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Huang Lu,Xia Li,Nie Tiejian,Cui Bozhou,Lu Jianjun,Lu Fangfang,Fan Feiyan,Ren Dongni,Lu Yuan,Gao Guodong,Yang Qian 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Traumatic brain injury (TBI) is a major cause of death and disability in adults. The pathological process of TBI involves a multifactorial cascade in which kinases have been proven contribute to interactions between relevant factors and amplification of signaling cascades. Cyclin-dependent kinase 5 (Cdk5) is a promising kinase that has been implicated in various brain disorders, including TBI. However, the mechanism by which Cdk5 induces neuronal damage remains unclear. Here, we show for the first time that Drosha, a key enzyme in microRNA biogenesis, is a pivotal substrate of abnormally activated Cdk5. Cdk5-mediated phosphorylation decreases Drosha expression and exacerbates nerve injury in TBI. We proved that maintaining Drosha expression via the administration of repurposed Cdk5 inhibitors that were previously studied in clinical trials is a promising approach for the early treatment of TBI. Together, our work identifies Drosha as a novel target for neuroprotective strategies after TBI and suggests Cdk5-mediated regulation of Drosha expression as a potential therapeutic strategy for early TBI intervention.
Design of stepwise foam claddings subjected to air-blast based on Voronoi model
Minzu Liang,Fangyun Lu,Guodong Zhang,Xiangyu Li 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.23 No.1
Design of stepwise foam claddings subjected to air-blast is performed based on random Voronoialgorithm. FE models are constructed using the random Voronoialgorithm, and numerical analysis is carried out to simulate deformation mode and energy absorption of the cladding by the ABAQUS/Explicit software. The FE model is validated by test result, and good agreement is achieved. The deformation patterns are presented to give an insight into the influences of distribution on deformation mechanisms. The energy absorbed by the stepwise foam cladding is examined, and the parameter effects, including layer number, gradient, and blast loading, are discussed. Results indicate that the energy absorption capacity increases with the number of layer, gradient degree, and blast pressure increasing.
JunSong Qin,Yan Lu,Dongxiao Niu,Guodong Zhu 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.8
The medium and long term load forecasting is the basis of power planning, investment, production, scheduling and trade, which plays an important role in electric power safety and economic operation. In China, it has the increasing uncertainty and the uncertainty of random variation to forecast the medium and long term load. Thus we can regard it as a typical grey system. However, the traditional grey prediction method cannot be adapt to the needs of the load forecasting gradually. It need to be rich and perfect with the continuous improvement of power system complexity and power marketization degree. This paper studied the modelling mechanism of grey prediction model. Then we analyzed the problems existing in the model, including the boundary value problem, the background value structure problem and the least squares parameter identification problem. This paper put forward an optimization method to directly identify the boundary value x(0)(1), the developing coefficient a and grey coefficient b using ant colony algorithm according to the time response expression of GM(1,1) model, so that it established an optimized GM(1,1) prediction model based on ant colony algorithm. This model can fix the impact of boundary value, and also avoid the errors brought by the background value construction and the least squares parameter estimation. It can verify the effectiveness of the proposed optimization model through the load data simulation. And it can improve the prediction accuracy effectively.
Liping Wei,Youjun Lu,Jianbo Zhu,Guodong Jiang,Jun Hu,Haipeng Teng 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.10
The effect of cohesive particles on the pressure fluctuations was experimentally investigated in a binary gassolid fluidized bed. The pressure fluctuation signals were measured by differential pressure sensors under conditions of various weight percentages of cohesive particles. The cohesive particles increased the fixed bed pressure drop per unit height and decreased the minimum fluidization velocity. The Wen & Yu equation well predicts the minimum fluidization velocity of the binary system. The addition of cohesive particles slightly decreased the bubble size in bubbling flow regime when the cohesive particles and the coarse particles mixed well, while the bubble size greatly decreased when the cohesive particles agglomerated on the bed surface. The time series of pressure fluctuations was analyzed by using the methods of time domain, frequency domain and wavelet transformation. The normalized standard deviation of pressure fluctuations decreased with increasing weight percentages of cohesive particles. A wide bandwidth frequency of 0 to 1Hz got narrower with a single peak around 0.6Hz with an increase in proportion of the cohesive particles. The meso-energy and micro-energy of pressure fluctuations were decreasing with increasing cohesive particles proportions, which indicated that adding cohesive particles could reduce the energy dissipation of bubble and particle fluctuations.
Application of the French Codes to the Pressurized Thermal Shocks Assessment
Mingya Chen,Guian Qian,Jinhua Shi,Rongshan Wang,Weiwei Yu,Feng Lu,Guodong Zhang,Fei Xue,Zhilin Chen 한국원자력학회 2016 Nuclear Engineering and Technology Vol.48 No.6
The integrity of a reactor pressure vessel (RPV) related to pressurized thermal shocks (PTSs)has been extensively studied. This paper introduces an integrity assessment of an RPVsubjected to a PTS transient based on the French codes. In the USA, the “screening criterion”for maximum allowable embrittlement of RPV material is developed based on theprobabilistic fracture mechanics. However, in the French RCC-M and RSE-M codes, whichare developed based on the deterministic fracture mechanics, there is no “screening criterion”. In this paper, the methodology in the RCC-M and RSE-M codes, which are used forPTS analysis, are firstly discussed. The bases of the French codes are compared with ASMEand FAVOR codes. A case study is also presented. The results show that the method in theRCC-M code that accounts for the influence of cladding on the stress intensity factor (SIF)may be nonconservative. The SIF almost doubles if the weld residual stress is considered. The approaches included in the codes differ in many aspects, which may result in significantdifferences in the assessment results. Therefore, homogenization of the codes inthe long time operation of nuclear power plants is needed.
RETURN CONTROL OF ELECTRONIC POWER STEERING UNEQUIPPED WITH AN ANGLE SEN
Shaosong Li,Luping Guo,Gaojian Cui,Zhixin Yu,Xiaohui Lu,Guodong Wang 한국자동차공학회 2019 International journal of automotive technology Vol.20 No.2
A steering wheel may not be able to return to the center position due to friction torque in its mechanism. Thus, in this study, a return controller is developed to improve the returnability of an electric power steering vehicle without an angle sensor. The aligning moment is well estimated on the basis of a Kalman filter estimator. A trigger rule is also proposed to switch between assist and return controls. Finally, the compensation current for the return control is regulated in accordance with the aligning moment and vehicle speeds. Simulation and real vehicle results show that the proposed control system can significantly improve the returnability of the steering system.
Lusha Ji,Cheng-Chao Zheng,Rui Xu,Longtao Lu,Jiedao Zhang,Guodong Yang,Jinguang Huang,Changai Wu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.2
Nuclear matrix attachment regions (MARs) regulate the higher-order organization of chromatin and affect the expression of their flanking genes. In this study, a tobacco MAR, TM6, was isolated and demonstrated to remarkably increase the expression of four different promoters that drive gusA gene and adjacent nptII gene. In turn, this expression enhanced the transformation frequency of transgenic tobacco. Deletion analysis of topoisomerase II-binding site, AT-rich element, and MAR recognition signature (MRS) showed that MRS has the highest contribution (61.7%) to the TM6 sequence-mediated transcription activation. Micrococcal nuclease (MNase) accessibility assay showed that 35S and NOS promoter regions with TM6 are more sensitive than those without TM6. The analysis also revealed that TM6 reduces promoter DNA methylation which can affect the gusA expression. In addition, two to-bacco chromatin-associated proteins, NtMBP1 and NtHMGB, isolated using a yeast one-hybrid system, specifically bound to the TM6II-1 region (761 bp to 870 bp) and to the MRS element in the TM6II-2 (934 bp to 1,021 bp) region, respectively. We thus suggested that TM6 mediated its chromatin opening and chromatin accessibility of its flanking promoters with consequent enhancement of transcription.