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Xu, Guang-Ri,Qi, Xin-hua,Yang, Fengxia,Lee, Jae-Joon,Xu, Ming-Lu,Zhang, Yu-Ping,Kim, Sunghyun WILEY-VCH Verlag 2009 Electroanalysis Vol.21 No.22
<P>A glassy carbon electrode having two polymer layers has been applied to selectively detect epinephrine. The inner layer formed by electropolymerization of macrocyclic nickel complex functioned as an electrocatalyst for epinephrine oxidation and the outer layer composed of hydrolyzed polyurethane γ-benzyl L-glutamate as a screening layer. Differential pulse voltammetry showed almost 100% recovery of epinephrine even in 100-fold excess of interferents. When applied to a dual glassy carbon electrode as an amperometric detector in flow injection analysis, a linear response over 0.1 μM and 10 μM was obtained. Recovery tested for 5-fold diluted human urine samples was 97.5%.</P>
rs10505474 and rs7837328 at 8q24 Cumulatively Confer Risk of Prostate Cancer in Northern Han Chinese
Zhang, Lin-Lin,Sun, Liang,Zhu, Xiao-Quan,Xu, Yong,Yang, Kuo,Yang, Fan,Yang, Yi-Ge,Chen, Guo-Qiang,Fu, Ji-Cheng,Zheng, Chen-Guang,Li, Ying,Mu, Xiao-Qiu,Shi, Xiao-Hong,Zhao, Fan,Wang, Fei,Yang, Ze,Wang, Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Aims: Genome-wide association studies (GWAS) have identified several risk variants for prostate cancer (pCa) mainly in Europeans, which need to be further verified in other racial groups. We selected six previously identified variants as candidates and to define the association with PCa in Northern Han Chinese. Methods: 749 subjects from Beijing and Tianjin in Northern China were included. Six variants (rs10505474, rs7837328, rs4242384, rs7813, rs486907 and rs1058205) were genotyped by high resolution melting (HRM) assays. The individual and cumulative contribution for of the risk of PCa and clinical covariates were analyzed. Results: Among the six candidate variants, onlyrs10505474, and rs7837328, both locating at 8q24 region, were associated with PCa in our population.rs10505474 (A) was associated with PCa ($OR_{recessive}=1.56$, p=0.006); and rs7837328 (A) was associated with PCa ($OR_{dominant}=1.38$, p=0.042/$OR_{recessive}=1.99$, p=0.003). Moreover, we observed a cumulative effects between them ($p_{trend}=2.58{\times}10^{-5}$). The joint population attributable risk showed the two variants might account for 71.85% of PCa risk. In addition, we found the homozygotes of rs10505474 (A) and rs7837328 (A) were associated with PCa clinical covariants (age at onset, tumor stage, respectively) ($p_{age}=0.046$, $P_{tumorstage}=0.048$). Conclusion: rs10505474 (A) and rs7387328 (A) at 8q24 are associated with PCa and cumulatively confer risk, suggesting the two variations could determine susceptibility to PCa in the Northern Chinese Han population.
Yang Guang,Li Jiajing,Xu Qian,Xie Huilan,Wang Lijun,Zhang Minhao 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.4
Background Bone cancer pain (BCP) severely compromises the life quality of patients with advanced cancer or bone metastases . Objective This study investigates the analgesic effect of sodium aescinate (SA) on BCP, and the underlying mechanisms within the spinal cord (SC) and dorsal root ganglion (DRG). Walker 256 cells were intratibially inoculated into rats to establish a BCP model. 10, 20, and 40 g/L of SA was intrathecally injected, respectively, and then, hyperalgesia and allodynia were evaluated by measuring the paw withdrawal threshold (PWT) and paw withdrawal latency (PWL). The effect of SA on neuroinflammation was observed by detecting the production of the pro-inflammatory cytokines based on RT-qPCR and ELISA. The NF-κB and p38 MAPK/c-Fos signaling was detected by WB analysis. Furthermore, RT-qPCR and WB analyses of Iba-1and CD206 were performed to assess microglial activation. Result The development of hyperalgesia and allodynia, and an increase of pro-inflammatory cytokines production, as well as microglial activation, were observed in the BCP rats. SA (40 g/L) not only relieved the pain-related behaviors induced by BCP but also suppressed the release of pro-inflammatory cytokines and the activation of microglia in the SC and DRG. SA could also inhibit p38 MAPK/c-Fos signaling in both the SC and DRG, which might contribute to the suppression of microglial activation. Conclusion Our findings suggest that SA plays a promising analgesic role in the BCP rats by suppressing infl ammation and microglial activation, and these effects may be associated with the suppression of p38 MAPK/c-Fos signaling.
Collaborative Sub-channel Allocation with Power Control in Small Cell Networks
( Guang Yang ),( Yewen Cao ),( Deqiang Wang ),( Jian Xu ),( Changlei Wu ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.2
For enhancing the coverage of wireless networks and increasing the spectrum efficiency, small cell networks (SCNs) are considered to be one of the most prospective schemes. Most of the existing literature on resource allocation among non-cooperative small cell base stations (SBSs) has widely drawn close attention and there are only a small number of the cooperative ideas in SCNs. Based on the motivation, we further investigate the cooperative approach, which is formulated as a coalition formation game with power control algorithm (CFG-PC). First, we formulate the downlink sub-channel resource allocation problem in an SCN as a coalition formation game. Pareto order and utilitarian order are applied to form coalitions respectively. Second, to achieve more availability and efficiency power assignment, we expand and solve the power control using particle swarm optimization (PSO). Finally, with our proposed algorithm, each SBS can cooperatively work and eventually converge to a stable SBS partition. As far as the transmit rate of per SBS and the system rate are concerned respectively, simulation results indicate that our proposed CFG-PC has a significant advantage, relative to a classical coalition formation algorithm and the non-cooperative case.
Study on rectangular concrete-filled steel tubes with unequal wall thickness
Yang Zhang,Chen-Jiang Yu,Guang-Yuan Fu,Bing Chen,She-Xu Zhao,Si-Ping Li 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.22 No.5
Rectangular concrete-filled steel tubular columns with unequal wall thickness were investigated in the paper. The physical centroid, the centroidal principal axes of inertia, and the section core were given. The generalized bending formula and the generalized eccentric compression formula were deduced, and the equation of the neutral axis was also provided. The two rectangular concrete-filled steel tubular stub specimens subjected to the compression load on the physical centroid and the geometric centroid respectively were tested to verify the theoretical formulas.
Fan, Guang-Hua,Wang, Zhong-Ming,Yang, Xi,Xu, Li-Ping,Qin, Qin,Zhang, Chi,Ma, Jian-Xin,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Resveratrol has been examined in several model systems for potential effects against cancer. Adenosine monophosphate-activated protein kinase (AMPK) is reported to suppress proliferation in most eukaryocyte cells. Whether resveratrol via AMPK inhibits proliferation of oesophageal adenocarcinoma cells (OAC) is unknown. The aim of this study was to determine the roles of AMPK in the protective effects of resveratrol in OAC proliferation and to elucidate the underlying mechanisms. Treatment of cultured OAC derived from human subjects or cell lines with resveratrol resulted in decreased cell proliferation. Further, inhibition of AMPK by pharmacological reagent or genetical approach abolished resveratrol-suppressed OAC proliferation, reduced the level of $p27^{Kip1}$, a cyclin-dependent kinase inhibitor, and increased the levels of S-phase kinase-associated protein 2 (Skp2) of $p27^{Kip1}$-E3 ubiquitin ligase and 26S proteasome activity reduced by resveratrol. Furthermore, gene silencing of $p27^{Kip1}$ reversed resveratrol-suppressed OAC proliferation. In conclusion, these findings indicate that resveratrol inhibits Skp2-mediated ubiquitylation and 26S proteasome-dependent degradation of $p27^{Kip1}$ via AMPK activation to suppress OAC proliferation.
Jian Xu,Yewen Cao,Deqiang Wang,Changlei Wu,Guang Yang 한국전자통신연구원 2016 ETRI Journal Vol.38 No.3
Recently, a product-matrix (PM) framework was proposed to construct optimal regenerating codes for homogeneous distributed storage systems (DSSs). In this paper, we propose an extended PM (EPM) framework for coding of heterogeneous DSSs having different repair bandwidths but identical storage capacities. Based on the EPM framework, an explicit construction of minimum remote-repair bandwidth regenerating (MRBR) codes is presented for a specific heterogeneous DSS, where two geographically different datacenters with associated storage nodes are deployed. The data reconstruction and regeneration properties of the MRBR code are proved strictly. For the purpose of demonstration, an example implementation of MRBR code is provided. The presented MRBR code is the first optimal strict-regenerating code for heterogeneous DSSs. In addition, our proposed EPM framework can be applied to homogeneous systems also.
Effect of synthesis conditions on the particle size and morphology of YAG powder
Jie-Guang Song,Fang Wang,Ming-Han Xu,Yin-Yan Ju,Yang-Liang Li,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.2
Yttrium aluminum garnet (YAG) is currently a widely applied structural and functional material. To prepare highperformance YAG ceramics we prepared pure YAG powder, after calcining the precursor at 1100 ºC, by co-precipitation with ammonia as the precipitant and aluminum nitrate as well as yttrium nitrate as raw materials. The preparation conditions for the YAG precursor were a pH of 9, a titration rate of 10 ml/ minute and a reaction time of 60 minutes. The mean paricle size of the YAG powder was 11ìm. The mean particle size for the YAG powder increased with an increase in the pH and at a higher pH the YAG particles were more irregular in shape. The mean particle size and particle size distribution range of the YAG powder increased with an increase in the titration rate. For the YAG powder with a higher mean particle size, the particle size distribution range was wider but the size of most YAG particles was still small and the YAG particles were nearly spherical.
Regional Landslide Susceptibility Assessment Based on Combined Model with Certainty Factor Method
( Peihua Xu ),( Guang Yang ),( Chen Cao ),( Wen Zhang ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
This paper takes the case of Diexi Township to Shidaguan Township, Maoxian County, Sichuan Province as the research area. According to the field data and the basic conditions of the study area, 10 impact factors such as the slope, slope direction, section curvature, elevation, undulation, stratum, distance from the river, distance from the fault, land type and vegetation coverage are selected. Using GIS technology as the operating platform, three methods, i.e., deterministic coefficient + analytic hierarchy process (CF-AHP), deterministic coefficient + logistic regression method (CF-LR) and deterministic coefficient + multi-layer perceptron method of neural network (CF-MLP), were used to evaluate the sensitivity of landslide hazard in the study area. The landslide hazard in this area was divided into four categories: extremely low, low, medium and high sensitive areas, and the effect of the model was tested by receiver operating characteristic curve (ROC). The under-line area (AUC) of the ROC curves of the CF-AHP, CF-LR and CF-MLP combined models were 0.850, 0.884 and 0.867, respectively. The CF-LR combination model worked best. In the CF-LR combination model, the areas of high sensitive area, medium sensitive area, low sensitive area and extremely low sensitive area accounted for 11.3%, 25.1%, 22.5% and 41.1% of the total area, respectively. The results show that the high sensitive area is mainly concentrated around the main water system and the concentrated area of the fault. The results are close to the actual situation and play an important role in the geological disaster risk assessment.