Recommended Method for Radioisotope Red-Cell Survival Studies

Berlin, N.I.,Dudley, R.A.,Garby, L.,Heimpel, H.,Lee, M.,Lewis, S.M.,McIntyre, P.,Mollison, P.L.,Najean, Y.,Pettit, J. The Korean Society of Nuclear Medicine 1980 핵의학 분자영상 Vol.14 No.2

혈액질환(血液疾患), 특히 용혈성빈혈(溶血性貧血)을 수반(隨伴)한 경우(境遇)에 적혈구(赤血球)의 생성(生成), 파괴과정(破壞過程)을 정확히 파악하는 것은 빈혈(貧血)의 발생기전(發生機轉) 및 병인(病因), 치료(治療), 예후(豫後) 결정(決定)에 매우 중요(重要)하다. 적혈수명측정법(赤血壽命測定法)은 최근(最近) 방사성(放射性)동위원소(同位元素)를 이용(利用)한 방법(方法)이 소개된 이래 널리 시행(施行)되어 왔다. 그러나 그 방법(方法) 및 결과(結果) 해석(解釋)에 표준화(標準化)가 되어 있지 않았던 중 1971년 ICSH (International Committee for Standardization in Hematology)에서 expert panel을 갖고 ICSH 추천 방법(方法)을 발표(發表)하였고, 본지(本誌)에서도 그 내용(內容)을 게재(揭載)한 바 있다. 1980년 ICSH는 전문기관 및 전문가의 협조(協調)를 얻어 다시 expert panal을 갖은 후 1971년에 추진한 적혈구수명측정법(赤血球壽命測定法)의 일부(一部)를 수정(修正)하여 ICSH의 표준방법(標準方法)으로 발표(發表)하였다. 개정(改正)된 표준방법(標準方法)과 1971년 ICSH추친 방법(方法)과의 차이(差異)는 다음과 같다. $^{51}Cr$표지방법중(標識方法中) 참고방법(參考方法)(Reference method)인 ACD법(法)에 수정(修正)을 가하여, ACD solution 구성성분(構成成分)이 차이(差異)가 있으며, 표지(標識)$^{51}Cr$의 양(量)을 체중당(體重當) $1.5{\mu}Ci$에서 $0.5{\mu}Ci$로 제한(制限)시켰다. 투여방법(投與方法)에 대한 언급 특히 투여하는 표지적혈구(標識赤血球)의 용적을 정확하게 측정 하기 위한 방법 4가지를 추가하였고, 검체준비(檢體準備) 과정중(過程中)의 pipet error를 방지(防止)하기위해 일정(一定)한 형태의 pipet을 사용(使用)하며, 1ml의 tuterculin syringe는 사용(使用)하지 않기로 하였다. 또한 결과분석시(結果分析時) 혈구용적(血球容積)의 항정성(恒定性)을 위해 Sodium pertectnetate($^{99m}Tc$)를 이용(利用)해 혈구용적(血球容積)을 반복(反復)해 측정(測定)하도록 하였으며 이때 사용(使用)하는 방사성동위원소(放射性同位元素)는 $^{32}P$ 대신 $^{99m}Tc$로 하였다. 결과해석시(結果解釋時) IgG 항체(抗體) 또는 IgM 항체(抗體)에 따른 차이점(差異點)에 대한 고려가 추가(追加)되었다. ICSH와 국제혈액학회(國際血液學會)에서 수정(修正)된 ICSH 표준방법(標準方法)에 의한 적혈수명측정법(赤血壽命測定法)을 널리 소개(紹介)하여 결과(結果)의 표준화(標準化)를 기하고자 연관잡지(聯관(關)雜誌)에 게재(揭載)할 것을 요청(要請)하였기에 전문(全文)을 본지(本誌)에 소개(紹介)하고자 한다.

Characterization of Micro Crystalline Cellulose on the surface of Graphene/Graphene Oxide Sheets by Thermal Exfoliation Method

Garbis Atam AKCEOGLU,Panuphong POOTAWANG,Nagahiro SAITO 한국표면공학회 2013 한국표면공학회 학술발표회 초록집 Vol.2013 No.11

Uncommon Indications for Reverse Total Shoulder Arthroplasty

Yoon Suk Hyun,Gazi Huri,Nickolas G. Garbis,Edward G. McFarland 대한정형외과학회 2013 Clinics in Orthopedic Surgery Vol.5 No.4

Total shoulder arthroplasty and shoulder hemiarthroplasty have been the traditional method for treating a variety of shoulder conditions, including arthritis, cuff tear arthropathy, and some fracture types. However, these procedures did not provide consistently good results for patients with torn rotator cuffs. The development of the reverse prosthesis by Grammont in the late 20th century revolutionized the treatment of the rotator-cuff-deficient shoulder with arthritis. The main indication for the reverse prosthesis remains the patient with cuff tear arthropathy who has pain and loss of motion. Because the reverse total shoulder arthroplasty produced such good results in these patients, the indications for the reverse prosthesis have expanded to include other shoulder conditions that have previously been difficult to treat successfully and predictably. This review discusses and critically reviews these newer indications for the reverse total shoulder arthroplasty

Delayed surgical repair of the deltoid following acromioplasty: a case report

Zohaib Sherwani,Chase Kelley,Hassan Farooq,Nickolas G. Garbis 대한견주관절의학회 2022 대한견주관절의학회지 Vol.25 No.4

Currently, the literature contains few studies that describe any potential complications following arthroscopic acromioplasty. Because part of the anterior deltoid originates from the anterior acromion, there is a risk for violation and subsequent iatrogenic rupture or avulsion during this procedure. This type of injury can be a devastating problem for patients that may lead to poor function and debilitating pain. We present a patient with deltoid insufficiency following arthroscopic acromioplasty who elected to proceed with operative management with a planned arthroscopic evaluation of the shoulder followed by an open deltoid repair. At the final follow-up visit 2.5 years postoperatively, the patient reported improved pain from baseline and no residual disability and was able to perform most activities of daily living without difficulty. This case serves as an example of a surgical repair for a deltoid avulsion following arthroscopic acromioplasty. As there is still a lack of standard guidelines, our suture repair technique can be considered one method of treatment for this type of injury.

In-vitro Antimicrobial Activity Phytochemical and Cytotoxicity of Methanolic Fruits Extract of Capsicum frutescent

Elbashir, Habiballah A.,Mubarak, Elnaeim E.,Kabbashi, Ahmed S.,Garbi, Mohamed I.,Elshikh, Ahmed A. Korea FoodHealth Convergence Association 2018 식품보건융합연구 (KJFHC) Vol.4 No.4

Capsicum frutescen is known in Sudan, is one of the most commonly used pepper species in cooking and in Sudanese folk medicine. The present study was conducted to investigate antimicrobial (bacteria and fungi) and cytotoxicity (Brine Shrimp Lethality Test) of methanolic extract of Capsicum frutescen (fruits). The extract have been tested in the present study to investigate the in vitro potential effects against Gram positive, Gram negative bacteria and fungi. The selected organisms were Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and Candida albicans using the cup plate agar diffusion method. The methanol extract of Capsicum frutescen (fruits) exhibited inhibitory effects against Escherichia coli with zone of inhibition (23 mm) and Klebsiella pneumonia with zone of inhibition (17 mm). The phytochemical screening revealed the presence of Tannins, Saponin, Alkaloids, Anthroquinoles and Terpenoids. The Cytotoxicity of methanolic extract of Capsicum frutescens was $LD_{50}$ $64.68{\mu}g/ml$. The activity and presence of compounds known to be biologically active are a validation for the use of Capsicum as a food ingredient and as a therapeutic element of traditional medicine.

The impact of modern airport security protocols on patients with total shoulder replacements

Michael D. Scheidt,Neal Sethi,Ballard Matthew,Michael Wesolowski,Dane Salazar,Nickolas Garbis 대한견주관절학회 2023 대한견주관절의학회지 Vol.26 No.4

Background: Advancements in airport screening measures in response to 9/11 have resulted in increased false alarm rates for patients with orthopedic and metal implants. With the implementation of millimeter-wave scanning technology, it is important to assess the changes in airport screening experiences of patients who underwent total shoulder arthroplasty (TSA). Methods: Here, 197 patients with prior anatomic and reverse TSA completed between 2013 and 2020 responded to a questionnaire regarding their experiences with airport travel screening after their operation. Of these patients, 86 (44%) stated that they had traveled by plane, while 111 (56%) had not. The questionnaire addressed several measures including the number of domestic and international flights following the operation, number of false alarm screenings by the millimeter-wave scanner, patient body habitus, and presence of additional metal implants. Results: A total of 53 patients (62%) responded “yes” to false screening alarms due to shoulder arthroplasty. The odds of a false screening alarm for patients with other metal implants was 5.87 times that of a false screening alarm for patients with no other metal implants (P<0.1). Of a reported 662 flights, 303 (45.8%) resulted in false screening alarms. Greater body mass index was not significantly lower in patients who experienced false screening alarms (P=0.30). Conclusions: Patients with anatomic and reverse TSA trigger false alarms with millimeter-wave scanners during airport screening at rates consistent with prior reports following 9/11. Patient education on the possibility of false alarms during airport screening is important until improvements in implant identification are made. Level of evidence: IV.

Core decompression for early-stage avascular necrosis of the humeral head: current concepts and techniques

Michael D. Scheidt,Saleh Aiyash,Dane Salazar,Nickolas Garbis 대한견주관절의학회 2023 대한견주관절의학회지 Vol.26 No.2

Avascular necrosis (AVN) of the humeral head is a rare, yet detrimental complication. Left untreated, humeral head AVN frequently progresses to subchondral fracturing and articular collapse. Cases of late-stage humeral head AVN commonly require invasive procedures including humeral head resurfacing, hemiarthroplasty, and total shoulder arthroplasty (TSA) to improve clinical outcomes. However, in cases of early-stage AVN, core decompression of the humeral head is a viable and efficacious short-term treatment option for patients with pre-collapse AVN of the humeral head to improve clinical outcomes and prevent disease progression. Several techniques have been described, however, a percutaneous, arthroscopic-assisted technique may allow for accurate staging and concomitant treatment of intraarticular pathology during surgery, although further long-term clinical studies are necessary to assess its overall outcomes compared with standard techniques. Biologic adjunctive treatments, including synthetic bone grafting, autologous mesenchymal stem cell/bone marrow grafts, and bone allografts are viable options for reducing the progression of AVN to further collapse in the short term, although long-term follow-up with sufficient study power is lacking in current clinical studies. Further long-term outcome studies are required to determine the longevity of core decompression as a conservative measure for early-stage AVN of the humeral head.

An objective assessment of the impact of tendon retraction on sleep efficiency in patients with full-thickness rotator cuff tears: a prospective cohort study

Ashley E. MacConnell,William Davis,Rebecca Burr,Andrew Schneider,Lara R Dugas,Cara Joyce,Dane H. Salazar,Nickolas G. Garbis 대한견주관절의학회 2023 대한견주관절의학회지 Vol.26 No.2

Background: Sleep quality, quantity, and efficiency have all been demonstrated to be adversely affected by rotator cuff pathology. Previous measures of assessing the impact of rotator cuff pathology on sleep have been largely subjective in nature. This study was undertaken to objectively analyze this relationship through the use of activity monitors. Methods: Patients with full-thickness rotator cuff tears at a single institution were prospectively enrolled between 2018 and 2020. Waist-worn accelerometers were provided for the patients to use each night for 14 days. Sleep efficiency was calculated using the ratio of the time spent sleeping to the total amount of time that was spent in bed. Retraction of the rotator cuff tear was classified using the Patte staging system. Results: This study included 36 patients: 18 with Patte stage 1 disease, 14 with Patte stage 2 disease, and 4 patients with Patte stage 3 disease. During the study, 25 participants wore the monitor on multiple nights, and ultimately their data was used for the analysis. No difference in the median sleep efficiency was appreciated amongst these groups (P>0.1), with each cohort of patients demonstrating a generally high sleep efficiency. Conclusions: The severity of retraction of the rotator cuff tear did not appear to correlate with changes in sleep efficiency for patients (P>0.1). These findings can better inform providers on how to counsel their patients who present with complaints of poor sleep in the setting of full-thickness rotator cuff tears.