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Cerulein 유도 급성췌장염에서의 활성산소라다칼의 역할
김정원,임창영,이명인,이종화,조정희,송일한,김정택,박동국,노임환,양미라,손소희,진영주 대한소화기학회 1997 대한소화기학회지 Vol.30 No.6
Backgroung/Aims: Oxygen radicals are suggested to be an imponant role in the pathogenesis of acute pancreatitis in experimental animals. Cerulein is closely related to the cholecystokinin and it is a potent stimulant of pancreatic exocrine secretion. The purpose of this study was to evaluate the effect of free oxygen radicals in the cerulein induced acute pancreatitis. Methods: Two groups of male Sprague Dawley rats weighing 380-420gm were studied: control group(n=12), fasted for 12 hours the animals with intraperitoneal injection twice of 0,9% saline with a l-hour interval, and cerulein group(n=20), animals who fasted for 12 hour received two intraperitoneal injections of cerulein at hourly intervals(40 microgram/kg). After 4 hours of observation time, serum-amylase and the tissue content of malondialdehyde, glutathione and histology was studied. Results: Serum amylase in the cerulein group was significantly high(p$lt;0.001), compared with the control group. Also glutathione level of pancreatic tissue was decreased significantly(p$lt;0.01) and pancreatic malondialdehyde level was increased significantly(p$lt;0.01) in the cerulein treated group. In pancreatic histology, pancreatic ederna including acinar cell atrophy, periductal intlammation, and periductal fibrosis were observed in all cases of cerulein treated group. Conclusions: We concluded that the profound depletion of the activity of glutathione and increase of malondialdehyde occuring after cerulein induced pancreatitis seemed to be important in tissue injury and oxygen radicals might be responsible for an important step in the initation of acute pancreatitis.