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Frost Damage Improvement for Railway Subgrade Based on Ground Temperature Control in Cold Regions
Junyun Zhang,Zhuoling He,Jun Feng 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.8
Due to the ignorance of the influence of frozen soil during the design period, the frost damage of subgrade in Datong-Junggar Railway was serious. The improvement scheme of frost damage was researched. However, the research based on the existing project was few, and previous improvement schemes could have an impact on the normal operation of railway system. Datong-Junggar Railway has undertaken the important task of transporting coal resources for China since its normal operation. To ensure normal operation of existing railway, the heating hole scheme was investigated by finite element simulations. The embedding spacing, the heating hole temperature and the embedding depth were analyzed. Based on the simulated results and on-site conditions, the design scheme of the heating hole (embedding spacing: 1.0 m, the heating hole temperature: 30°C and embedding depth: 70 cm) was proposed. Finally, the on-site monitoring in Qianshimen was taken to verify the feasibility of the heating hole scheme. Under the continuous energizing condition, the ground temperature remained basically stable even though the temperature had dropped to -7oC. The research results could enrich the design schemes for frost damage in cold regions from the aspect of ground temperature control.
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Fu Shangfeng,Zhang Hongyan,Li Xiancai,Zhang Qiling,Guo Chunyan,Qiu Keqing,Feng Junyun,Liu Xiaoxiao,Liu Dewu 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.2
BACKGROUND: Diabetic wound healing remains a major challenge due to the impaired functionality of angiogenesis by persistent hyperglycemia. Mesenchymal stem cell exosomes are appropriate candidates for regulating the formation of angiogenesis in tissue repair and regeneration. Here, we explored the effects of exosomes derived from human amniotic mesenchymal stem cell (hAMSC-Exos) on the biological activities of human umbilical vein endothelial cells (HUVECs) treated with high glucose and on diabetic wound healing and investigate lncRNAs related to angiogenesis in hAMSC-Exos. METHODS: hAMSCs and hAMSC-Exos were isolated and identified by flow cytometry or western blot. A series of functional assays such as cell counting kit-8, scratching, transwell and tube formation assays were performed to evaluate the potential effect of hAMSC-Exos on high glucose-treated HUVECs. The effect of hAMSC-Exos on diabetic wound healing were tested by measuring wound closure rates and immunohistochemical staining of CD31. Subsequently, the lncRNAs profiles in hAMSC-Exos and hAMSCs were examined to screen the lncRNAs related to angiogenesis. RESULTS: The isolated hAMSC-Exos had a size range of 30–150 nm and were positive for CD9, CD63 and CD81. The hAMSC-Exos facilitate the functional properties of high glucose-treated HUVECs including the proliferation, migration and the angiogenic activities as well as wound closure and angiogenesis in diabetic wound. hAMSC-Exos were enriched lncRNAs that related to angiogenesis, including PANTR1, H19, OIP5-AS1 and NR2F1-AS1. CONCLUSION: Our findings demonstrated hAMSC-Exos facilitate diabetic wound healing by angiogenesis and contain several exosomal lncRNAs related to angiogenesis, which may represent a promising strategy for diabetic wound healing.
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