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- 저자 : Richard Robison (검색결과 2 건)
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Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat
Alegre, Melissa Marie,Knowles, McKay Hovis,Robison, Richard A.,O'Neill, Kim Leslie Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Cancer prevention is rapidly emerging as a major strategy to reduce cancer mortality. In the field of breast cancer, significant strides have recently been made in the understanding of underlying preventive mechanisms. Currently, three major strategies have been linked to an increase in breast cancer risk: obesity, lack of physical exercise, and high levels of saturated dietary fat. As a result, prevention strategies for breast cancer are usually centered on these lifestyle factors. Unfortunately, there remains controversy regarding epidemiological studies that seek to determine the benefit of these lifestyle changes. We have identified crucial mechanisms that may help clarify these conflicting studies. For example, recent reports with olive oil have demonstrated that it may influence crucial transcription factors and reduce breast tumor aggressiveness by targeting HER2. Similarly, physical exercise reduces sex hormone levels, which may help protect against breast cancer. Obesity promotes tumor cell growth and cell survival through upregulation of leptin and insulin-like growth factors. This review seeks to discuss these underlying mechanisms, and more behind the three major prevention strategies, as a means of understanding how breast cancer can be prevented.
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Thomas B. Pepinsky,Erik Martinez Kuhonta,Dan Slater,Tuong Vu,Barbara Geddes,Duncan McCargo,Richard Robison 동아시아연구원 2010 Journal of East Asian Studies Vol.10 No.2
Comparative politics has witnessed periodic debates between proponents of contextually sensitive area studies research and others who view such work as unscientific,noncumulative, or of limited relevance for advancing broader social science knowledge. In Southeast Asia in Political Science: Theory, Region, and Qualitative Analysis, edited by Erik Martinez Kuhonta, Dan Slater, and Tuong Vu, a group of bright, young Southeast Asianists argue that contextually sensitive research in Southeast Asia using qualitative research methods has made fundamental and lasting contributions to comparative politics. They challenge other Southeast Asianists to assert proudly the contributions that their work has made and urge the rest of the comparative politics discipline to take these contributions seriously. This symposium includes four short critical reviews of Southeast Asia in Political Science by political scientists representing diverse scholarly traditions. The reviews address both the methodological and the theoretical orientations of the book and are followed by a response from the editors.
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