Three-dimensional Adaptive Sliding Mode Guidance Law for Missile with Autopilot Lag and Actuator Fault

Guiying Li,Zhigang Yu,Zhongxian Wang 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.6

This paper investigates guidance scheme for missile with actuator failure and dynamics of autopilot. Firstly, considering first-order dynamics of autopilot, the guidance model with actuator failure is established. Secondly, an adaptive sliding mode fault-tolerant guidance law is designed on the basis of passive fault-tolerant technique and a novel nonsingular fast terminal sliding mode (NFTSM) manifold. Then, the adaptive algorithm with the feature of low-pass filter is proposed to ensure that adaptive parameters are bounded when the sliding mode is non-ideal. Finally, Lyapunov stability theory is adopted to prove that the states of closed-loop system are practical finite-time stability. Simulation results demonstrate the effectiveness and robustness of the proposed guidance strategy under the certain actuator failure.

Separation of Macrophages Using a Dielectrophoresis-Based Microfluidic Device

Ying Zhang,Shangyu Wang,Jie Chen,Fang Yang,Guiying Li 한국바이오칩학회 2020 BioChip Journal Vol.14 No.2

Macrophages are an important component of the immune system and play a key role in tissue damage repair and immune defense. As a potential biomarker, macrophages contribute to the early diagnosis and therapy of cancer and other disease. The isolation of macrophages is a key step in relevant research and clinical applications. However, conventional macrophage separation and purification methods rely on benchtop equipment and are time-consuming, inefficient, complicated, and immobile. Herein, we present a method based on dielectrophoresis (DEP) to rapidly separate and purify macrophages from micro-volume samples using a microfluidic device for liquid biopsy and point-of-care testing (POCT). The device can be mechanically manipulated easily for straightforward separation. The DEP force on macrophages was measured under different electric field conditions, then the macrophages were successfully separated from the mixture of macrophages (RAW264.7) and breast cancer cells (MCF-7) using the microfluidic chip. The purity of macrophages in the collections reached higher than 99%. The effects of flow rate and voltage on the separation efficiency of macrophages by DEP were further studied to optimize the separation conditions. This work proposes a new method for rapid separation of macrophages based on microfluidic systems, providing a technical foundation for macrophage-based disease monitoring and real-time rapid diagnosis.

Enhanced photocatalytic mechanism of Ag₃PO₄ nano-sheets using MS₂ (M = Mo, W)/rGO hybrids as co-catalysts for 4-nitrophenol degradation in water

Zhang, Weiping,Li, Guiying,Wang, Wanjun,Qin, Yaxin,An, Taicheng,Xiao, Xinyan,Choi, Wonyong Elsevier 2018 Applied Catalysis B Vol.232 No.-

<P><B>Abstract</B></P> <P>A chemically modified Ag<SUB>3</SUB>PO<SUB>4</SUB>@MS<SUB>2</SUB>(M = Mo, W)/rGO composite was firstly synthesized via a liquid-exfoliation solvothermal method. The structure, morphology, optical properties and composition were characterized by X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, UV–vis diffuse reflectance spectra and X-ray photoelectron spectroscopy, respectively. The characterization results indicated that compact structure could be obtained by using this typical method due to in-situ chemical modification, which could also control the sizes of Ag<SUB>3</SUB>PO<SUB>4</SUB> nano-sheets by adding MS<SUB>2</SUB>/rGO hybrids. More importantly, the resultant Ag<SUB>3</SUB>PO<SUB>4</SUB>@MS<SUB>2</SUB>/rGO composite exhibited higher photocatalytic activity and stability toward the degradation of 4-nitrophenol than pure Ag<SUB>3</SUB>PO<SUB>4</SUB> under sunlight irradiation. The stable structure of Ag<SUB>3</SUB>PO<SUB>4</SUB>@MS<SUB>2</SUB>/rGO was closely related with Z-scheme electronic structure and electrical conductivity of MS<SUB>2</SUB>/rGO hybrids, leading to a higher consumption and transfer of photogenerated electrons. However, by controlling the amounts of MS<SUB>2</SUB>/rGO hybrids, more stable but lower photocatalytic activity composites could be obtained. Further analysis found that the holes and O<SUB>2</SUB> <SUP>−</SUP> were the main reactive species involved in the photocatalytic degradation of 4-nitrophenol. In addition, possible photocatalytic degradation pathways of 4-nitrophenol were also proposed based on the identified intermediates. The findings of this work may provide a new method to design efficient composites for photocatalytic degradation of organic pollutants.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ag<SUB>3</SUB>PO<SUB>4</SUB>@MS<SUB>2</SUB>/rGO catalyst was fabricated via a liquid-exfoliation solvothermal method. </LI> <LI> Ag<SUB>3</SUB>PO<SUB>4</SUB>@MS<SUB>2</SUB>/rGO has high photocatalytic activity and stability under sunlight. </LI> <LI> The stability of Ag<SUB>3</SUB>PO<SUB>4</SUB>@MS<SUB>2</SUB>/rGO was due to its rapid transfer of photogenerated e<SUP>−</SUP>. </LI> <LI> h<SUP>+</SUP> and O<SUB>2</SUB> <SUP>−</SUP> were the main RSs in photocatalytic degradation of 4-nitrophenol. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Interference of periostin attenuates pathological changes, proinflammatory markers and renal fibrosis in diabetic kidney injury

Duan Xiaoting,Chen Cheng,Liu Xiaoli,Wang Taoxia,Feng Shuning,Li Jianwei,Li Guiying 한국유전학회 2023 Genes & Genomics Vol.45 No.11

Background Diabetic nephropathy (DN) is a prevalent complication of diabetes, in which inflammation and fibrosis are the significant pathogenesis. Periostin is a matricellular protein that functions on stabilizing the extracellular matrix by binding to integrins during development. This study aimed to explored the role of periostin in DN. Methods The animal and cell models of DN were constructed in streptozocin (STZ)-induced mice and high glucose-challenged human mesangial cells (HMCs). The role of periostin in pathological changes, inflammation and fibrosis in DN was investigated through biochemical detection, HE and Masson staining and scores, western blot, enzyme‑linked immunosorbent assay (ELISA) and real-time quantitative PCR (RT-qPCR) assays. Results Knockdown of periostin counteracted the STZ-induced the ratio of kidney weight and body weight, and the concentrations of urine albumin excretion (UAE), serum creatinine (Scr), urine albumin/creatinine ratio (UACR) and blood urea nitrogen (BUN) in mice. Moreover, silencing of periostin alleviated the pathological manifestations and reduced the concentrations of IL-6, TNF-α and IL-1β in mice kidney tissues and sera. Also, downregulation of periostin decreased the relative protein expression of fibronectin, collagen IV and α-SMA in kidney tissues. Meanwhile, interference of periostin attenuated the levels of pro-inflammation factors and the expressions of fibrosis markers in HG-induced HMCs. Conclusion Interference of periostin resisted DN via attenuating the pro-inflammatory cytokines release and renal fibrosis in diabetic kidney injury. Our study establishes a basis for its further study and underlying application in clinical practice in diagnosing and treating diabetic kidney injury or other relevant diseases.

Comparison of the Fatty Acid Composition and Small Molecular Metabolites between Yanjin Blackbone Chicken and Piao Chicken Meat

Rong Jia,Wen Xun,Guozhou Liao,Yuan Yang,Guiying Wang 한국축산식품학회 2023 한국축산식품학회지 Vol.43 No.6

The fatty acid composition and small molecular metabolites in breast and leg meat of Yanjin blackbone chickens (YBC) and Piao chickens (PC) were detected by gas chromatography-mass spectrometry and liquid chromatography-quadrupole static field orbital trap mass spectrometry. Thirty-two fatty acids were detected, and the total fatty acid content of PC was significantly higher than that of YBC (p<0.05). Oleic acid, linoleic acid, palmitic acid, stearic acid, and arachidonic acid were the main fatty acids in the two chicken varieties, and the composition of fatty acids in the two varieties were mainly unsaturated fatty acids, being more than 61.10% of the total fatty acids. Meanwhile, 12 and 16 compounds were screened out from chicken legs and chicken breasts of YBC and PC, respectively, which had important contributions to the differences between groups.