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RECENT PROGRESS ON LASER DRIVEN ACCELERATORS AND APPLICATIONS
LEEMANS W. P.,ESAREY E.,GEDDES C.G.R.,SCHROEDER C. B.,TOTH CS. Korean Nuclear Society 2005 Nuclear Engineering and Technology Vol.37 No.5
Laser driven accelerators promise to provide an alternative to conventional accelerator technology. They rely on the excitation of large amplitude density waves in a plasma by the photon pressure of an intense laser. The density oscillations in which electrons and ions are separated, result in extremely large longitudinal electric fields that can be several orders of magnitude larger than those that are used in today's radio-frequency accelerators. Whereas this principle had been demonstrated experimentally for nearly two decades, it was not until 2004 that the production of high quality electron beams around 100 MeV was demonstrated. Analysis, aided by particle-in-cell simulations, as well as experiments with various plasma lengths and densities, indicate that tailoring the length of the accelerator, together with loading of the accelerating structure with beam, are the keys to production of mono-energetic electron beams. Increasing the energy towards a GeV and beyond will require reducing the plasma density and design criteria are discussed for an optimized accelerator module. The current progress and future directions are summarized through comparison with conventional accelerators, highlighting the unique short and long term prospects for intense radiation sources and high energy accelerators based on laser-drivenplasma accelerators.
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RECENT PROGRESS ON LASER DRIVENACCELERATORS AND APPLICATIONS
W. P. LEEMANS,E. ESAREY,C. G. R. GEDDES,C. B. SCHROEDER,CS. TOTH 한국원자력학회 2005 Nuclear Engineering and Technology Vol.37 No.5
Laser driven accelerators promise to provide an alternative to conventional accelerator technology. They rely on the excitation of large amplitude density waves in a plasma by the photon pressure of an intense laser. The density oscillations in which electrons and ions are separated, result in extremely large longitudinal electric fields that can be several orders of magnitude larger than those that are used in today’s radio-frequency accelerators. Whereas this principle had been demonstrated experimentally for nearly two decades, it was not until 2004 that the production of high quality electron beams around 100 MeV was demonstrated. Analysis, aided by particle-in-cell simulations, as well as experiments with various plasma lengths and densities, indicate that tailoring the length of the accelerator, together with loading of the accelerating structure with beam, are the keys to production of mono-energetic electron beams. Increasing the energy towards a GeV and beyond will require reducing the plasma density and design criteria are discussed for an optimized accelerator module. The current progress and future directions are summarized through comparison with conventional accelerators, highlighting the unique short and long term prospects for intense radiation sources and high energy accelerators based on laser-drivenplasma accelerators.
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Thomas B. Pepinsky,Erik Martinez Kuhonta,Dan Slater,Tuong Vu,Barbara Geddes,Duncan McCargo,Richard Robison 동아시아연구원 2010 Journal of East Asian Studies Vol.10 No.2
Comparative politics has witnessed periodic debates between proponents of contextually sensitive area studies research and others who view such work as unscientific,noncumulative, or of limited relevance for advancing broader social science knowledge. In Southeast Asia in Political Science: Theory, Region, and Qualitative Analysis, edited by Erik Martinez Kuhonta, Dan Slater, and Tuong Vu, a group of bright, young Southeast Asianists argue that contextually sensitive research in Southeast Asia using qualitative research methods has made fundamental and lasting contributions to comparative politics. They challenge other Southeast Asianists to assert proudly the contributions that their work has made and urge the rest of the comparative politics discipline to take these contributions seriously. This symposium includes four short critical reviews of Southeast Asia in Political Science by political scientists representing diverse scholarly traditions. The reviews address both the methodological and the theoretical orientations of the book and are followed by a response from the editors.
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Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box
Kronstad, James W.,Attarian, Rodgoun,Cadieux, Brigitte,Choi, Jaehyuk,D'Souza, Cletus A.,Griffiths, Emma J.,Geddes, Jennifer M. H.,Hu, Guanggan,Jung, Won Hee,Kretschmer, Matthias,Saikia, Sanjay,Wang, J Nature Publishing Group, a division of Macmillan P 2011 Nature reviews. Microbiology Vol.9 No.3
Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen because of its tendency to infect immunocompromised individuals, particularly those infected with HIV. However, this view has been challenged by the recent discovery of specialized interactions between the fungus and its mammalian hosts, and by the emergence of the related species Cryptococcus gattii as a primary pathogen of immunocompetent populations. In this Review, we highlight features of cryptococcal pathogens that reveal their adaptation to the mammalian environment. These features include not only remarkably sophisticated interactions with phagocytic cells to promote intracellular survival, dissemination to the central nervous system and escape, but also surprising morphological and genomic adaptations such as the formation of polyploid giant cells in the lung.
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Real-time data monitoring for ulcerative colitis: patient perception and qualitative analysis
Alissa Walsh,Lawrence Matini,Christopher Hinds,Vanashree Sexton,Oliver Brain,Satish Keshav,John Geddes,Guy Goodwin,Gary Collins,Simon Travis,Michele Peters 대한장연구학회 2019 Intestinal Research Vol.17 No.3
Background/Aims: TrueColours ulcerative colitis (TCUC) is a comprehensive web-based program that functions through email, providing direct links to questionnaires. Several similar programs are available, however patient perspectives are unexplored. Methods: A pilot study was conducted to determine feasibility, usability and patient perceptions of real-time data collection (daily symptoms, fortnightly quality of life, 3 monthly outcomes). TCUC was adapted from a web-based program for patients with relapsing-remitting bipolar disorder, using validated UC indices. A semi-structured interview was developed and audio-recorded face-to-face interviews were conducted after 6 months of interaction with TCUC. Transcripts were coded in NVivo11, a qualitative data analysis software package. An inductive approach and thematic analysis was conducted. Results: TCUC was piloted in 66 patients for 6 months. Qualitative analysis currently defies statistical appraisal beyond “data saturation,” even if it has more influence on clinical practice than quantitative data. A total of 28 face-to-face interviews were conducted. Six core themes emerged: awareness, control, decision-making, reassurance, communication and burden of treatment. There was a transcending overarching theme of patient empowerment, which cut across all aspects of the TCUC experience. Conclusions: Patient perception of the impact of real-time data collection was extremely positive. Patients felt empowered as a product of the self-monitoring format of TCUC, which may be a way of improving self-management of UC whilst also decreasing the burden on the individual and healthcare services.
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