normal representing hypertension. Japanese criteria define pediatric hypertension as ≥120/70 mmHg for preschool children, ≥130/80 mmHg for 1st–3rd graders, ≥135/80 mmHg for 4th–6th graders, ≥140/85 mmHg for 7th–9th grade boys, ≥135/80 mmHg for 7th–9th grade girls, and ≥140/85 mmHg for senior high school boys and girls. The prevalence of Japanese pediatric hypertension was 0.9% based on proper measurement protocols. The basis of managing pediatric essential hypertension is healthy lifestyle modifications. Pharmacotherapy is indicated for persistent hypertension, symptomatic hypertension, secondary hypertension, the development of target organ damage, the presence of chronic kidney disease, and diabetes mellitus. Screening for pediatric hypertension is important; therefore, BP should be routinely measured in children and adolescents.

A Damage Model for Void Configuration and Failure under Different Constrained Deformation Regions in Ductile Matrix

Kikuchi, M .,Geni, M . 대한금속재료학회(대한금속학회) 2001 METALS AND MATERIALS International Vol.7 No.4

The constraint effects of SiC particle volume fractions and their specimen geometry are analyzed by conducting tensile tests while changing the SiC particle volume fraction 0%, 2% and 10% and the tensile specimen notch radius 0.5, 1.0, 2.0, 4.0, 8.0 and 16.0 ㎜. The effect of constraint on the void configuration and coalescence are investigated experimentally using 3-dimensional SEM fracture surface observations and 3-dimensional image analysis. It was found that the final void volume fraction and void shape were greatly affected by stress triaxiality and deformation constraint.

Design of Seismic Isolated Tall Building with High Aspect-Ratio

Kikuchi, Takeshi,Takeuchi, Toru,Fujimori, Satoru,Wada, Akira Council on Tall Building and Urban Habitat Korea 2014 International journal of high-rise buildings Vol.3 No.1

When seismic isolation system is applied to high aspect-ratio (height/wide-ratio) steel structures, there are several problems to be taken into consideration. One is lifting up tensile force on the isolation bearing by overturning moment caused by earthquake. Another is securing building stiffness to produce seismic isolation effects. Under these conditions, this paper reports the structural design of high-rise research building in the campus of Tokyo Institute of Technology. With the stepping-up system for the corner bearings, the narrow sides of single span framework are designed to concentrate the dead load as counter-weight for the tensile reaction under earthquake. Also we adopted concrete in-filled steel column and Mega-Bracing system covering four layers on north & south framework to secure the horizontal stiffness of the building.

Experimental Study On Seismic Behavior Of Masonry Walls With Column

Kikuchi, Kenji,Park, Kang-Geun 한국공간구조학회 2006 한국공간구조학회지 Vol.6 No.2

본 연구는 보강 조적벽체의 지진거동에 대한 실험적 연구로써, 기둥의 보강, 조적벽체의 보강, 횡하중 높이에 대한 역학적 특성을 분석하였다. 시험체는 구멍이 있는 콘크리트 블록으로 만들었고, 전단 스팬비, 횡하중 높이의 영향, 보강기둥 및 벽체 철근 보강비에 대한 구조적 특성을 파악할 수 있도록 하였다. 벽체의 횡력에 대한 하중점의 벽체 높이의 0.67, 1.08 및 1.1배로 하였다. 수평방향의 철근비는 0, 0.08, 0.18, 수직 방향의 철근비는 0.18, 0.36, 0.64로 하였다. In order to investigate the effect of the height of application point of lateral loads and reinforcing steel bars in walls and columns in improving the seismic behavior of confined concrete block masonry walls, an experimental research program is conducted. A total of twelve one-half scale specimens are tested under repeated lateral loads. Specimens are tested to failure with increasing maximum lateral drifts while a vertical axial load was applied and maintained constant. The specimens adopted are two-dimensional (2D) hollow concrete block masonry walls with different parameters such as shear span ratio, inflection point and percent of reinforcement in confining columns and walls. Test results obtained for each specimen include cracking patterns, load-deflection curve, and strains in reinforcement and walls in critical locations. Analysis of test data showed that above parameters generate a considerable effect on the seismic performance of confined concrete block masonry walls.

Self-Assessment and Working time on Nut Size Distinction Skill of Marine Engineers

KIKUCHI Kazumitsu 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

A rule of thumb for marine engineers is that if a marine engineer has much experience in maintaining machines, the marine engineer can distinguish the size of the tool (spanner or wrench) required for removing machine nuts or bolts by mere observation [1]. This study investigates whether this rule of thumb is related to self-assessment and working time for the distinction of nuts. The participants in this experiment were marine engineering students without practical experience. The experiment included visual and hand conditions. The experiment place was not only a ship engine room but a training room where noise, high temperature, and the smell of fuel oil in the marine engine plant were not experienced by the students. The results showed that the number of the nuts accurately distinguished was unaffected by working hours and self-assessment of the participants who had a boarding history of 12 months on the training ship. Safe operation on marine engine plants must rely on the skills of marine engineers, such as a nut size distinction skill.

Measurement of the Permeability in a Ferrite Core by Superimposing Bias Current

Kikuchi, Kousuke,Kanie, Tomohiko,Takeo, Takashi The Korean Institute of Electrical Engineers 2014 The Journal of International Council on Electrical Vol.4 No.1

In this study, we investigate measurement of the magnetic permeability in a ferrite core at RF frequencies when bias current is superimposed on an RF signal with a view to adaptively controlling performance of RF transformers using ferrite cores. A measurement arrangement used comprises a short microstrip line (MSL) circuit including a coaxial conductor (CC) structure consisting of an electrically grounded metal pipe, a center conductor and a sample between them. A bias tee network is incorporated into this MSL-CC circuit in order to superimpose direct current on an RF signal. Using this arrangement, a dependence of permeability on an amplitude of superimposed bias current was measured at frequencies of 10 MHz to 500 MHz. Reliability of the measurement results is discussed based on several experimental data, implying that the method has an accuracy less than 10 % at most of the above frequencies.