쥐 경동맥 손상 모델에서 Herpes Simplex Virus Thymidine Kinase 유전자 치료의 협착 방지 효과

김동운,김영규,오태근,조명찬,김승택 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

補中益氣湯 투여가 장거리 달리기 선수의 에너지 및 전해질 대사에 미치는 영향 : changes in the energy and electrolyte metabolism among long distance runners

송순기,금동호,오재근,이명종 동국대학교 한의학연구소 1998 東國韓醫學硏究所論文集 Vol.7 No.1

스포츠 과학 분야에서는 운동 선수들의 경기력 향상과 운동 피로의 신속한 회복을 도모하기 위하여 한약을 복용하고 그 효과와 유의성에 대하여 연구가 활발히 이루어지고 있다. 격심한 운동을 수행할 때 나타나는 Glucose 등 에너지원의 고갈, Lactate 등 대사 산물의 축적, 전해질의 불균형 등의 여러 제반 증상이 氣虛로 인하여 나타나는 전신의 증후와 유사하다고 생각하여 補中益氣湯을 투여한 후 인체의 대사 변화를 관찰함으로서 운동수행능력에 미치는 영향과 유의성을 평가하고자 하였다. 본 연구는 장거리 달리기 선수를 대상으로 2주간의 補中益氣湯의 투여가 에너지 대사 및 전해질대사에 미치는 영향을 규명하기 위하여 최대심박수의 70% 강도의 운동을 실시한 후 운동전 안정시, 운동 직후, 휴식 후 10분, 휴식 후 30분, 휴식 후 1시간으로 나누어 혈액검사를 하였을 때 나타나는 각종 변인의 반응 양상을 비교 분석하여 유의한 결과를 얻었다. 혈중 에너지 대사에서는 free fatty acid와 Lactate 반응에서 유의성 있는 차이가 나타났고, 전해질대사에서도 Na^(+), Cl-와 K^(+) 반응에서 모누 유의성 있는 차이를 나타냈다. 그러므로 補中益氣湯은 에너지 및 전해질 대사에서 유의성있는 변화를 나타내었으며 운동수행능력의 향상에 유효하였다. Objective This experimental study was designed to investigate effects of Bo-joong-ik-gi-tang administration among long distance runners on changes of the energy and electrolyte metabolism. Materials and Methods All subjects were divided randomly with two groups, Bo-joong-ik-gi-tang Group (N=4) and control group (N=4) and performed to run the 400m track with 70% of HR max about 1 hour. The blood samples were collected from antecubital vein by 5㎖ syringes at before exercise, immediateIy after exercise, recovering- 10 min, recovering-30 min, recovering-1 hour. These sampie were used to analyze for the factors of the changes on metabolic responses. Firest, the primary factors on the changes of the energy metabolism were checked ; Glucose, Free fatty acid, Lactate, LDH. Second, the primary factors on the changes of the electroIyte metabolisrn were checked ; Na^(+), Cl^(-), K^(+). Results 1. The change of the energy metabolism 1) Glucose response was not shown significant difference between two groups. 2) Free fatty acid response in Bo-joong-ik-gi-tang group was significantly increased at recover-10 min. 3) Lactate response in Bo-joong-ik-gi-tang group was significantly decreased at immediately after exercise, recover-10 min, recover-30 min. 4) LDH response was not shown significant difference between two groups. 2. The change of the electrolyte metabolism 1) Na^(+) response in Bo-joong-ik-gi-tang group was shown significant difference between two groups at before exercise. 2) C^(-) response in Bo-joong-ik-gi-tang group was significantly increased at before exercise, immediately after exercise. 3) K^(+) response in Bo-joong-ik-gi-tang group was significantly increased at recover-10 min. Conclusion According to the above results, it was shown that Bo-joong-ik-gi-tang had the positive effects on changes of the energy and electrolyte metabolism for the long distance runners.

입원 환자 영양검색 전산 프로그램 개발

안수미,윤기영,신연명,최경현,임근승,장문경,송윤미,공은희 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Background : About 30% of patients in the hospital are under nourishment. A large portion of people are undernourished when they are admitted to the hospital and in the majority of these, undernutrition develops further while in hospital. Patient-Generated subjective global assessment(PG-SGA), a method of nutritional assessment based on clinical judgment, has been widely used to assess the nutritional status of adults for both clinical and research purposes. Modified PG-SGA can be used as a nutrition screening tool, and a comprehensive nutrition assessment is desirable for those who are malnourished. The purpose of this study is to develop a simple, reliable and valid nutrition screening program(NSP). Methods : We applied the nutrition screening program(NSP) to adult inpatients who are at risk of malnutrition using the Modified Patient-Generated subjective global assessment(PG-SGA) and objective assessment(electrical medical record data). Results : Therefore simple and beneficial NSP is developed for patients with severe malnutrition. Using NSP. nutritional information of the severe malnutrition patient should be shared with the physicians and they should be taken care of by clinical dietitians to improve their nutritional status. Conclusion : The Modified PG-SGA and nutrition screening tool are simple, reliable and valid nutrition screening program(NSP).

Three newly recorded species of the tribe Ephialtini (Hymenoptera: Ichneumonidae: Pimplinae) from South Korea

Geun-Myeong Song,Jin-Kyung Choi,Jong-Wook Lee 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.04

The subfamily Pimplinae currently include 1,737 worldwide species in 77 genera. 78 species in 21 genera have been recorded from South Korea. Among them, the genera Exeristes, Gregopimpla and Paraperithous are small groups with 10, 8 and 6 species from worldwide. The existing South Korean Exeristes and Paraperithous include only one species, E. roborator (Fabricius) and P. chui (Uchida). Three species of genus Gregopimpla have been recorded from South Korea, G. himalayensis (Cameron), G. inquisitor (Scopoli) and G. kuwanae (Viereck). In this study, we report three newly recorded species Exeristes longiseta (Ratzeburg), Gregopimpla ussuriensis Kasparyan and Paraperithous gnathaulax (Thomson) from South Korea, including diagnoses, photographs of newly recorded species and keys to the species of South Korean Exeristes, Gregopimpla and Paraperithous.

Review of the Genera Delomerista, Iseropus, and Perithous (Hymenoptera: Ichneumonidae: Pimplinae) from South Korea

Geun-Myeong Song,Jin-Kyung Choi,Jong-Wook Lee 한국동물분류학회 2020 Animal Systematics, Evolution and Diversity Vol.36 No.1

The eight newly recognized species of the genera Delomerista, Iseropus, and Perithous are reported in this study: Delomerista kusuoi Uchida & Momoi, 1957, D. mandibularis (Gravenhorst, 1829), D. pfankuchi Brauns, 1905, Iseropus stercorator stercorator (Fabricius, 1793), Perithous albicinctus (Gravenhorst, 1829), P. septemcinctorius (Thunberg, 1822), P. speculator Haupt, 1954, and P. townesorum (Gupta, 1982). The genus Delomerista Förster, 1869 is a small group that includes 18 species worldwide that, for the first time, has been recorded from South Korea. Iseropus Förster, 1869 is a small group that includes nine species worldwide. The genus Perithous Holmgren, 1859 is also small group including 18 species worldwide. In this study, keys to species of these genera and illustrations and diagnoses of each species are provided.

Review of the Genera Scambus and Tromatobia (Hymenoptera: Ichneumonidae: Pimplinae) from South Korea

Geun-Myeong Song,Jong-Wook Lee 한국동물분류학회 2017 Animal Systematics, Evolution and Diversity Vol.33 No.3

We reviewed eight South Korean species of the genera Scambus Hartig, 1838 and Tromatobia Förster, 1869. Among them, the Genus Scambus Hartig, 1838 is a moderately large group that includes 152 species worldwide. The South Korean genus Scambus Hartig, 1838 only includes one species, Scambus calobatus (Gravenhorst, 1829). The Tromatobia Förster, 1869 group is a relatively small genus, including 33 worldwide species. This group is recorded for the first time from South Korea. Also, we report seven newly recorded species: Scambus nigricans (Thomson, 1877), Scambus vesicarius (Ratzeburg, 1844), Tromatobia flavistellata Uchida and Momoi, 1957, Tromatobia nipponica Uchida, 1928, Tromatobia ornata (Gravenhorst, 1829), Tromatobia ovivora (Boheman, 1821), and Tromatobia variabilis (Holmgren, 1856). A key to South Korean species of the genera Scambus Hartig, 1838 and Tromatobia Förster, 1869, diagnoses and illustrations are provided.

Three new recorded species of the Genus Endromopoda (Hymenoptera: Ichneumonidae: Pimplinae) from South Korea

Geun-Myeong Song,Jin-Kyung Choi,Jong-Wook Lee 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.10

The subfamily Pimplinae comprising more than 1,700 described species within 77 genera worldwide. Sixty-nine specieswithin 20 genera have been recorded from South Korea. Among them, the genus Endromopoda is a small sized groupin the subfamily Pimplinae with 11 described species from Nearctic, Oriental and Palaearctic regions. This genus is newlyrecorded from South Korea for the first time. Genus Endromopoda can easily be distinguished from other genera of Pimplinaeby the following characters: Distinctly depressed ovipositor, with perpendicular teeth on apex; elongated propodeum.In this study, we report three unrecorded South Korean species, Endromopoda arundinator (Fabricius,1804), Endromopoda detrita (Holmgren, 1860) and Endromopoda phragmitidis (Perkins, 1957). In addition,diagnoses, photographs of newly recorded species and a key to the species of South Korean Endromopodaare provided.

Taxonomic Study of the Genera Scambus and Tromatobia (Hymenoptera: Ichneumonidae: Pimplinae) from South Korea

Geun-Myeong Song,Jong-Wook Lee 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.04

The subfamily Pimplinae currently include 1,737 worldwide species in 77 genera. 57 species in 18 genera have been recorded from South Korea. Among them, the genus Scambus is a moderate sized group in the subfamily Pimplinae with 152 described species from Nearctic, Neotropical, Oriental and Palaearctic regions. The taxonomic study of the South Korean Scambus was initiated by Uchida (1928), who reported one species, Scambus calobatus (Gravenhorst, 1829). The genus Tromatobia is small group in this subfamily with 33 species from Afrotropical, Austrian, Nearctic, Neotropical, Oriental and Palaearctic regions. This genus was newly recorded from South Korea for the first time. In this study, we report seven unrecorded South Korean species, Scambus nigricans (Thomson, 1877), Scambus vesicarius (Ratzeburg, 1844), Tromatobia flavistellata Uchida & Momoi, 1957, Tromatobia nipponica Uchida, 1928, Tromatobia ornata (Gravenhorst, 1829), Tromatobia ovivora (Boheman, 1821) and Tromatobia variabilis (Holmgren, 1856).

Blood KL-6 Predicts Disease Progression in IPF Patients Receiving Antifibrotic Therapy

( Myeong Geun Choi ),( Sun Mi Choi ),( Jae Ha Lee ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0

Background The use of antifibrotic agent can reduce disease progression (DP) in patients with idiopathic pulmonary fibrosis (IPF). However, prognostic biomarker for DP in IPF patients receiving antifibrotic therapy is not well known. The purpose of this study was to evaluate predicting values of serum Krebs von den Lungen-6 (KL-6) for DP in patients with IPF. Methods Clinical data were retrospectively analyzed in 77 IPF patients who initiate antifibrotic therapy. DP was defined as a relative decline in forced vital capacity (FVC) ≥10% or diffusion of carbon monoxide (DLco) ≥15%, acute exacerbation, or deaths during 6 months after antifibrotic therapy. Results Of total patients, the mean age was 67.4 years and male were 76.6%. The median follow-up period after initiation of antifibrotic therapy was 8.0 months, and DP occurred in 19 patients (24.7%). At baseline, patients with DP showed lower FVC, and total lung capacity (TLC), and shorter the 6-minute walk test distance (6MWD) than those without. There were no differences in baseline KL-6 and change of KL-6 for 1 month from baseline between two groups. However, in the subgroup analysis according to the baseline KL-6 levels, among patients with elevated KL-6 levels (≥500 U/mL; n=61), the absolute and relative changes of KL-6 for 1 month were higher in patients with DP than those without. In the multivariable logistic analysis adjusted by age, higher changes of KL-6 for 1 month ([absolute] odds ratio [OR] 1.003, p=0.033; [relative] OR: 1.042, p=0.027, respectively) were associated with DP, along with lower FVC and shorter 6MWD. KL-6 changes for 1 month were also correlated with FVC change for 6 months (Figure 1). Conclusions Our data suggest that the change of KL-6 for 1 month are useful in predicting DP in IPF patients receiving antifibrotic therapy, along with baseline FVC and 6MWT distance.

The effects of pulmonary rehabilitation during chest radiotherapy in patients with malignancy

( Myeong Geun Choi ),( Jae Seung Lee ),( Yeon-mok Oh ),( Sang-do Lee ),( Sei Won Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Radiotherapy become a treatment of choice for lung cancer or esophageal cancer when surgery cannot be an option due to poor lung function. Radiotherapy can affect pulmonary function and induce pneumonitis or pneumonia, which can be fatal in patients with poor lung function. The purpose of this study is to ensure that the reduction of pulmonary function tests (PFT) after radiotherapy can be minimized through pulmonary rehabilitation (PR). Methods: The patients, who initiated pulmonary rehabilitation with radiotherapy for lung cancer from January 2018 to June 2019, were enrolled. The results of the pulmonary function test and 6 minute walk test (6MWT) conducted within six months prior and after radiotherapy were analyzed. Results: A total of 10 patients performed pulmonary rehabilitation at least once a week during chest radiotherapy, and conducted pulmonary function test prior and after radiotherapy. The mean age was 68 and they were all male. Nine patients had non-small cell lung cancer, one had esophageal cancer and seven had COPD. The FEV1 (%) and FEV/FVC (%) were significantly increased by 10.5% (p=0.004) and 6.2% (p=0.038), respectively, compared with baseline (55.6%, 51.6%). The 6MWT results were also significantly increased from 405.6m to 466.9m (p=0.009). Conclusions: Pulmonary rehabilitation during chest radiotherapy improved pulmonary function and exercise capacity in patients with lung or esophageal cancer. This can be an important basis for further studies to identify the effects of pulmonary rehabilitation during chest radiotherapy through large study with long-term follow up period.