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Magnetic Resonance Myocardial Feature Tracking in Transfusion-Dependent Myelodysplastic Syndrome
Marta Alonso-Fernandez-Gatta,Ana Martin-Garcia,Maria Diez-Campelo,Agustin C. Martin-Garcia,Manuel Barreiro-Pérez,Félix Lopez-Cadenas,Elena Diaz-Pelaez,Pedro L. Sanchez 한국심초음파학회 2021 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.29 No.4
BACKGROUND: Myocardial deformation with echocardiography allows early detection of systolic dysfunction and is related to myocardial iron overload (MIO) determined by T2* in hereditary anemias under transfusion support. Our aim was to analyze the diagnostic and prognostic usefulness of magnetic resonance feature tracking (MR-FT) myocardial strain in low-risk myelodysplastic syndromes (LR-MDS) patients. METHODS: Prospective study in transfusion-dependent LR-MDS patients and healthy controls who underwent a cardiac MR-FT. We analyzed the relationships between strain MR-FT and iron overload parameters and its prognostic impact in cardiovascular events and/or death. RESULTS: Thirty-one patients and thirteen controls were included. MIO (T2* < 20 ms) was detected in 9.7% of patients. Left ventricular global longitudinal strain (LV-GLS) by MR-FT was pathological (> −19.3%) in 32.3% of patients. Less negative strain values correlated with lower T2* (R = −0.37, p = 0.033) and native myocardial T1 (R = −0.39, p = 0.031) times. LV-GLS by MR-FT was significantly associated with higher incidence of the combined cardiovascular events and/or all-cause death (p = 0.047), with a cut-off value of −17.7% for predicting them (63% sensitivity and 81% specificity, area under the curve = 0.69). After adjusting analysis including demographic, biomarkers and imaging variables, a higher LV-GLS value by MR-FT remained as predictor of combined event in transfusion-dependent LR-MDS patients (hazard ratio, 0.4; confidence interval, 0.15–0.98; p = 0.045). CONCLUSIONS: Longitudinal myocardial strain by MR-FT in LR-MDS patients is associated to MIO and correlates with adverse events in the follow-up, what could serve as a prognostic tool.
Fernandez, Juan C. Gutierrez,Garcia, Claudia I. The Honam Mathematical Society 2016 호남수학학술지 Vol.38 No.2
In a paper of S. H. Choi [2], the author studied the derivations of a restricted Weyl Type non-associative algebra, and determined a 1-dimensional vector space of derivations. We describe all the derivations of this algebra and prove that they form a 3-dimensional Lie algebra.
Fernandez, Maria Elena,Goszczynski, Daniel Estanislao,Prando, Alberto Jose,Peral-Garcia, Pilar,Baldo, Andres,Giovambattista, Guillermo,Liron, Juan Pedro Korean Society of Animal Sciences and Technology 2014 한국축산학회지 Vol.56 No.5
Puberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertal bulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexual development and spermatogenic function. The objective of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) located in thyroglobulin(TG) gene with age of puberty in Angus bulls. Four SNPs were genotyped in 273 animals using SEQUENOM technology and the association between markers and puberty age was analyzed. Results showed a significant association (P < 0.05) between these markers and puberty age estimated at a sperm concentration of 50 million and a progressive motility of 10%. This is the first report of an association of TG polymorphisms with age of puberty in bulls, and results suggest the importance of thyroidal regulation in bovine sexual development and arrival to puberty.
Ponce-Garcia, Gustavo,Villanueva-Segura, Olga K.,Garza-Elizondo, Karina,Villegas-Ramirez, Heriberto M.,Fernandez-Salas, Ildefonso,Rodriguez-Sanchez, Iram P.,Dzul-Manzanilla, Felipe,Flores-Suarez, Adri The Korea Society for Parasitology and Tropical Me 2022 The Korean Journal of Parasitology Vol.60 No.3
The head louse Pediculus humanus capitis (De Geer) is a hematophagous ectoparasite that inhabits the human scalp. The infestations are asymptomatic; however, skin irritation from scratching occasionally may cause secondary bacterial infections. The present study determined the presence and frequency of the knockdown resistance (kdr) mutation T929I in 245 head lice collected from Mexico, Peru, and Canada. Head lice were collected manually using a comb in the private head lice control clinic. Allele mutation at T9291 was present in 100% of the total sampled populations (245 lice) examined. In addition, 4.89% of the lice were homozygous susceptible, whereas 6.93% heterozygous and 88.16% homozygous were resistant, respectively. This represents the second report in Mexico and Quebec and fist in Lima.
C. Garcia‑Cabezon,M. A. Castro‑Sastre,A. I. Fernandez‑Abia,M. L. Rodriguez‑Mendez,F. Martin‑Pedrosa 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.11
The 17–4 Precipitation Hardening Stainless Steel (PH SS) manufactured by Selective Laser Melting (SLM) has wide applicationperspectives, but they are limited due to defects and anisotropy. The selection of the appropriate process variablesplays a fundamental part in the microstructure and in the determination of the final mechanical and corrosion properties. The main purpose of this study is to analyze the corrosion behavior, hardness and microstructure of 17–4 PH SS manufacturedby SLM in comparison to the commercial counterparts. The anisotropic behavior was investigated by analyzing themicrostructure–hardness and corrosion interrelationship, both in the surface of the construction platform and in the growthdirection of the element. The corrosion behavior of the SLM 17–4PH SS in its natural state was investigated in relation tothat of the 17–4 PH SS heat treated in a 0.1 M NaCl + 0.5 M H2SO4solution, using three electrochemical techniques. Theresults confirmed that the corrosion resistance of SLM 17–4 PH SS was considerably better than that of the forging, evenafter 60 days of immersion in the test solution. This was attributed to the absence of important manufacturing defects, tothe fine microstructure with an important amount of austenite produced by SLM, and to a small amount of non-metallicinclusions precipitated as a result of the fast cooling and the high speed of solidification associated with the SLM process.
Contrast Harmonic Endoscopic Ultrasound in Pancreatic Diseases
Rafael Mejuto-Fernandez,Julio Iglesias-Garcia 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.3
Endoscopic ultrasound (EUS) was first described in 1986, with the aim of overcoming the problems affecting transabdominalultrasound imaging, mainly problems related to the interposition of gas, and artifacts produced by bone or fat. Now, EUS can beconsidered as the best method for the analysis of pancreatic diseases, overtaking the diagnostic accuracy of computed tomographyand magnetic resonance imaging. However, fundamental B-mode imaging is limited for the diagnosis of solid pancreatic lesions,because most of them are depicted as heterogeneous and hypo-echoic, and it is difficult to differentiate between benign andmalignant lesions. Similar to how perfusion patterns obtained by computed tomography or magnetic resonance imaging afterinjection of contrast agents allow for the characterization of focal lesions, EUS has also recently been introduced to the use of contrastagents for performing contrast-enhanced harmonic EUS (CEH-EUS), which has the capability to distinguish the type of perfusionbetween lesions and surrounding tissue. CEH-EUS has shown its usefulness for the diagnosis and characterization of solid pancreaticlesions. Moreover, CEH-EUS is also highly accurate for distinguishing non-neoplastic from neoplastic cysts in pancreatic lesions. Another potential role of CEH-EUS is its ability to direct EUS-guided tissue acquisition.
( Maria Elena Fernandez ),( Daniel Estanislao Goszczynski ),( Alberto Jose Prando ),( Pilar Peral Garcia ),( Andres Baldo ),( Guillermo Giovambattista ),( Juan Pedro Liron ) 한국동물자원과학회(구 한국축산학회) 2014 한국축산학회지 Vol.56 No.17
Puberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertalbulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexualdevelopment and spermatogenic function. The objective of this study was to evaluate the association betweensingle nucleotide polymorphisms (SNPs) located in thyroglobulin(TG) gene with age of puberty in Angus bulls. FourSNPs were genotyped in 273 animals using SEQUENOM technology and the association between markers andpuberty age was analyzed. Results showed a significant association (P < 0.05) between these markers and pubertyage estimated at a sperm concentration of 50 million and a progressive motility of 10%. This is the first report of anassociation of TG polymorphisms with age of puberty in bulls, and results suggest the importance of thyroidalregulation in bovine sexual development and arrival to puberty.
( Juan C. Gutierrez Fernandez ),( Claudia I. Garcia ) 호남수학회 2016 호남수학학술지 Vol.38 No.2
In a paper of S. H. Choi [2], the author studied the derivations of a restricted Weyl Type non-associative algebra, and determined a 1-dimensional vector space of derivations. We de- scribe all the derivations of this algebra and prove that they form a 3-dimensional Lie algebra.
Trichuris vulpis (Froelich, 1789) Infection in a Child: A Case Report
Adrian Marquez-Navarro,Gudelio Garcia-Bracamontes,Blanca E. Alvarez-Fernandez,Luz P. Avila-Caballero,Isabel Santos-Aranda,Dylan L. Diaz-Chiguer,Rosa M. Sanchez-Manzano,Elvia Rodriguez-Bataz,Benjamin N 대한기생충학열대의학회 2012 The Korean Journal of Parasitology Vol.50 No.1