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Goda Thomas,Sánchez González Santiago 한국국제경제학회 2024 International Economic Journal Vol.38 No.1
Literature contends that the manufacturing sector is crucial for economic development, and it is conventional wisdom that exports drive manufacturing growth. However, it has yet to be established empirically whether the market size of export destinations is an essential factor in explaining diverging regional and sectoral manufacturing growth patterns. This article argues that accessing a few large external markets reduces entry costs, increases expectations of economies of scale, and fosters capital formation. To test this hypothesis, we construct a novel Relative Export Market Size (REMS) index that measures whether the share of sectoral exports destined to large economies in one region is higher than in other regions. Using a PVAR model with fixed effects, we verify the impact of the REMS index on value added, employment, and capital accumulation of 129 manufacturing sectors in 23 regions in Colombia from 1992 to 2017. The obtained results show that exporting to larger markets positively impacts employment, capital formation, and value added per capita of manufacturing sectors at a regional level. This finding indicates that exporting to the world’s largest market helps develop competitive manufacturing sectors.
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Goda, A.E.,Erikson, R.L.,Sakai, T.,Ahn, J.S.,Kim, B.Y. Elsevier BV 2015 MOLECULAR ONCOLOGY Vol.9 No.1
Novel combinations aiming at maximizing the efficacy of bortezomib are highly valued in the clinic. Therefore the current study investigated the outcomes of combining bortezomib with dipyridamole, a well-known antiplatelet. The co-treatment exerted a synergistic lethality in a panel of human leukemia/lymphoma cell lines of different origin. Mechanistically, dipyridamole did not modulate the proteasome inhibitory activity of bortezomib. However, dipyridamole triggered an endoplasmic reticulum (ER) stress, and co-treatment with bortezomib resulted in higher levels of ER stress than either monotherapies. Relieving ER stress with the protein translation inhibitor, cycloheximide suppressed cell death. Moreover, the enhanced ER stress by the co-treatment was associated with an aggravation of reactive oxygen species (ROS) generation and glutathione (GSH) depletion. Replenishing GSH pools significantly scavenged ROS and rescued the cells. Importantly, the cytotoxicity of the co-treatment was executed mainly via the mitochondrial apoptotic pathway with an efficient suppression of the key anti-apoptotic regulators, Mcl-1, Bcl-xl, Bcl-2 and XIAP, driving the independence of the co-treatment-induced apoptosis of a single apoptotic trigger. Furthermore, the intrinsic potential of bortezomib to inhibit important pro-survival pathways was enhanced by dipyridamole in a GSH/ROS-dependent manner. Interestingly, dipyridamole abrogated JAK2 phosphorylation indirectly and selectively in cancer cells, and the co-treatment-induced cytotoxicity was preserved in a model of stromal-mediated chemoresistance. In nude mice, the antitumor activity of the co-treatment surpassed that of bortezomib monotherapy despite that synergy was lacking. In summary, findings of the present study provided a preclinical rationale which warrants further clinical evaluation of bortezomib/dipyridamole novel combination in hematologic malignancies.
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Halloysite nanotubes based electrochemical sensors: A review
Goda, Emad S.,Gab-Allah, M.A.,Singu, Bal Sydulu,Yoon, Kuk Ro Elsevier 2019 Microchemical journal Vol.147 No.-
<P><B>Abstract</B></P> <P>Among the clays, halloysite nanotubes (HNTs) are fabulous hollow tubular type of aluminosilicates due to their interesting properties such as their natural occurrence, high surface area and cytocompatibility. Different ways of functionalization for the inner and surface of HNTs have been used to control their properties for specific applications. Moreover, the modified HNTs are considered a precious carrier for nanomaterials for improving their dispersion and can be designated for electrochemical sensing application due to their high surface area. The free lumen that was in HNTs can be utilized for hosting other compounds for obtaining nanostructures with excellent synergistic properties.</P> <P>The main purpose of this review is for the first time conducting a survey on the reports for engineering the HNTs surface to be used as an electrochemical sensor for identifying various analytes such as hydrogen peroxide, glucose, nitrite, ascorbic acid, surface plasmon resonance, catechol amines, hydrazine, dopamine and uric acid. Moreover, the latest procedures for the modification of HNTs with specified applications have been also described.</P> <P><B>Highlights</B></P> <P> <UL> <LI> HNTs are marvelous nanotubular materials which can be utilized for various applications. </LI> <LI> The inner and external surface of HNTs could show distinguished surface chemistry. </LI> <LI> HNTs can be modified using various for improving their properties for specified uses. </LI> <LI> The nanocomposites containing HNTs could be an efficient electrochemical sensor based on their properties. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Goda, A. E.,Erikson, R. L.,Ahn, J.-S.,Kim, B.-Y. Potamitis Press 2015 Anticancer research Vol.35 No.6
<P>Background/Aim: The current study investigated the mechanisms underlying the antitumor activity of SB265610, a cysteine-amino acid-cysteine (CXC) chemokines receptor 2 (CXCR2) antagonist. Materials and Methods: Cell-cycle progression and regulatory molecules were assessed by flow cytometry, immunoblotting, real-time PCR and immunoprecipitation. Target validation was achieved via RNA interference. Results: G(1) arrest induced by SB265610 occurred at concentrations lacking CXCR2 selectivity, persisted upon interleukin 8 (IL8) challenge, and did not affect IL8 downstream target expression. Profiling of G(1) regulators revealed cyclin-dependent kinase 2 (CDK2) (Thr160) hypophosphorylation, cyclin D3 gene downregulation, and p21 post-translational induction. However, only cyclin D3 and CDK2 contributed towards G(1) arrest. Furthermore, SB265610 induced a sustained phosphorylation of the p38MAPK. Pharmacological interference with p38MAPK significantly abrogated SB265610-induced G(1) arrest and normalized the expression of cyclin D3, with restoration of its exclusive binding to CDK6, but with weak recovery of CDK2 (Thr160) hypo-phosphorylation. Conclusion: The present study described the mechanisms for the anti-proliferative activity of SB265610 which may be of value in IL8-rich tumor microenvironments.</P>
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Halloysite nanotubes as smart flame retardant and economic reinforcing materials: A review
Goda, Emad. S.,Yoon, Kuk Ro,El-sayed, Shimaa H.,Hong, Sang Eun Elsevier 2018 Thermochimica acta Vol.669 No.-
<P><B>Abstract</B></P> <P>Halloysite nanotubes (HNTs) are precious clay materials with a hollow nanotubular structure. They are used up to date latent for synthesizing polymeric nanocomposite because of high surface area, low cost and the natural existence. HNTs nanocomposites have been fabricated using different methods; however, the widely used is melt mixing technique. The functionalization of HNTs is very crucial to achieve the well dispersion in polymer. The flammability, thermal stability and mechanical properties were improved by the addition of HNTs. Because of the tube shape of HNTs, it can help in trapping the flammable volatiles besides, HNTs can form a strong barrier on the surface of polymer against heat and mass transport processes. The essential aim of this review is the latest researches on modified halloysite nanotubes as an efficient flame retardant for various polymer nanocomposites and their influence on the mechanical properties and thermal stability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> HNTs are promising nanomaterials which have a tubular shape and can be designed for many applications. </LI> <LI> HNTs are used to prepare polymer nanocomposites using various methods. </LI> <LI> The functionalization of HNTs surface is very important for improving dispersion in polymer. </LI> <LI> Well dispersed HNTs in polymer can enhance the flammability, thermal stability and mechanical properties of polymer. </LI> <LI> HNTs can retard the flame using two commonly mechanisms (Condensed and gas phase). </LI> </UL> </P>
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Monodromy Maps of Fibered 2-Bridge Knots as Elements in Automorphism Groups of Free Groups
Goda, Hiroshi,Suzuki, Masaaki Department of Mathematics 2016 Kyungpook mathematical journal Vol.56 No.3
In this note, we study a monodromy map of a fibered 2-bridge knot. We show the monodromy map of a fibered 2-bridge knot as an element in the automorphism group of a free group.
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合田博子(GODA, Hiroko) 동북아시아문화학회 2013 동북아시아문화학회 국제학술대회 발표자료집 Vol.2013 No.5
The present reporter shows a new approach by which she rethinks ancient Japanese mythology from the environmental standpoints including resources and energy based upon the nature. This is the start point of environmental mythology as a part of environmental anthropology that she has studied for these 10 years. In this paper, she pays her attention to the cultural traits on whales, because she especially analyses a certain relation between Emperor Oujin’s name change ritual and a god relating the whales and a group of seamen and fishermen named Ochi clan navigating along the Black current and the Tsushima current.
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