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용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1
To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.
Development of Non-restriction/Non-consciousness Oriented U-Health System
Jung-Soo Han,Kang-hyun Lee,Gui-Jung Kim 한국콘텐츠학회 2009 ICCC International Digital Design Invitation Exhib Vol.2009 No.12
This study aims to develop a mobile-based portable u-Health Monitoring System which provides a personal medical service on demand by processing patients' data intellectually achieved through sensing technique of non-restriction/non-consciousness oriented and deciding. To do this, it tries to develop a non-restriction /non-consciousness oriented sensing technique which is related to glycosuria and cardiovascular diseases. Also, we composed a USN-based portable monitoring unit.
한정수(Jung-Soo Han),김귀정(Gui-Jung Kim) 한국콘텐츠학회 2011 한국콘텐츠학회논문지 Vol.11 No.7
본 논문은 건축자재들을 컴포넌트와 패턴으로 조립하여 패턴 단위로 건축설계가 효율적으로 이루어질 수 있도록 하는 스틸하우스 설계 인터페이스를 개발한다. 또한 이 기술을 이용하여 건축의 공정에 설계, 분석, 변경정보, 조립 등의 건축설계를 시뮬레이션을 통하여 건축의 손쉬운 변경과 비용을 효과적으로 절감하기 위한 기술을 지원하는 조립 건축설계 시스템 개발을 목적으로 한다. 특히 설계자와 사용자도 패턴을 이용하여 쉽게 건축물을 변경시킬 수 있으며 변경에 따라 필요한 자재들의 패턴 정보와 변경된 건축물의 설계도가 자동 생성된다. 또한 개인의 숙련도나 지식 가시화를 통해 발생할 수 있는 지식검색 역시 구현 목표로 한다. This paper develops the steel-house design interface that helps make building design effectively done by constructing building materials as components and assembling them as patterns. It also aims to develop the Flexible Building Design System that supports a technology which makes change of constructing easy and reduces the cost effectively through a simulationof building design like design, analysis, change information, etc., by grafting the virtual building technology into the process of building. It especially is possible for a designer and user to change a building easily by using patterns and according to the change, pattern information of materials needed and the plans of the building are made automatically. Kin-search that can be happened through personal proficiency or knowledge visualization is also the reason why the technology should be embodied.
한정수(Han Jung-Soo),김귀정(Kim Gui-Jung) 한국콘텐츠학회 2003 한국콘텐츠학회 종합학술대회 논문집 Vol.1 No.2
본 연구는 기존의 유사 부품 검색 알고리즘인 spreading activation 방법의 단점인 속도의 문제를 해결하여 보다 효율적인 부품 검색을 할 수 있도록 개선시켰다. 또한 개선된 SARM을 이용한 부품 정보와 질의어 관련 인터페이스를 구축하였고 이를 통한 부품 검색 시스템을 구축하였다. This paper enhanced similar components retrieval algorithm-spreading activation method. The solution is that retrieval speed is overcome and more efficiently components are retrieved. Also we implemented interface for component information and query, and constructed component retrieval system.