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RISS 인기검색어
- 검색키워드
- 저자 : Gu Mingzhou (검색결과 2 건)
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Gu, Yiren,Zhou, Rui,Jin, Long,Tao, Xuan,Zhong, Zhijun,Yang, Xuemei,Liang, Yan,Yang, Yuekui,Wang, Yan,Chen, Xiaohui,Gong, Jianjun,He, Zhiping,Li, Mingzhou,Lv, Xuebin Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.5
Objective: We investigated the temporal expression profiles of long noncoding RNA (lncRNA) and mRNA in the peripheral blood of pigs during development and identified the lncRNAs that are related to the blood-based immune system. Methods: Peripheral blood samples were obtained from the pigs at 0, 7, 28, and 180 days and 2 years of age. RNA sequencing was performed to survey the lncRNA and mRNA transcriptomes in the samples. Short time-series expression miner (STEM) was used to show temporal expression patterns in the mRNAs and lncRNAs. Gene ontology and Kyoto encyclopedia of genes and genomes analyses were performed to assess the genes' biological relevance. To predict the functions of the identified lncRNAs, we extracted mRNAs that were nearby loci and highly correlated with the lncRNAs. Results: In total of 5,946 lncRNA and 12,354 mRNA transcripts were identified among the samples. STEM showed that most lncRNAs and mRNAs had similar temporal expression patterns during development, indicating the expressional correlation and functional relatedness between them. The five stages were divided into two classes: the suckling period and the late developmental stage. Most genes were expressed at low level during the suckling period, but at higher level during the late stages. Expression of several T-cell-related genes increased continuously during the suckling period, indicating that these genes are crucial for establishing the adaptive immune system in piglets at this stage. Notably, lncRNA TCONS-00086451 may promote blood-based immune system development by upregulating nuclear factor of activated T-cells cytoplasmic 2 expression. Conclusion: This study provides a catalog of porcine peripheral blood-related lncRNAs and mRNAs and reveals the characteristics and temporal expression profiles of these lncRNAs and mRNAs during peripheral blood development from the newborn to adult stages in pigs.
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Chi Xiangyu,Li Shengjie,Gu Mingzhou,Li Yaru,Zhu Xixi,Wang Naihua 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.8
The fluid retention effect of the Volume Control Tank (VCT) leads to a long time delay in Reactor Coolant System (RCS) concentration during the boration process. A coupled model combining a lumpedparameter sub-model and a computational fluid dynamics sub-model is currently used to investigate the concentration dynamic characteristic of RCS during the boration process. This model is validated by comparison with experimental data, and the predicted results show excellent agreement with experimental data. We provide detailed fields in VCT and concentration variations of RCS to study the interaction between mixing in VCT and the transient responses of RCS. Moreover, the impacts of the inlet flow rate, inlet nozzle diameter, original concentration, and replenishing temperature of VCT on the RCS concentration characteristic are studied. The inlet flow rate and nozzle diameter of VCT remarkably affect the RCS concentration characteristic. Too-large or too-small inlet flow rates and nozzle diameters will lead to unacceptable long delays. In this work, the optimal inlet flow rate and nozzle diameter of VCT are 5 m3 /h and 58.8 mm, respectively. Besides, the impacts of the original concentration and replenishing temperature of VCT are negligible under normal operating conditions.
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