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Genome-wide association studies approach and post-GWAS study in rice
Gang Li,Min-Young Yoon,Won-Hee Ra,Jae-Wan Park,Qiang He,Aye Aye Khaing,Xiao-Qiang Wang,Win Htet Oo,Feng-Peng Li,Byoung Kook Yun,Chang-Yong Lee,Yong-Jin Park 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
AGenome-wide association studies (GWAS) have proven a useful technique for identifying genetic loci responsible for natural variation in rice. With the fast developed next-generation sequencing technology, it is possible for people to carry out GWAS by phenotyping different traits. However, how to make full use of huge data, abandon unnecessary data, and solve the problem of data application effectively seems still an obstacle for many researchers. Taking the case of whole-genome resequencing of Korean authentic rice core set, here we present a general technological path of GWAS including: 1) a schematic view of sequencing-based GWAS in rice; 2) a user-friendly and interactive web application for GWAS in rice by the aid of experience from Arabidopsis; 3) Haplotype and association analysis of candidate genes in a certain mechanism pathway, giving 10 starch synthesis genes as example; and 4) functional validation by Trans- and Mata-Omics analysis.
율무한방차의 p-AMPK 발현증가에 의한 C57BL/6 마우스 간조직 지질축적 억제 효과
유강완(Gang Wan Yoo),박해진(Hae-Jin Park),조수정(Su-Jung Cho),이세희(Se Hui Lee),박순애(Soon-Ae Park),김미림(Mi-Lim Kim) 한국식품영양과학회 2022 한국식품영양과학회지 Vol.51 No.4
본 연구는 율무한방차의 간조직 지질대사 관련 단백질 발현 조절에 의한 지질축적 억제 작용을 알아보고자 하였다. C57BL/6 마우스를 4개군, 즉 Normal(정상식이군), Control(60% 고지방식이군), Control+가르시니아 캄보지아 200 mg/kg/d(GC군), Control+율무감비 열수추출물 200 mg/kg/d(YM200군)로 나누어 실험을 진행하였다. 실험 결과, 혈청 TG, TC 및 LDL-C 농도와 혈청 MDA 농도가 GC 및 YM200군에서 Control군보다 유의적으로 감소하였다. YM200 보충은 간조직 p-AMPK 발현을 증가시키고 간조직 지질합성에 주요한 역할을 하는 SREBP-2 및 HMGCR 단백질 발현을 감소시킨 반면, 간조직 지방산 산화 관련 단백질인 CPT-1 및 UCP-2 발현을 증가시킴으로써 간조직의 TG 및 TC 농도를 감소시키고 지방구 축적을 억제하는 결과를 나타내었다. 결론적으로 YM200은 간조직 p-AMPK 발현을 증가시켜 지질대사 관련 단백질 발현을 조절함으로써 간조직의 지질축적을 억제하였다. 따라서 YM200은 간조직 지질대사를 조절하고 지방간 제어에 효과적이라고 판단된다. The present study investigated the hepatic lipid-lowering effect of Yulmu herbal tea mediated by regulating hepatic protein expressions. C57BL/6 mice were randomly divided into four groups: (1) normal (normal diet), (2) control (60% high-fat diet), (3) control+Garcinia cambogia 200 mg/kg/d (GC), (4) control+Yulmugambi water extract 200 mg/kg/d (YM200). Serum triglyceride (TG), total cholesterol (TC), and low-density lipoprotein concentrations significantly decreased in the GC and YM200 groups compared to the control group. There was also a significant reduction in the serum malondialdehyde levels in the GC and YM200 groups. The YM200 treatment significantly increased the hepatic phosphorylated-AMP-activated protein kinase (p-AMPK) expression, and inhibited the hepatic sterol regulatory element-binding protein-2 and 3-hydroxy-3-methylglutaryl coenzyme A reductase protein expressions, which are the key regulators of hepatic lipid synthesis. YM200 also significantly upregulated hepatic fatty acid oxidation proteins such as carnitine palmitoyltransferase 1 and uncoupling protein 2. Therefore, hepatic TG and TC levels and lipid droplets were suppressed in the YM200 group. YM200 reduced hepatic lipid accumulation and regulated hepatic lipid-relating protein expressions mediated by upregulating the p-AMPK expression. In conclusion, YM200 may be useful for regulating hepatic lipid metabolism and hepatic steatosis.
Unio douglasiae (GAIFFITH et PIDGEON)의 生殖時期에 關한 組織學的 硏究
姜泰完 춘천교육대학교 과학교육연구소 1982 과학교육연구 Vol.8 No.-
In this study, the weight of gonads, the size of eggs and histological variation of the Unio douglasiae (GAIFFITH et PIDGEON) which inhabited in the Uiam lake, Gang Won Do, was investigated during the period from July 1980 to June 1981. 1. U. douglasiae is dioecious 2. The rate of biomass to total weight of gonads was 36.28∼36.61% in March and April, and 35.64∼36.08% in August and October. 3. Mean diameterof the eggs was 173.9∼171.5μ in March and April, and was 158.4∼151.9μ in August and October. And the shape of immature eggs are globe. 4. The gonad was filled with connective tissue and egg sac in March and April, in August and October. But connective tissue was gradually incresed and egg sac was constracted. 5. The spawning season of U. douglasiae was from April to July, and from October to December.
Extended Role-Based Access Control with Context-Based Role Filtering
( Gang Liu ),( Runnan Zhang ),( Bo Wan ),( Shaomin Ji ),( Yumin Tian ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.3
Activating appropriate roles for a session in the role-based access control (RBAC) model has become challenging because of the so-called role explosion. In this paper, factors and issues related to user-driven role management are analysed, and a session role activation (SRA) problem based on reasonable assumptions is proposed to describe the problem of such role management. To solve the SRA problem, we propose an extended RBAC model with context-based role filtering. When a session is created, context conditions are used to filter roles that do not need to be activated for the session. This significantly reduces the candidate roles that need to be reviewed by the user, and aids the user in rapidly activating the appropriate roles. Simulations are carried out, and the results show that the extended RBAC model is effective in filtering the roles that are unnecessary for a session by using predefined context conditions. The extended RBAC model is also implemented in the Apache Shiro framework, and the modifications to Shiro are described in detail.
Anodonta fucudai MODER 의 生殖細胞 形成 및 生殖時期에 關한 硏究
姜泰完 춘천교육대학교 과학교육연구소 1982 과학교육연구 Vol.9 No.-
In this study, the wight of gonads, the size of eggs and histological variation of the Anodonta fucudai MODER which inhabited in the Uiam lake, Gang Won Do, was investigated during the period from April 1981 to March 1982. 1. A. fucudai is dioecious. 2. The rate of biomass to total weight of gonads was 70.61% in August, and 47.98% in October. 3. The shape of immature eggs are globe. And the mean diameter of the eggs was gradually incresed from 176.0μ in August. 4. The gonad with connective tissue and egg sac in August. But connective tissue was gradually incresed and egg sac was constracted. 5. The spawing season of A. fucudai was from August to September.