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Comparative aspects of microRNA expression in canine and human cancers
Kabiru Sahabi,Gayathri T. Selvarajah,Rasedee Abdullah,Yoke Kqueen Cheah,Geok Chin Tan 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.2
MicroRNAs (miRNAs) have important roles in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have beenidentified, and many are conserved among vertebrates and invertebrates. Regulation of miRNA is the most common mode ofpost-transcriptional gene regulation. The miRNAs that are involved in the initiation and progression of cancers are termed oncomiRs andseveral of them have been identified in canine and human cancers. Similarly, several miRNAs have been reported to be down-regulated incancers of the two species. In this review, current information on the expression and roles of miRNAs in oncogenesis and progression of humanand canine cancers, as well the roles miRNAs have in cancer stem cell biology, are highlighted. The potential for the use of miRNAs astherapeutic targets in personalized cancer therapy in domestic dogs and their possible application in human cancer counterparts are alsodiscussed.