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A parametric study of optimum tall piers for railway bridge viaducts
Martinez-Martin, Francisco J.,Gonzalez-Vidosa, Fernando,Hospitaler, Antonio,Yepes, Victor Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.6
This paper presents a parametric study of reinforced concrete bridge tall piers with hollow, rectangular sections. Such piers are typically used in railway construction of prestressed concrete viaducts. Twenty one different piers have been studied with seven column heights of 40, 50, 60, 70, 80, 90 and 100 m and three types of 10-span continuous viaducts, whose main span lengths are 40, 50 and 60 m. The piers studied are intermediate columns placed in the middle of the viaducts. The total number of optimization design variables varies from 139 for piers with column height of 40 m to 307 for piers with column height of 100 m. Further, the results presented are of much value for the preliminary design of the piers of prestressed concrete viaducts of high speed railway lines.
Evaluation of the Use of Guard Nodes for Securing the Routing in VANETs
Martinez, Juan A.,Vigueras, Daniel,Ros, Francisco J.,Ruiz, Pedro M. The Korea Institute of Information and Commucation 2013 Journal of communications and networks Vol.15 No.2
We address the problem of effective vehicular routing in hostile scenarios where malicious nodes intend to jeopardize the delivery of messages. Compromised vehicles can severely affect the performance of the network by a number of attacks, such as selectively dropping messages, manipulating them on the fly, and the likes. One of the best performing solutions that has been used in static wireless sensor networks to deal with these attacks is based on the concept of watchdog nodes (also known as guard nodes) that collaborate to continue the forwarding of data packets in case a malicious behavior in a neighbor node is detected. In this work, we consider the beacon-less routing algorithm for vehicular environments routing protocol, which has been previously shown to perform very well in vehicular networks, and analyze whether a similar solution would be feasible for vehicular environments. Our simulation results in an urban scenario show that watchdog nodes are able to avoid up to a 50% of packet drops across different network densities and for different number of attackers, without introducing a significant increase in terms of control overhead. However, the overall performance of the routing protocol is still far from optimal. Thus, in the case of vehicular networks, watchdog nodes alone are not able to completely alleviate these security threats.
MicroRNAs and periodontal disease: a qualitative systematic review of human studies
Mico-Martinez, Pablo,Alminana-Pastor, Pedro J.,Alpiste-Illueca, Francisco,Lopez-Roldan, Andres Korean Academy of Periodontology 2021 Journal of Periodontal & Implant Science Vol.51 No.-
Purpose: MicroRNAs (miRNAs) are epigenetic post-transcriptional regulators that modulate gene expression and have been identified as biomarkers for several diseases, including cancer. This study aimed to systematically review the relationship between miRNAs and periodontal disease in humans, and to evaluate the potential of miRNAs as diagnostic and prognostic biomarkers of disease. Methods: The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (reference number CRD42020180683). The MEDLINE, Scopus, Cochrane Library, Embase, Web of Science, and SciELO databases were searched for clinical studies conducted in humans investigating periodontal diseases and miRNAs. Expression levels of miRNAs across the different groups were analysed using the collected data. Results: A total of 1,299 references were identified in the initial literature search, and 23 articles were finally included in the review. The study designs were heterogeneous, which prevented a meta-analysis of the data. Most of the studies compared miRNA expression levels between patients with periodontitis and healthy controls. The most widely researched miRNA in periodontal diseases was miR-146a. Most studies reported higher expression levels of miR-146a in patients with periodontitis than in healthy controls. In addition, many studies also focused on identifying target genes of the differentially expressed miRNAs that were significantly related to periodontal inflammation. Conclusions: The results of the studies that we analysed are promising, but diagnostic tests are needed to confirm the use of miRNAs as biomarkers to monitor and aid in the early diagnosis of periodontitis in clinical practice.
Evaluation of the Use of Guard Nodes for Securing the Routing in VANETs
Juan A. Martinez,Daniel Vigueras,Francisco J. Ros,Pedro M. Ruiz 한국통신학회 2013 Journal of communications and networks Vol.15 No.2
We address the problem of effective vehicular routing in hostile scenarios where malicious nodes intend to jeopardize the delivery of messages. Compromised vehicles can severely affect the performance of the network by a number of attacks, such as selectively dropping messages, manipulating them on the fly, and the likes. One of the best performing solutions that has been used in static wireless sensor networks to deal with these attacks is based on the concept of watchdog nodes (also known as guard nodes) that collaborate to continue the forwarding of data packets in case a malicious behavior in a neighbor node is detected. In this work,we consider the beacon-less routing algorithm for vehicular environments routing protocol, which has been previously shown to perform very well in vehicular networks, and analyze whether a similar solution would be feasible for vehicular environments. Our simulation results in an urban scenario show that watchdog nodes are able to avoid up to a 50% of packet drops across different network densities and for different number of attackers, without introducing a significant increase in terms of control overhead. However, the overall performance of the routing protocol is still far from optimal. Thus, in the case of vehicular networks, watchdog nodes alone are not able to completely alleviate these security threats.
Shin, Taekyun,Carrillo-Salinas, Francisco J.,Martinez, Ana Feliu,Mecha, Miriam,Guaza, Carmen The Korean Society of Veterinary Science 2013 大韓獸醫學會誌 Vol.53 No.3
Galectin-3 is a ${\beta}$-galactoside-binding lectin that plays a role in neuroinflammation through cell migration, proliferation, and apoptosis. In the present study, regulation of galectin-3 was examined in the brain of mice infected with the Daniel strain of Theiler's murine encephalomyelitis virus (TMEV) at days 7 and 81 post-infection by immunohistochemistry. Immunohistochemistry revealed that galectin-3 was mainly localized in ionized calcium-binding adapter 1-positive macrophages/activated microglia, but not in Iba-1-positive ramified microglia. Galectin-3 was also weakly detected in some astrocytes in the same encephalitic lesions, but not in neurons and oligodendrocytes. Collectively, the present findings suggest that galectin-3, mainly produced by activated microglia/macrophages, may be involved in the pathogenesis of virus induced acute inflammation in the early stage as well as the chronic demyelinating lesions in Daniel strain of TMEV induced demyelination model.
Broadcast Message Dissemination Schemes for Urban Environments : a Survey
Julio A. Sanguesa,Manuel Fogue,Piedad Garrido,Francisco J. Martinez,Juan-Carlos Cano,Carlos T. Calafate 한국산업정보학회 2014 한국산업정보학회 학술대회논문집 Vol.2014 No.1
In VANKT traffic safety applications, efficient warning message dissemination is required. The main goal is to reduce the latency while ensuring the correct reception of warning information by nearby vehicles when a dangerous situation occurs. So far, several dissemination schemes have been proposed and evaluated under different conditions, and using different simulators, making it difficult to determine which is the optimal dissemination scheme. In this paper, we assess the performance of several existing broadcast dissemination schemes by evaluating them under the same conditions, and focusing on the same metrics, thus providing researchers with a general overview of the drawbacks and benefits associated to each scheme.