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토양분야 환경오염공정시험기준과 KS ISO규격의 일원화에 관한 연구
김지인 ( Ji In Kim ),김보경 ( Bo Kyong Kim ),김정화 ( Joung Hwa Kim ),이군택 ( Goon Teak Lee ),이상욱 ( Sang Uk Lee ),안문성 ( Mun Seong Ahn ),임태숙 ( Tae Sook Lim ),한진석 ( Jin Seok Han ),이원석 ( Won Seok Lee ) 한국환경분석학회 2012 환경분석과 독성보건 Vol.15 No.3
Korea has two type of the environmental official test methods, environmental standards enacted by ministry of environment (ES) and Korean industrial standard enacted by ministry of knowledge and Economy (KS), which causes the confusion of users, The main purpose of this study is to compare ES with KS and to make solutions to unify two types of standards. futhermore, We found the ways to improve ES and KS considering many countries aligned domestic standards with international standards. ES for soil quality consisted of sixty official test methods. We focused on thirty official test methods in ES except for the introduction, sampling methods and leak test methods and compared them with the corresponding KS just translated from ISO standard without any technical changes. By reviews and comparative tests between ES and KS we classified them into “No corresponding standards”, “Pre-unification completed”, “Pre-unification impossible”, “Unification completed” and “Unification impossible”. There were eighteen standards possible to unify, six standards impossible to unify and six standards corresponding no KS. We suggested that ESs for CN, phenols and Cr6+ were needed to adopt parts of the procedures in KS for improving recoveries and reducing the pre-treatment time and labor. We also found that both standards had to include detailed information about wavelength to analyze metals for user`s convenience.
국정훈(Kook Joung-Hun),김대군(Kim Dae-Goon),김재수(Kim Jae-Soo) 대한건축학회 2007 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.27 No.1
Waterpower Generation is the pollution-free clean energy that produces electric power using water pressure, and on account of its merit that contributes to supply the superior quality of electricity, its regular construction had been promoted together with the Five-year Plan for Economic Development in 1960s. However, since the Noise which was made during the operation time of the hydraulic turbine dynamo should be inevitably exposed directly to the adjacent office, it brings many inconveniences to the business, and because the dynamo room locating between the hydraulic turbine dynamo and the office was architecturally concluded with the reflection material-centered, it functions rather to amplify the Noise that occurs during the operation time of the hydraulic turbine dynamo. Therefore, this Study has actually surveyed also evaluated the architectural acoustic characteristics of the hydraulic turbine dynamo room on the subject of Daechung Dam. It is now considering that such material could be utilized as the valuable data hereafter in control the Noise of the hydraulic turbine dynamo room.
Park, Hye Ji,Lee, Seong Ho,Son, Dong Ju,Oh, Ki Wan,Kim, Ki Hyun,Song, Ho Sueb,Kim, Goon Joung,Oh, Goo Taeg,Yoon, Do Young,Hong, Jin Tae Wiley Subscription Services, Inc., A Wiley Company 2004 Vol.50 No.11
<B>Objective</B><P>To investigate the molecular mechanisms of the antiarthritic effects of bee venom (BV) and melittin (a major component of BV) in a murine macrophage cell line (Raw 264.7) and in synoviocytes obtained from patients with rheumatoid arthritis.</P><B>Methods</B><P>We evaluated the antiarthritic effects of BV in a rat model of carrageenan-induced acute edema in the paw and in a rat model of chronic adjuvant-induced arthritis. The inhibitory effects of BV and melittin on inflammatory gene expression were measured by Western blotting, and the generation of prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and nitric oxide (NO) and the intracellular calcium level were assayed. NF-κB DNA binding and transcriptional activity were determined by gel mobility shift assay or by luciferase assay. Direct binding of BV and melittin to the p50 subunit of NF-κB was determined with a surface plasmon resonance analyzer.</P><B>Results</B><P>BV (0.8 and 1.6 μg/kg) reduced the effects of carrageenan- and adjuvant-induced arthritis. This reducing effect was consistent with the inhibitory effects of BV (0.5, 1, and 5 μg/ml) and melittin (5 and 10 μg/ml) on lipopolysaccharide (LPS; 1 μg/ml)–induced expression of cyclooxygenase 2, cytosolic phospholipase A<SUB>2</SUB>, inducible NO synthase, generation of PGE<SUB>2</SUB> and NO, and the intracellular calcium level. BV and melittin prevented LPS-induced transcriptional and DNA binding activity of NF-κB via the inhibition of IκB release and p50 translocation. BV (affinity [K<SUB>d</SUB>] = 4.6 × 10<SUP>−6</SUP>M) and melittin (K<SUB>d</SUB> = 1.2 × 10<SUP>−8</SUP>M) bound directly to p50.</P><B>Conclusion</B><P>Target inactivation of NF-κB by directly binding to the p50 subunit is an important mechanism of the antiarthritic effects of BV.</P>
Melittin Inhibits Human Prostate Cancer Cell Growth through Induction of Apoptotic Cell Death
Park Hye-Ji,Lee Yong-Kyung,Song Ho-Seub,Kim Goon-Joung,Son Dong-Ju,Lee Jae-Woong,Hong Jin-Tae Korean Society of ToxicologyKorea Environmental Mu 2006 Toxicological Research Vol.22 No.1
It was previously found that melittin inhibited $NF-{\kappa}B$ activity by reacting with signal molecules of $NF-{\kappa}B$ which is critical contributor in cancer cell growth by induction of apoptotic cell death. We here investigated whether melittin inhibits cell growth of human prostate cancer cells through induction of apoptotic cell death, and the possible signal pathways. Melittin ($0{\sim}1\;{\mu}g/ml$) inhibited prostate cancer cell growth in a dose dependent manner. Conversely related to the growth inhibitory effect, melittin increased the induction of apoptotic cell death in a dose dependent manner. Melittin also inhibited DNA binding activity of $NF-{\kappa}B$, an anti-apoptotic transcriptional factor. Consistent with the induction of apoptotic cell death and inhibition of $NF-{\kappa}B$, melittin increased the expression of pro-apoptotic proteins caspase-3, and Bax but down-regulated anti-apoptotic protein Bcl-2. These findings suggest that melittin could inhibit prostate cancer cell growth, and this effect may be related with the induction of apoptotic cell death via inactivation of $NF-{\kappa}B$.
Melittin Inhibits Human Prostate Cancer Cell Growth through Induction of Apoptotic Cell Death
Hye Ji Park,Yong Kyung Lee,Ho Seub Song,Goon Joung Kim,Dong Ju Son,Jae Woong Lee,Jin Tae Hong 한국독성학회 2006 Toxicological Research Vol.22 No.1
It was previously found that melittin inhibited NF-κB activity by reacting with signal molecules of NF-κB which is critical contributor in cancer cell growth by induction of apoptotic cell death. We here investigated whether melittin inhibits cell growth of human prostate cancer cells through induction of apoptotic cell death, and the possible signal pathways. Melittin (0~1 ㎍/㎖) inhibited prostate cancer cell growth in a dose dependent manner. Conversely related to the growth inhibitory effect, melittin increased the induction of apoptotic cell death in a dose dependent manner. Melittin also inhibited DNA binding activity of NF-κB, an anti-apoptotic transcriptional factor. Consistent with the induction of apoptotic cell death and inhibition of NF-κB, melittin increased the expression of pro-apoptotic proteins caspase-3, and Bax but down-regulated anti-apoptotic protein Bcl-2. These findings suggest that melittin could inhibit prostate cancer cell growth, and this effect may be related with the induction of apoptotic cell death via inactivation of NF-κB.