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Gaonkar, Santhosh L.,Ahn, Chuljin,Princia, Princia,Shetty, Nitinkumar S. Korean Chemical Society 2014 대한화학회지 Vol.58 No.4
Benzothieno[2,3-d]pyrimidines (2,3,4) and benzothieno[3,2-e][1,3,4]triazolo[4,3-c] pyrimidines (5a-c) were synthesized from the precursor 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 by employing the conventional method as well as the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue 1 was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses are more efficient than the conventional classical heating methods. The structures of all the compounds were ascertained by spectral and analytical data.
Naiktari, Ritam S.,Gaonkar, Pratima,Gurav, Abhijit N.,Khiste, Sujeet V. Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.3
Purpose: Triphala is a combination of three medicinal plants, extensively used in Ayurveda since ancient times. Triphala mouthwash is used in the treatment of periodontal diseases because of its antimicrobial and antioxidant properties. The aim of this study is to compare the efficacy of triphala mouthwash with 0.2% chlorhexidine in hospitalized periodontal disease patients. Methods: In this double-blind, randomized, multicenter clinical trial, 120 patients were equally divided into three groups. Patients in group A were advised to rinse their mouths with 10 mL of distilled water, group B with 0.2% chlorhexidine, and group C with triphala mouthwash for 1 minute twice daily for two weeks. The plaque index (PI) and the gingival index (GI) were recorded on the first and the fifteenth day. Results: There was no significant difference when the efficacy of triphala was compared with 0.2% chlorhexidine in hospitalized patients with periodontal disease. However, a statistically significant difference was observed in PI and GI when both group B and group C were compared with group A and also within groups B and C, after 15 days (P<0.05). Conclusions: The triphala mouthwash (herbal) is an effective antiplaque agent like 0.2% chlorhexidine. It is significantly useful in reducing plaque accumulation and gingival inflammation, thereby controlling periodontal diseases in every patient. It is also cost effective, easily available, and well tolerable with no reported side effects.
Ritam S. Naiktari,Pratima Gaonkar,Abhijit N. Gurav,Sujeet V. Khiste 대한치주과학회 2014 Journal of Periodontal & Implant Science Vol.44 No.3
Purpose: Triphala is a combination of three medicinal plants, extensively used in Ayurvedasince ancient times. Triphala mouthwash is used in the treatment of periodontal diseasesbecause of its antimicrobial and antioxidant properties. The aim of this study is to comparethe efficacy of triphala mouthwash with 0.2% chlorhexidine in hospitalized periodontaldisease patients. Methods: In this double-blind, randomized, multicenter clinical trial, 120 patients wereequally divided into three groups. Patients in group A were advised to rinse their mouthswith 10 mL of distilled water, group B with 0.2% chlorhexidine, and group C with triphalamouthwash for 1 minute twice daily for two weeks. The plaque index (PI) and the gingivalindex (GI) were recorded on the first and the fifteenth day. Results: There was no significant difference when the efficacy of triphala was comparedwith 0.2% chlorhexidine in hospitalized patients with periodontal disease. However, a statisticallysignificant difference was observed in PI and GI when both group B and group Cwere compared with group A and also within groups B and C, after 15 days (P<0.05). Conclusions: The triphala mouthwash (herbal) is an effective antiplaque agent like 0.2%chlorhexidine. It is significantly useful in reducing plaque accumulation and gingival inflammation,thereby controlling periodontal diseases in every patient. It is also cost effective,easily available, and well tolerable with no reported side effects.
A Facile Solvent and Catalyst Free Synthesis of New Dihydro Pyrimidinones as Antimicrobial Agents
Hegde, Hemant,Ahn, Chuljin,Gaonkar, Santosh L.,Shetty, Nitinkumar S. Korean Chemical Society 2019 대한화학회지 Vol.63 No.6
An efficient one pot multicomponent synthesis of pyrimidinone derivatives of Biginelli type is described. 4-amino-6-aryl-pyrimidine-5-carbonitrile molecules were synthesized efficiently via three-component Biginelli-type condensation of aldehyde, malononitrile, and semicarbazone as urea substituent in the presence of a catalytic amount of PEG-400 as green medium under microwave irradiation. The reactions proceeded efficiently in the presence of microwave radiation to afford the desired products in good to excellent yields. Products have been confirmed by IR, and NMR spectral analysis. All the molecules were tested for their antimicrobial activity against E. coli, S. aureus, P. aeruginosa and C. tropicalis. Some of the compounds have shown moderate to good inhibition efficiency against both gram-positive and gram-negative bacteria. The potent activity was observed against the fungal species with minimum inhibition concentration 12.5 ㎍/mL.
A Facile Solvent and Catalyst Free Synthesis of New Dihydro Pyrimidinones as Antimicrobial Agents
Hemant Hegde,안철진,Santosh L. Gaonkar,Nitinkumar S. Shetty 대한화학회 2019 대한화학회지 Vol.63 No.6
An efficient one pot multicomponent synthesis of pyrimidinone derivatives of Biginelli type is described. 4- amino-6-aryl-pyrimidine-5-carbonitrile molecules were synthesized efficiently via three-component Biginelli-type condensation of aldehyde, malononitrile, and semicarbazone as urea substituent in the presence of a catalytic amount of PEG-400 as green medium under microwave irradiation. The reactions proceeded efficiently in the presence of microwave radiation to afford the desired products in good to excellent yields. Products have been confirmed by IR, and NMR spectral analysis. All the molecules were tested for their antimicrobial activity against E. coli, S. aureus, P. aeruginosa and C. tropicalis. Some of the compounds have shown moderate to good inhibition efficiency against both gram-positive and gram-negative bacteria. The potent activity was observed against the fungal species with minimum inhibition concentration 12.5 µg/mL.
Chaouiki, A.,Lgaz, H.,Chung, Ill-Min,Ali, I.H.,Gaonkar, S.L.,Bhat, K.S.,Salghi, R.,Oudda, H.,Khan, M.I. Elsevier 2018 Journal of molecular liquids Vol.266 No.-
<P><B>Abstract</B></P> <P>Two benzonitrile derivatives, namely 4-(isopentylamino)-3-nitrobenzonitrile (PANB) and 3-amino-4-(isopentylamino)benzonitrile(APAB) have been synthesized and evaluated as corrosion inhibitors for mild steel (MS) in 1 M HCl solution at 303 K by gravimetric, potentiodynamic polarization (PDP) curves, and electrochemical impedance spectroscopy (EIS) methods, as well as Density Functional Theory (DFT) and molecular dynamics (MD) simulations. The results suggest that tested compounds are excellent corrosion inhibitors for mild steel with PANB showing superior performance. Polarization measurements revealed that PANB and APAB behaved as mixed type inhibitors. The polarization resistance, according to EIS studies, found to be dependent on the inhibitor's concentration. The adsorption of PANB and APAB on mild steel surface obeyed Langmuir's adsorption isotherm. On the one hand, DFT and MD simulations are being used to explain the effect of the molecular structure on the corrosion inhibition efficiency and on the other hand to simulate the adsorption of benzonitrile derivatives on mild steel surface. The protection of carbon steel in 1 M HCl was confirmed by using scanning electron microscope (SEM) and Atomic Force Microscopy (AFM). Electrochemical, DFT and MD simulations results are in good agreement.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel benzonitrile derivatives have been synthesized and characterized. </LI> <LI> Potentiodynamic polarization curves reveal that tested inhibitors act as mixed type. </LI> <LI> The adsorption of two compounds obeys Langmuir adsorption isotherm. </LI> <LI> Surface morphology was examined by SEM and AFM. </LI> <LI> The experimental results were correlated with DFT and MD stimulation results. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>