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Patrick Mountapmbeme Kouotou,Guan-Fu Pan,Jun-Jie Wenga,Shi-Bin Fan,Zhen-Yu Tian 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.35 No.-
The effective evaluation of the catalytic performance of Co3O4 supported on an inert carrier wasinvestigated toward the deep oxidation of light olefins. Thin Co3O4 films were deposited on grid mesh ofstainless steel using one-step chemical vapor deposition method. The as-deposited materials werecharacterized in terms of structure, morphology and composition. Co3O4 crystals with cubic spinelstructures composed of Co2+, Co3+ and nucleophilic oxygen species (O2 ) were obtained. The catalyticresults indicated that Co3O4 supported on steel mesh was highly active to enable the completeconversion of C3H6 and n-C4H8 with a Mars-van Krevelen type mechanism.
Yang Sheng,Xie JiaJun,Pan ZhiJie,Guan HongMei,Tu YueSheng,Ye YuanJian,Huang ShouBin,Fu ShiQiang,Li KangXian,Huang ZhiWei,Li XiaoQi,Shi ZhanJun,Li Le,Zhang Yang 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
The meniscus is vital for maintaining knee homeostasis and function. Meniscal calcification is one of the earliest radiological indicators of knee osteoarthritis (KOA), and meniscal calcification is associated with alterations in biomechanical properties. Meniscal calcification originates from a biochemical process similar to vascular calcification. Advanced glycation end products (AGEs) and their receptors (RAGEs) reportedly play critical roles in vascular calcification. Herein, we investigated whether targeting AGE-RAGE is a potential treatment for meniscal calcification. In our study, we demonstrated that AGE-RAGE promotes the osteogenesis of meniscal cells and exacerbates meniscal calcification. Mechanistically, AGE-RAGE activates mTOR and simultaneously promotes ATF4 accumulation, thereby facilitating the ATF4-mTOR positive feedback loop that enhances the osteogenic capacity of meniscal cells. In this regard, mTOR inhibits ATF4 degradation by reducing its ubiquitination, while ATF4 activates mTOR by increasing arginine uptake. Our findings substantiate the unique role of AGE-RAGE in the meniscus and reveal the role of the ATF4-mTOR positive feedback loop during the osteogenesis of meniscal cells; these results provide potential therapeutic targets for KOA.