Covalent Confinement of Sulfur Copolymers onto Graphene Sheets Affords Ultrastable Lithium-Sulfur Batteries with Fast Cathode Kinetics

Ma, Junpeng,Fan, Jingbiao,Chen, Shang,Yang, Xinyue,Hui, Kwun Nam,Zhang, Hongwen,Bielawski, Christopher W.,Geng, Jianxin American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.14

<P>Lithium-sulfur (Li-S) batteries have received significant attention due to the high theoretical specific capacity of sulfur (1675 mA h g<SUP>-1</SUP>). However, the practical applications are often handicapped by sluggish electrochemical kinetics and the “shuttle effect” of electrochemical intermediate polysulfides. Herein, we propose an in-situ copolymerization strategy for covalently confining a sulfur-containing copolymer onto reduced graphene oxide (RGO) to overcome the aforementioned challenges. The copolymerization was performed by heating elemental sulfur and isopropenylphenyl-functionalized RGO to afford a sulfur-containing copolymer, that is, RGO-<I>g</I>-poly(S-<I>r</I>-IDBI), which is featured by a high sulfur content and uniform distribution of the poly(S-<I>r</I>-IDBI) on RGO sheets. The covalent confinement of poly(S-<I>r</I>-IDBI) onto RGO sheets not only enhances the Li<SUP>+</SUP> diffusion coefficients by nearly 1 order of magnitude, but also improves the mechanical properties of the cathodes and suppresses the shuttle effect of polysulfides. As a result, the RGO-<I>g</I>-poly(S-<I>r</I>-IDBI) cathode exhibits an enhanced sulfur utilization rate (10% higher than that of an elemental sulfur cathode at 0.1C), an improved rate capacity (688 mA h g<SUP>-1</SUP> for the RGO-<I>g</I>-poly(S-<I>r</I>-IDBI) cathode vs 400 mA h g<SUP>-1</SUP> for an elemental sulfur cathode at 1C), and a high cycling stability (a capacity decay of 0.021% per cycle, less than one-tenth of that measured for an elemental sulfur cathode).</P> [FIG OMISSION]</BR>

Use of condensed molasses fermentation solubles as an alternative source of concentrates in dairy cows

Ma, Jian,Ma, Chen,Fan, Xue,Shah, Ali Mujtaba,Mao, Jiang Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.2

Objective: The purpose of present study was to investigate the effects of condensed molasses fermentation solubles (CMS) on lactation performance, rumen fermentation, nutrient digestibility, and serum parameters of dairy cows. Methods: A total of 75 healthy Holstein cows with the same parity (milk production = 35±2.5 kg, body weight = 570±28 kg) were randomly selected and divided into 5 groups. One group served as control group (CON; no CMS), whereas the other 4 groups were CMS1 (accounted for 1% of the diet), CMS2 (2%), CMS3 (3%), and CMS4 (4%). All cows were fed regularly three times each day at 0800, 1600, and 2400 h. Cows received diet and water ad libitum. The experiment lasted for 60 days. Results: Results showed that the dry matter intake, milk yield, and protein of CMS2 were maximum and higher (p<0.05) than CMS4. The ruminal pH was observed less than 6 in CMS3 and CMS4 groups. No noticeable difference of microbial protein was found between CON and CMS2 groups, while the microbial protein in these groups was higher (p<0.05) than CMS3 and CMS4 groups. The apparent digestibility of dry matter, organic matter, and crude protein in CMS2 group was higher (p<0.05) than CMS3 and CMS4 groups. Compared to CMS3 and CMS4 groups, the CMS2 group increased (p<0.05) the serum concentrations of immunoglobulin G and immunoglobulin M on d 60. Conclusion: Therefore, it is practicable that CMS substitutes for a part of concentrates in lactating cows' diets, but higher addition of CMS (more than 3% of the diet) could decrease production performance of dairy cows as seen in the present study.

Comparison of Microbial Diversity and Composition in the Jejunum and Colon of Alcohol-Dependent Rats

( Yang Fan ),( Zhao Ya-e ),( Wei Ji-dong ),( Lu Yu-fan ),( Zhang Ying ),( Sun Ya-lun ),( Ma Meng-yu ),( Zhang Rui-ling ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.11

Alcohol dependence is a global public health problem, yet the mechanisms of alcohol dependence are incompletely understood. The traditional view has been that ethanol alters various neurotransmitters and their receptors in the brain and causes the addiction. However, an increasing amount of experimental evidence suggests that gut microbiota also influence brain functions via gut-to-brain interactions, and may therefore induce the development of alcohol use disorders. In this study, a rat model of alcohol dependence and withdrawal was employed, the gut microbiota composition was analyzed by high-throughput 16S rRNA gene sequencing, and the metagenome function was predicted by PICRUSt software. The results suggested that chronic alcohol consumption did not significantly alter the diversity and richness of gut microbiota in the jejunum and colon, but rather markedly changed the microbiota composition structure in the colon. The phyla Bacteroidetes and eight genera including Bacteroidales S24-7, Ruminococcaceae, Parabacteroides, Butyricimonas, et al were drastically increased, however the genus Lactobacillus and gauvreauii in the colon were significantly decreased in the alcohol dependence group compared with the withdrawal and control groups. The microbial functional prediction analysis revealed that the proportions of amino acid metabolism, polyketide sugar unit biosynthesis and peroxisome were significantly increased in the AD group. This study demonstrated that chronic alcohol consumption has a dramatic effect on the microbiota composition structure in the colon but few effects on the jejunum. Inducement of colonic microbiota dysbiosis due to alcohol abuse seems to be a factor of alcohol dependence, which suggests that modulating colonic microbiota composition might be a potentially new target for treating alcohol addiction.

MnOx Nanowires@MnOx Nanosheets Core–Shell Heterostructure Electrode for Superior Performance in Supercapacitor

Zhipeng Ma,Fengyang Jing,Liyin Hou,Lukai Fan,Yao Zhao,Yuqian Fan,Xiujuan Qin 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2020 NANO Vol.15 No.03

Manganese-based oxides are one of the most promising high-performance supercapacitor (SC) electrode materials. In this work, a stable MnOx nanowires@MnOx nanosheets core–shell heterostructure electrode material consisting of MnOx nanosheets grown uniformly on the surface of MnOx nanowires has been prepared by a simple liquid phase method followed by thermal treatment. The electrode displays a specific capacity of 336 F g -1 at 1 A g -1 and exhibits a good cycling life of 83% capacitance retention after 5000 cycles. This is mainly due to the synergy effect between the one-dimensional MnOx nanowires as the backbone structure and the two-dimensional MnOx nanosheets with large specific surface area provide more active sites and the rapid transmission of electrons.

CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin

Jingbo Ma,Xiaolong Xu,Chunjin Fu,Peng Xia,Ming Tian,Liuhai Zheng,Kun Chen,Xiaolian Liu,Yilei Li,Le Yu,Qinchang Zhu,Yangyang Yu,Rongrong Fan,Haibo Jiang,Zhifen Li,Chuanbin Yang,Chengchao Xu,Ying Long,J 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades. Cadherin 17 (CDH17) is a membrane protein highly expressed in cancers of digestive system. Nanobody represents a novel antibody format for cancer targeted imaging and drug delivery. Nanobody targeting CHD17 as an imaging probe and a delivery vehicle of toxin remains to be explored for its theragnostic potential in gastric cancer. Methods: Naïve nanobody phage library was screened against CDH17 Domain 1-3 and identified nanobodies were extensively characterized with various assays. Nanobodies labeled with imaging probe were tested in vitro and in vivo for gastric cancer detection. A CDH17 Nanobody fused with toxin PE38 was evaluated for gastric cancer inhibition in vitro and in vivo. Results: Two nanobodies (A1 and E8) against human CDH17 with high affinity and high specificity were successfully obtained. These nanobodies could specifically bind to CDH17 protein and CDH17-positive gastric cancer cells. E8 nanobody as a lead was extensively determined for tumor imaging and drug delivery. It could efficiently co-localize with CDH17-positive gastric cancer cells in zebrafish embryos and rapidly visualize the tumor mass in mice within 3 h when conjugated with imaging dyes. E8 nanobody fused with toxin PE38 showed excellent anti-tumor effect and remarkably improved the mice survival in cell-derived (CDX) and patient-derived xenograft (PDX) models. The immunotoxin also enhanced the anti-tumor effect of clinical drug 5-Fluorouracil. Conclusions: The study presents a novel imaging and drug delivery strategy by targeting CDH17. CDH17 nanobodybased immunotoxin is potentially a promising therapeutic modality for clinical translation against gastric cancer.

Two-Dimensional Unilamellar Cation-Deficient Metal Oxide Nanosheet Superlattices for High-Rate Sodium Ion Energy Storage

Xiong, Pan,Zhang, Xiuyun,Zhang, Fan,Yi, Ding,Zhang, Jinqiang,Sun, Bing,Tian, Huajun,Shanmukaraj, Devaraj,Rojo, Teofilo,Armand, Michel,Ma, Renzhi,Sasaki, Takayoshi,Wang, Guoxiu American Chemical Society 2018 ACS NANO Vol.12 No.12

<P>Cation-deficient two-dimensional (2D) materials, especially atomically thin nanosheets, are highly promising electrode materials for electrochemical energy storage that undergo metal ion insertion reactions, yet they have rarely been achieved thus far. Here, we report a Ti-deficient 2D unilamellar lepidocrocite-type titanium oxide (Ti<SUB>0.87</SUB>O<SUB>2</SUB>) nanosheet superlattice for sodium storage. The superlattice composed of alternately restacked defective Ti<SUB>0.87</SUB>O<SUB>2</SUB> and nitrogen-doped graphene monolayers exhibits an outstanding capacity of ∼490 mA h g<SUP>-1</SUP> at 0.1 A g<SUP>-1</SUP>, an ultralong cycle life of more than 10000 cycles with ∼0.00058% capacity decay per cycle, and especially superior low-temperature performance (100 mA h g<SUP>-1</SUP> at 12.8 A g<SUP>-1</SUP> and −5 °C), presenting the best reported performance to date. A reversible Na<SUP>+</SUP> ion intercalation mechanism without phase and structural change is verified by first-principles calculations and kinetics analysis. These results herald a promising strategy to utilize defective 2D materials for advanced energy storage applications.</P> [FIG OMISSION]</BR>

Preparation and Sintering of Nano-sized W-Ni -Fe Powder by Sol-Spray-Drying Process

Fan Jinglian,Liu Tao,Ma Yunzhu,Cheng Huichao 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1

Transcriptome Network Analysis Reveals Potential Candidate Genes for Esophageal Squamous Cell Carcinoma

Ma, Zheng,Guo, Wei,Niu, Hui-Jun,Yang, Fan,Wang, Ru-Wen,Jiang, Yao-Guang,Zhao, Yun-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

The esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with a poor prognosis. Understanding molecular changes in ESCC should improve identification of risk factors with different molecular subtypes and provide potential targets for early detection and therapy. Our study aimed to obtain a molecular signature of ESCC through the regulation network based on differentially expressed genes (DEGs). We used the GSE23400 series to identify potential genes related to ESCC. Based on bioinformatics we constructed a regulation network. From the results, we could establish that many transcription factors and pathways closely related with ESCC were linked by our method. STAT1 also arose as a hub node in our transcriptome network, along with some transcription factors like CCNB1, TAP1, RARG and IFITM1 proven to be related with ESCC by previous studies. In conclusion, our regulation network provided information on important genes which might be useful in investigating the complex interacting mechanisms underlying the disease.

Research on the Accessibility of Urban Green Space Based on Road Network- A Case Study of the Park Green Space in City Proper of Nanjing

Fan, Yong,Zhao, Ming-yuan,Ma, Lin,Zhao, Lan-yong Institute of Forest Science 2016 Journal of Forest Science Vol.32 No.1

Accessibility of urban green space, as an important index of evaluating the service level of urban green space, not only shows the resident's access to green space, but also reflects the environment quality of urban living. Since the quantity, area and space distribution of the patches in urban green space directly affect the function of urban green space and the quality of urban environment, the research on the accessibility of urban green space holds great significance to improve the service of urban green space and the living environment quality. Based on GIS software, this research uses the road network and the population distribution data of Nanjing's city proper to conduct quantitative analysis of the accessibility of park green space and the convenience for residents to travel under different forms of transportation. After the case analysis, the author tests the application of road network in studying the accessibility of urban park green space and proposes a GIS-based method to study the accessibility and the rational layout of urban green space.

A Case Study on Change Detection from Thermatic Mapper(TM) data for Monitoring Land Resource in Mountainous Region

Ma, Jia,Fan, Hai Sheng,Chen, Xiu Wan 대한원격탐사학회 2000 International Symposium on Remote Sensing Vol.16 No.1

With background of application of sustainable development strategy and protection of earth's resource, land use and land cover change has gained more focus because of its role in regional social and economic development and global environment change. In this study, a new method has been proposed for change detection from remote sensing data such as Thermatic Mapper data. With thoughts derived from theory of Remote Sensing Information Model (RSIM), this article has tried to explore core characteristics of RSIM on LUCC, of which one is typical of the model, i.e., there exists disturbed information and pseudo-information among remote sensing data being processed. These kinds of information had been analyzed, and relevant methods proposed to remove them in order to obtain proper changed information LUCC. GIS becomes the basic environment to process and integrate different kinds of data, such GPS data and land use survey data and DEM. How to carry out terrain correction in case of mountainous area will be a care problem, in the next stage of study.