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- 저자 : Fuqiang Hu (검색결과 5 건)
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Improved Antitumor Efficacy and Reduced Toxicity of Liposomes Containing Bufadienolides
Kaili Hu,Fuqiang Hu,Jianfang Feng,Lin Zhu,Haiyuan Liang 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.9
Long-circulating liposomes are used extensively nowadays for enhancing the therapeutic effect and reducing the toxicity of anticancer drugs. In this paper, a traditional Chinese medicine, toad venom, which has long been used in the clinic for tumor therapy with unpleasant side effects, was incorporated into poloxamer modified liposomes to increase its antitumor effect and reduce its toxicity. Our preparation of bufadienolides liposomes had a particle size of around 70 nm and an entrapment efficiency of about 87.6%. Lyophilized liposomes well retained their appearance, particle size and encapsulation efficiency for 3 months. The in vitro release results verified the sustained release properties of the bufadienolides liposomes. The concentration of bufadienolides in modified liposomes that caused 50% cell killing was much lower than that of free drug for both Lovo cells and NCI-H157 cells. Compared to the bufadienolides solution and the unmodified liposomes, the bufadienolides liposomes significantly prolonged the retention time and increased the area under the curve in vivo. The antitumor efficiency of the bufadienolides liposomes against mice bearing H22 liver cancer cells and Lewis pulmonary cancer cells were 2.15 and 2.96, respectively, times that of a bufadienolides solution at the same toxicity. The safety test results demonstrated that the bufadienolides liposomes had an LD_50 that was 3.5 times the LD_50 of bufadienolides solution and caused no allergen-related or blood vessel irritation effects. All these results proved that poloxamer modified bufadienolides liposomes have improved antitumor efficacy and safety.
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Huiru Zhao,Nana Li,Haoran Zhao,Fuqiang Li,Yuou Hu 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.2
The research on the relationship between electricity and economy of North China can make a contribution to the development of electric power industry policy. Based on the history data of electricity demand and economic growth from 1986 to 2010 in North China, the grey-relational theory is applied to determine the keyfactors influencing electricity demand. On this basis, the co-integration model and error correction model are employed to establish the relationship model between electricity demand and economic growth of North China. From the perspective of long-term equilibrium, when GDP increases 1%, total electricity consumption increases 0.8270%; when industrial added value of a share of GDP increases1%, total electricity consumption increases1.3011%; when electric power efficiency increases 1%, total electricity consumption increases by 4.5965%; when urbanization rate increases 1%, total electricity consumption increases3.0079%. Therefore, theelectric power efficiency is the main factor to promote the increase of electricity demand.
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A Novel Two-way Time Synchronization Protocol for Fusion Application
Yong Pang,Guangming Li,Xiaoming Wu,Fuqiang Wang,Yifan Hu,Qingchao Gong 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.8
Data fusion application is one of the most popular applications in Wireless sensor networks (WSNs). Time synchronization is an important technology for data fusion applications due to its necessary for data fusion in the networks. Aimed at reliable time synchronization performance, this paper proposes a novel two-way time synchronization protocol (NTSP). Combing node’s clock model and two-way packet exchange mechanism, NTSP makes time synchronization protocol more precise and much steadier. NTSP adopts simulated annealing (SA) algorithm to defend random noise and malicious delay attacks. Network simulations are carried out to analyze performances of NTSP on time synchronization accuracy, convergent rate and defensive degree for malicious delay attacks. Comparing to traditional time synchronization protocols, NTSP is an effective time synchronization protocol in WSNs.
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Research on Forecasting Electricity Demand of the 13th Five-year in Hebei Province
Huiru Zhao,Nana Li,Yaowen Fan,Fuqiang Li,Yuou Hu 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.11
With the emergence of a “new economic norm” and “industrial restructuring”, the electricity demand situation in Hebei province will undergo significant changes in the future. Therefore, it is essential to predict electricity demand in the 13th Five-year for power planning and construction. Considering the factors and mechanisms determining electricity demand of various sectors are different, the total electricity consumption in this paper is divided into five parts: the first industry, industry, construction, the tertiary industry and resident sectors. The electricity demand equations of different sectors are established to make predictions, respectively. The results show that the total electricity consumption will grow at an annual rate of 3.46%-3.87% during 13th Five-Year-Plan period, which would be more than 0.4234×1012 kWh in 2020. The electricity consumption growth of tertiary industry and resident sectors would raise fast, which will grow at an annual rate of 8.72%-9.15% and 6.24%-6.72% during 13th Five-Year-Plan period. Moreover, comparing with the demand structure in 13th Five-Year-Plan period, the proportion for industrial electricity demand will decline by 5%, the proportions for tertiary industry and resident sector will increase by 3% and 2%. The electricity consumption structure in Hebei province would change in the future.
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Jiao Li,Pingsheng Huang,Longlong Chang,Xingwen Long,Anjie Dong,Jinjian Liu,Liping Chu,Fuqiang Hu,Jianfeng Liu,Liandong Deng 한국고분자학회 2013 Macromolecular Research Vol.21 No.12
A new platform of paclitaxel (PTX) for application as an oral delivery system was developed, by combining the pH sensitivity of polyelectrolyte complex nanoparticles (CNPs) and the active targeting of hyaluronic acid (HA). Chitosan/hyaluronic acid-paclitaxel (CS/HA-PTX) CNPs were prepared by coating the CS onto the HA-PTX nanoparticles (NPs), and characterized by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1H NMR), transmission electron microscopy (TEM) and high-performance liquid chromatography (HPLC). HA-PTX conjugates could self-assemble into NPs in aqueous solution with an average size of 100±5 nm, and the PTX content of HA-PTX conjugates was 10.6 wt%. The CS/HA-PTX CNPs had a smaller size and higher PTX content when the ratio of positive charge to negative charge was 2:1. The in vitro release of PTX from CNPs was pH-responsive,suggesting that the CS shell could prevent the breakage of the ester bond in HA-PTX NPs in acidic pH conditions. HA-PTX NPs exhibited higher cellular uptake than free PTX against HepG2 cells via receptor-mediated endocytosis. PTX could accumulate remarkably into tumor sites after oral administration of CNPs. These results indicate that the CNP drug delivery system has great potential for applications in the oral administration of hydrophobic drugs.
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