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A Case of Epidermolysis Bullosa Simplex (Dowling-Meara 1 Type) in Newborn
Hong Gahyun,최민선 대한신생아학회 2022 Neonatal medicine Vol.29 No.4
Epidermolysis bullosa is a rare genetic skin disease in which skin easily peels off and blisters are formed with mild mechanical trauma. It is classified into simple, borderline, dysmorphic, and mixed type. These four subtypes are further classified according to the location of gene mutation and genetic patterns. Epidermolysis bullosa simplex (EBS) is characterized by separation in the epidermal or subepidermal layer. And it is mostly caused by mutation of keratin 5 (KRT5) and KRT14 genes. Recently, genetic test has become increasingly important for diagnosis, confirming subtypes and genetic counseling. And there are moderate correlation exists between the EBS phenotype and genotype. Here, we report a case of 2-day-old boy with EBS Dowling-Meara type (EBS-DM) diagnosed by mutation analysis in KRT14.
Lim Hee-Jin,Choi Gahyun,Hong KeeSuk 한국물리학회 2024 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.84 No.1
This study analyzed the optical techniques for high-resolution, low-noise spectroscopy of a hyperfne structure (HFS) made of ytterbium-isotope-171 ion (171Yb3+:Y2SiO5). Large energy spacings in 171Yb3+ are advantageous for spin-state preparations of quantum memory and construction of a transducer, thereby promoting the simultaneous stable control of the optical frequencies of lasers over a wide range of 3 GHz. We also built our own 2.7-K cryogenic system for optical, radio-waveassisted spectroscopy. We attained to high resolution and sensitivity both in pump–probe saturation spectroscopy (PPS) and Raman heterodyne spectroscopy (RHS). Our frequency-stabilized PPS achieved a high-resolution spectrum of the HFS, whereas our setup of RHS enabled the efcient detection of paramagnetic spin resonance efciently for a wide range of radio frequencies. As the underlying Raman process is an up-converting transduction, we present the optimization of the sensitivity of Raman heterodyne detections by selecting the best crystal orientation and efcient radio-wave coupling in future applications toward photon transducers.
최지원(Jiwon Choi),홍형진(Hyungjin Hong),이정섭(Jeongsub Lee),유주희(Juhee Yoo),박보람(Boram Park),김가현(Gahyun Kim),윤성원(Sungwon Yoon),이철민(Cheolmin Lee) 한국환경보건학회 2021 한국환경보건학회지 Vol.47 No.4
Background: This study was conducted to provide background information for the proper management of radon contamination in apartments using mechanical ventilation facilities in residential environments. Objectives: To this end, this study compared and evaluated changes in radon concentrations based on different operating intensities of mechanical ventilation with or without natural ventilation. Methods: For the continuous measurement of radon concentrations, an RAD7 instrument was installed in four apartments equipped with a ventilation system. The measurements were done for comparison of ventilation types and different ventilation intensities (“high”, “middle”, “low”). Results: The results confirmed that both mechanical and natural ventilation sufficiently reduced the radon concentration in the apartments. In particular, mechanical ventilation at “high” intensity was the most effective. Natural ventilation combined with mechanical ventilation and then natural ventilation alone were the second and the third most effective, respectively. Conclusions: When using ventilation to reduce indoor radon concentrations, it is most effective to operate mechanical ventilation (“high”) or natural ventilation and mechanical ventilation at the same time. In cases where mechanical ventilation is available alone, it is recommended to operate it at a minimum of “middle” intensity.