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      • KCI등재

        Un siglo de humor en La columna periodistica de autores gallegos: hacia una columna Ludica de autor y personaje

        ( Carlos Fernandez Gonzalez ) 한국스페인어문학회(구 한국서어서문학회) 2011 스페인어문학 Vol.0 No.61

        El proposito de este articulo es analizar el humor como recurso estilistico, retorico y narrativo (es decir, literario) en la columna periodistica. Para ello, se ha seleccionado a cuatro autores gallegos que cubren un periodo temporal cercano a un siglo, el transcurrido desde principios del siglo XX hasta la actualidad: Julio Camba, Ricardo Outeirino, Wenceslao Fernandez Florez y Manuel Jabois. Mas en concreto, el presente trabajo pretende examinar los resortes empleados por estos autores para presentar a sus lectores informacion, analisis y opinion en clave humoristica, asi como los diferentes grados de protagonismo del autor como personaje. Se procura definir, al mismo tiempo, la evolucion general experimentada por el genero proteico denominado columna (desde un esquema basico facilmente reconocible: informacion-opinion-humor) y su tendencia actual hacia lo que se propone denominar columna ludica, que otorga al humor relevancia definitiva y encuentra especificidad, ademas, en la presentacion indisimulada de su autor como personaje protagonista. Para todo ello, se opta por una aproximacion teorica transversal y eclectica, integradora, articulada en torno a ideas, conceptos y propuestas para el analisis proporcionados por la teoria de los generos literarios y de los generos periodisticos, la narratologia, la retorica y el analisis del discurso.

      • SCIESCOPUSKCI등재

        Hyaluronic acid reduces inflammation and crevicular fluid IL-1β concentrations in peri-implantitis: a randomized controlled clinical trial

        Sanchez-Fernandez, Elena,Magan-Fernandez, Antonio,O'Valle, Francisco,Bravo, Manuel,Mesa, Francisco Korean Academy of Periodontology 2020 Journal of Periodontal & Implant Science Vol.50 No.-

        Purpose: This study investigated the effects of hyaluronic acid (HA) on peri-implant clinical variables and crevicular concentrations of the proinflammatory biomarkers interleukin (IL)-1β and tumor necrosis factor (TNF)-α in patients with peri-implantitis. Methods: A randomized controlled trial was conducted in peri-implantitis patients. Patients were randomized to receive a 0.8% HA gel (test group), an excipient-based gel (control group 1), or no gel (control group 2). Clinical periodontal variables and marginal bone loss after 0, 45, and 90 days of treatment were assessed. IL-1β and TNF-α levels in crevicular fluid were measured by enzyme-linked immunosorbent assays at baseline and after 45 days of treatment. Clustering analysis was performed, considering the possibility of multiple implants in a single patient. Results: Sixty-one patients with 100 dental implants were assigned to the test group, control group 1, or control group 2. Probing pocket depth (PPD) was significantly lower in the test group than in both control groups at 45 days (control 1: 95% CI, -1.66, -0.40 mm; control 2: 95% CI, -1.07, -0.01 mm) and 90 days (control 1: 95% CI, -1.72, -0.54 mm; control 2: 95% CI, -1.13, -0.15 mm). There was a trend towards less bleeding on probing in the test group than in control group 2 at 90 days (P=0.07). Implants with a PPD ≥5 mm showed higher levels of IL-1β in the control group 2 at 45 days than in the test group (P=0.04). Conclusions: This study demonstrates for the first time that the topical application of a HA gel in the peri-implant pocket and around implants with peri-implantitis may reduce inflammation and crevicular fluid IL-1β levels.

      • Identification of duck IL-4 and its inhibitory effect on IL-17A expression in <i>R. anatipestifer-</i>stimulated splenic lymphocytes

        Fernandez, Cherry P.,Afrin, Fahmida,Flores, Rochelle A.,Kim, Woo H.,Jeong, Jipseol,Kim, Suk,Lillehoj, Hyun S.,Min, Wongi Elsevier 2018 Molecular immunology Vol.95 No.-

        <P>As the dysregulation of IL-17 is implicated in the pathogenesis of various autoimmune and inflammatory diseases, the suppression of IL-17 production by Th2 cytokines could alleviate the development of these diseases. Previously, we confirmed that inflammatory cytokines including IL-17A are strongly associated with R. anatipestifer infection, which is one of the most important bacterial pathogens in the duck industry. Here, we found that IL-4 treatment downregulated the expression of IL-17A and IL-17F transcripts in splenic lymphocytes stimulated with R. anatipestifer. Moreover, duck IL-4 (duIL-4) treatment in R. anatipestifer-stimulated lymphocytes suppressed the expression of IL-23p19 and IL-12p40 transcripts compared to untreated and stimulated lymphocytes. Conversely, dulL-4 increased levels of IFN-gamma and IL-10. We identified a full-length dulL-4 cDNA encoding 136 amino acids from ConA-activated splenic lymphocytes that shares 49.3-50% amino acid sequence identity with chicken and quail IL-4 and 21-29.7% with mammalian and piscine homologues. Low or moderate levels of dulL-4 transcript were observed in healthy tissues, including the spleen, bursa, and thymus, whereas dulL-4 expression was higher in the kidney and lung. Levels of dulL-4 were generally upregulated in mitogen-activated splenic lymphocytes but lower in the liver and spleen of R. anatipestifer-infected ducks compared to those of infected chickens. Recombinant dulL-4 promoted nitric oxide synthesis in duck macrophages stimulated by It anatipestifer compared to untreated and stimulated control macrophages. These results demonstrate that IL-4 is an important Th2 cytokine that inhibits inflammatory responses in splenic lymphocytes stimulated with R. anatipestifer.</P>

      • KCI등재

        A Conserved Motif Controls Nuclear Localization of Drosophila Muscleblind

        Fernandez-Costa, Juan M.,Artero, Ruben Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.1

        Human Muscleblind-like proteins are alternative splicing regulators that are functionally altered in the RNA-mediated disease myotonic dystrophy. There are different Muscleblind protein isoforms in Drosophila and we previously determined that these have different subcellular localizations in the COS-M6 cell line. Here, we describe the conservation of the sequence motif KRAEK in isoforms C and E and propose a specific function for this motif. Different Muscleblind isoforms localize to the peri-plasma membrane (MblA), cytoplasm (MblB), or show no preference for the nuclear or cytoplasmic compartment (MblC and MblD) in Drosophila S2 cells transiently transfected with Musclebind expression plasmids. Mutation of the KRAEK motif reduces MblC nuclear localization, whereas fusion of a single KRAEK motif to the heterologous protein ${\beta}$-galactosidase is sufficient to target the reporter protein to the nucleus of S2 cells. This motif is not exclusive to Muscleblind proteins and is detected in several other protein types. Taken together, these results suggest that the KRAEK motif regulates nuclear translocation of Muscleblind and may constitute a new class of nuclear localization signal.

      • KCI등재후보

        Understanding Current Issues in Research and Education in Science and Technology: A Framework of Knowledge and Action Sharing between Universities and Science and Technology Parks

        Fernandez, Ramon Emilio,Ferguson, David L. World Technopolis Association 2017 World Technopolis Review Vol.6 No.1

        Humanity is experiencing a very fast-paced technological evolution. As technological systems evolve exponentially, societies are becoming more global and are starting to have impacts beyond their geographic demarcations. This implies that, the actions of a person who is across the ocean from where we live could have significant impacts on our everyday lives. This article explores the complexity of globalization, identifies a number of global issues, and looks at the University and the Science and Technology Parks as potential sources of human capital to tackle current and forthcoming global challenges, ranging from new energy sources to potable water distributions. The article focuses on current efforts that are taking place across universities and science and technology parks around the world. We propose a new methodology whereby interdisciplinary work can inform the development of multidisciplinary approaches to solve some of the most complex global issues such as cyber security and educating the next generations of global leaders, providing them them with the necessary skills to be successful in a globally distributed workforce.

      • KCI등재

        A NOTE ON A WEYL-TYPE ALGEBRA

        Fernandez, Juan C. Gutierrez,Garcia, Claudia I. The Honam Mathematical Society 2016 호남수학학술지 Vol.38 No.2

        In a paper of S. H. Choi [2], the author studied the derivations of a restricted Weyl Type non-associative algebra, and determined a 1-dimensional vector space of derivations. We describe all the derivations of this algebra and prove that they form a 3-dimensional Lie algebra.

      • SCIESCOPUSKCI등재

        Low HDL cholesterol is associated with increased atherogenic lipoproteins and insulin resistance in women classified with metabolic syndrome

        Fernandez, Maria Luz,Jones, Jennifer J.,Ackerman, Daniela,Barona, Jacqueline,Calle, Mariana,Comperatore, Michael V.,Kim, Jung-Eun,Andersen, Catherine,Leite, Jose O.,Volek, Jeff S.,McIntosh, Mark,Kalyn The Korean Nutrition Society 2010 Nutrition Research and Practice Vol. No.

        Both metabolic syndrome (MetS) and elevated LDL cholesterol (LDL-C) increase the risk for cardiovascular disease (CVD). We hypothesized that low HDL cholesterol (HDL-C) would further increase CVD risk in women having both conditions. To assess this, we recruited 89 women with MetS (25-72 y) and LDL-C ${\geq}$ 2.6 mmol/L. To determine whether plasma HDL-C concentrations were associated with dietary components, circulating atherogenic particles, and other risk factors for CVD, we divided the subjects into two groups: high HDL-C (H-HDL) (${\geq}$ 1.3 mmol/L, n=32) and low HDL-C (L-HDL) (< 1.3 mmol/L, n=57). Plasma lipids, insulin, adiponectin, apolipoproteins, oxidized LDL, Lipoprotein(a), and lipoprotein size and subfractions were measured, and 3-d dietary records were used to assess macronutrient intake. Women with L-HDL had higher sugar intake and glycemic load (P< 0.05), higher plasma insulin (P< 0.01), lower adiponectin (P< 0.05), and higher numbers of atherogenic lipoproteins such as large VLDL (P < 0.01) and small LDL (P<0.001) than the H-HDL group. Women with L-HDL also had larger VLDL and both smaller LDL and HDL particle diameters (P<0.001). HDL-C was positively correlated with LDL size (r=0.691, P<0.0001) and HDL size (r=0.606, P<0.001), and inversely correlated with VLDL size (r=-0.327, P<0.01). We concluded that L-HDL could be used as a marker for increased numbers of circulating atherogenic lipoproteins as well as increased insulin resistance in women who are already at risk for CVD.

      • Ascent - Challenges and Advances of Tall Mass Timber Construction

        Fernandez, Alejandro,Komp, Jordan,Peronto, John Council on Tall Building and Urban Habitat Korea 2020 International journal of high-rise buildings Vol.9 No.3

        Ascent, a 25 story residential tower located in Milwaukee, WI (USA), will become the tallest timber building in the world upon completion. This paper discusses the project's structural system, permit process, groundbreaking project specific testing, and several of the challenges the team overcame, all of which open the door to future Mass Timber projects; particularly in the United States.

      • SCOPUSKCI등재

        Explaining the Drift Behavior of Caffeine and Glucosamine After Addition of Ethyl Lactate in the Buffer Gas of an Ion Mobility Spectrometer

        Fernandez-Maestre, Roberto,Velasco, Andres Reyes,Hill, Herbert H. Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.4

        Protonated caffeine ($CH^+$) and glucosamine ($GH^+$) overlapped in an analysis with ion mobility spectrometryquadrupole mass spectrometry. Ethyl lactate vapor (L) at different concentrations from 0 to 22 mmol $m^{-3}$ was added as a buffer gas modifier to separate these signals. The drift times of $CH^+$ and $GH^+$ increased with L concentration. The drift time increase was associated to clustering equilibria of $CH^+$ and $GH^+$ with one molecule of L and the equilibrium of $GH^+$ was more displaced to the formation of $GLH^+$ than that of $GLH^+$. $GH^+$ clustered more to L than $CH^+$ because $GLH^+$ formed more stable hydrogen bonds (26.30 kcal/mol) than $GLH^+$ (24.66 kcal/mol) and the positive charge in $GH^+$ was more sterically accessible than in $CH^+$. The aim of this work was to use theoretical calculations to guide the selection of a buffer gas modifier for IMS separations of two compounds that overlap in the mobility spectra and predict this separation, simplifying that empirical process.

      • SCISCIESCOPUS

        Permanent Magnet Temperature Estimation in PM Synchronous Motors Using Low-Cost Hall Effect Sensors

        Fernandez, Daniel,Hyun, Doosoo,Park, Yonghyun,Reigosa, David Diaz,Lee, Sang Bin,Lee, Dong-Myung,Briz, Fernando [Institute of Electrical and Electronic Engineers] 2017 IEEE transactions on industry applications Vol.53 No.5

        <P>Knowledge of the permanent magnet (PM) temperature in PM synchronous machines (PMSMs) is of great importance both for control and monitoring purposes. Increase in PM temperature during motor operation can degrade the magnetic flux strength and consequently the machine's torque production capability, and can also cause irreversible demagnetization of the PM. Direct measurement of the PM temperature is not viable in practice due to both cost and reliability issues. Indirect PM temperature estimation methods recently studied require knowledge of thermal or electrical model parameters or can have undesired effects on motor operation. In this paper, the feasibility of using low-cost Hall-effect sensors for PM temperature estimation is investigated. Hall sensors are present for detecting the initial position of the rotor in majority of PMSM applications for which incremental encoders are used for control. The proposed method can, therefore, be implemented with low or no additional cost. Experimental results on two interior PMSMs show that the method is capable of providing noninvasive estimation of the PM temperature without a priori motor parameter information for monitoring and protection against excessive increase in temperature.</P>

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