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Park, Sang Hyun,Lee, Pyung Bok,Choe, Ghee Young,Moon, Jee Yeon,Nahm, Francis Sahngun,Kim, Yong Chul The Korean Pain Society 2014 The Korean Journal of Pain Vol.27 No.3
Background: A lipo-prostaglandin E1 agonist is effective for the treatment of neurological symptoms of spinal stenosis when administered by an oral or intravenous route. we would like to reveal the therapeutic effect of an epidural injection of lipo-prostaglandin E1 on hyperalgesia in foraminal stenosis. Methods: A total of 40 male Sprague-Dawley rats were included. A small stainless steel rod was inserted into the L5/L6 intervertebral foramen to produce intervertebral foraminal stenosis and chronic compression of the dorsal root ganglia (DRG). The rats were divided into three groups: epidural PGE1 (EP) (n = 15), saline (n = 15), and control (n = 10). In the EP group, $0.15{\mu}g{\cdot}kg-1$ of a lipo-PGE1 agonist was injected daily via an epidural catheter for 10 days from postoperative day 3. In the saline group, saline was injected. Behavioral tests for mechanical hyperalgesia were performed for 3 weeks. Then, the target DRG was analyzed for the degree of chromatolysis, chronic inflammation, and fibrosis in light microscopic images. Results: From the fifth day after lipo-PGE1 agonist injection, the EP group showed significant recovery from mechanical hyperalgesia, which was maintained for 3 weeks (P < 0.05). Microscopic analysis showed much less chromatolysis in the EP group than in the saline or control groups. Conclusions: An epidurally administered lipo-PGE1 agonist relieved neuropathic pain, such as mechanical hyperalgesia, in a rat foraminal stenosis model, with decreasing chromatolysis in target DRG. We suggest that epidurally administered lipo-PGE1 may be a useful therapeutic candidate for patients with spinal stenosis.
( Sang Hyun Park ),( Pyung Bok Lee ),( Ghee Young Choe ),( Jee Yeon Moon ),( Francis Sahngun Nahm ),( Yong Chul Kim ) 대한통증학회 2014 The Korean Journal of Pain Vol.27 No.3
Background: A lipo-prostaglandin E1 agonist is effective for the treatment of neurological symptoms of spinal stenosis when administered by an oral or intravenous route. we would like to reveal the therapeutic effect of an epidural injection of lipo-prostaglandin E1 on hyperalgesia in foraminal stenosis. Methods: A total of 40 male Sprague-Dawley rats were included. A small stainless steel rod was inserted into the L5/L6 intervertebral foramen to produce intervertebral foraminal stenosis and chronic compression of the dorsal root ganglia (DRG). The rats were divided into three groups: epidural PGE1 (EP) (n = 15), saline (n = 15), and control (n = 10). In the EP group, 0.15цg.kg-1 of a lipo-PGE1 agonist was injected daily via an epidural catheter for 10 days from postoperative day 3. In the saline group, saline was injected. Behavioral tests for mechanical hyperalgesia were performed for 3 weeks. Then, the target DRG was analyzed for the degree of chromatolysis, chronic inflammation, and fibrosis in light microscopic images. Results: From the fifth day after lipo-PGE1 agonist injection, the EP group showed significant recovery from mechanical hyperalgesia, which was maintained for 3 weeks (P < 0.05). Microscopic analysis showed much less chromatolysis in the EP group than in the saline or control groups. Conclusions: An epidurally administered lipo-PGE1 agonist relieved neuropathic pain, such as mechanical hyperalgesia, in a rat foraminal stenosis model, with decreasing chromatolysis in target DRG. We suggest that epidurally administered lipo-PGE1 may be a useful therapeutic candidate for patients with spinal stenosis.
박현재,오수기,신용현,정광화,Park, Hyon-Jae,Oh, Soo-Ghee,Shin, Yong-Hyeon,Chung, Kwang-Hwa 한국진공학회 2008 Applied Science and Convergence Technology Vol.17 No.4
진공 챔버 내부에서 열접촉된 시료가열장치와 시료 사이의 열전달 현상을 고찰하였다. 열전달은 가스 유량과 기체 압력에 따른 대류현상, 시료와 접촉하는 기판가열장치의 표면 거칠기 및 접촉압력에 따른 전도현상, 기판가열장치의 표면 방사율에 따른 복사현상으로 나누어 푸리에 식과 슈테판-볼츠만 식을 이용하여 열흐름 값을 분석하였다. 실험은 시료가열장치의 온도를 $100\;-\;500^{\circ}C$ 사이에서 일정하게 유지하면서 300 mTorr - 1 Torr 사이의 압력에 따른 시료의 온도를 측정하고, 푸리에 식과 슈테판-볼츠만 식을 이용하여 열흐름 값을 계산하였다. 열흐름 값의 산출에 사용된 푸리에 계수의 정확성을 확인하기 위해, 역으로 열흐름 값으로부터 온도차를 구하는 방법을 사용하였으며 0.33 % 오차 내에서 재현됨을 확인하였다. Heat transfer between substrate and substrate-heater in low vacuum was investigated. The convection related with gas flow and pressure, the heat conduction considering surface roughness and contact pressure, and the heat loss by radiation depending on the surface emissivity were considered. The coefficient of heat conduction $h_c$ in the Fourier's law were determined experimentally from the temperature difference between the substrate and the substrate-heater in the range of substrate-heater temperature $100\;-\;500^{\circ}C$, in the pressures of 300 mTorr - 1 Torr. The temperature difference was then calculated in the reverse way for the purpose of verification, using the heat flow and the experimentally determined coefficients. The verified temperature differences were thus obtained within 0.33 % error.
지반(地盤)에 대한 구조물(構造物)의 상대강도(相對剛度)가 지반(地盤)-구조물(構造物) 상호작용(相互作用)에 미치는 영향(影響)
박영기,조양희,이용일,Park, Hyung Ghee,Joe, Yang Hee,Lee, Yong Il 대한토목학회 1985 대한토목학회논문집 Vol.5 No.1
기초지반(基礎地盤)의 유연성(柔軟性)은 구조물의 지진응답(地震應答)에 지대한 영향(影響)을 미치게 된다. 본 연구(硏究)에서는 지반(地盤)에 대한 상부구조물(上部構造物)의 상대강도(相對剛度)가 지반(地盤)-구조물(構造物) 상호작용(相互作用)에 미치는 영향을 분석하였다. 해석(解析)모델로서는 기초(基礎)슬래브의 형태와 규격은 동일하지만 상부구조(上部構造)의 강성(剛性)이 상대적으로 큰 전단벽구조(剪斷壁構造)와 강성(剛性)이 작은 뼈대 구조(構造)로 된 건물에 대하여 지반과 연계(連繫)된 집중질량(集中質量)모델을 작성하였으며, 운동방정식(運動方程式)의 해석을 위해서는 Roesset의 모드감쇠(減衰)(Modal Damping)를 이용하는 모드중첩법(重疊法)을 사용하였다. 연구결과(硏究結果), 전단벽구조물(剪斷壁構造物)의 경우 대부분의 지반조건에 대하여 지반(地盤)-구조물(構造物) 상호작용(相互作用)의 영향이 현저하게 나타나는 반면 뼈대구조물(構造物)의 경우 유연성지반(柔軟性地盤)을 제외하고는 지반(地盤)-구조물(構造物) 상호작용(相互作用)의 영향이 공학적(工學的)으로 무시될 수 있음을 확인하였다. 또 지반(地盤)-구조물(構造物) 상호작용(相互作用)의 영향이 증가(增加)할수록 구조물 상부(上部)에서의 지진응답(地震應答)이 감소(減少)하는 반면 구조물 하부(下部)에서의 지진응답(地震應答)은 오히려 증가(增加)한다는 사실을 알 수 있었다. The flexibility of base material gives considerable influences on seismic responses of a structure. The effects of relative stiffness between super-structure and base material on dynamic soil-structure interaction are evaluated by parametric studies. Two 5-story buildings are used for the study; one is shearwall structure with relatively higher fundamental frequency and the other is frame structure with relatively lower fundamental frequency. The structures are modeled as beam-sticks coupled with springs and dashpots representing the base material. Dynamic equilibrium equations of the soil-structure interaction system are sloved by mode superposition method using Rosset modal damping values. Soil-structure interaction effect is found to be major concern in seismic analysis of shearwall structure in most cases while it seldom becomes engineering problem in frame-type structure. It is also found that seismic responses at lower elevation of the super-structure are amplified though they decrease at higher elevation as soil-structure interaction effects of the system increase.
LC/MS/MS를 이용한 원숭이 혈액에서의 Doxifluridine과 대사체 5-FU 동시분석법 개발 및 Validation
우영아,김기환,김원,이종화,정은주,김진호,박귀례,김충용,Woo, Young-Ah,Kim, Ghee-Hwan,Kim, Won,Lee, Jong-Hwa,Jeong, Eun-Ju,Kim, Jin-Ho,Park, Kui-Lea,Kim, Choong-Yong 대한약학회 2007 약학회지 Vol.51 No.3
A reverse-phase high performance liquid chromatography method with electrospray ionization and detection by mass spectrometry is described for the simultaneous determination of doxifluridine and its active metabolite 5-flu-orouracil (5-FU) in monkey serum. The method has greater sensitivity and simpler process than previous published methods with good accuracy and precision. A proper liquid/liquid extraction was used to extract simultaneously doxifluridine and 5-FU which has considerable difference in the polarity. Extracts were analyzed using LC/MS/MS providing a short analysis time within 5 min. The lower limit of quantification was validated at 10.0 ng/ml of serum for both doxifluridine and 5-FU. Accuracy and precision of quality control (QC) samples for both analytes met FDA Guidance criteria of ±15% for average QC accuracy with coefficients of variation less than 15%. The method will be applicable for preclinical studies and bioequivalence studies.
소간세포암에서 혈관내피세포성장인자의 발현과 재발과의 상관관계
이지현(Ji-Hyun Lee),이광웅(Kwang-Woong Lee),김성주(Sung Ju Kim),최성호(Seong Ho Choi),허진석(Jin Seok Heo),김용일(Yong Il Kim),이환효(Hwan Hyo Lee),박진완(Jin Wan Park),박철근(Cheol Keun Park),권기영(Ghee Young Kwon),조재원(Jae Won J 대한외과학회 2005 Annals of Surgical Treatment and Research(ASRT) Vol.68 No.1
Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Sung, Hyun Hwan,Jeon, Hwang Gyun,Jeong, Byong Chang,Seo, Seong Il,Jeon, Seong Soo,Lee, Hyun Moo,Choi, Han-Yong,Kwon, Ghee-Young,Park, Woong Yang,Lee, Jeeyun Neoplasia Press 2017 Translational oncology Vol.10 No.3
<P><I>PURPOSE:</I> Although targeting angiogenesis with tyrosine kinase inhibitors (TKIs) has become standard of care in the treatment of clear cell renal cell carcinoma (RCC), resistance mechanism are not fully understood, and there is a need to develop new therapeutic options overcoming them. <I>METHODS AND MATERIALS:</I> To develop a preclinical model that predicts clinical activity of novel agents in 19 RCC patients, we established patient-derived cell (PDC) and xenograft (PDX) models derived from malignant effusions or surgical specimen. RESULTS: Successful PDCs, defined as cells that maintained growth following two passages, were established in 5 of 15 malignant effusions and 1 of 4 surgical specimens. One PDC, clinically refractory to TKIs, was implanted and engrafted in mice, resulting in a comparable histology to the primary tumor. The PDC-PDX model also showed similar genomic features when tested using targeted sequencing of cancer-related genes. When we examined the drug effects of the PDX model, the tumor cells showed resistance to TKIs and everolimus <I>in vitro</I>. <I>CONCLUSION:</I> The results suggest that the PDC-PDX preclinical model we developed using malignant effusions can be a useful preclinical model to interrogate sensitivity to targeted agents based on genomic alterations.</P>