Dermatologic Aspects of Hyperlipoproteinemia

Braun-Falco, O. Yonsei University, College of Medicine 1978 Yonsei medical journal Vol.19 No.2

The discovery of placenta growth factor and its biological activity

De Falco, Sandro Korean Society for Biochemistry and Molecular Bion 2012 Experimental and molecular medicine Vol.44 No.1

Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and ovary during the different phases of the menstrual cycle and to the heart and skeletal muscles after prolonged and sustained physical exercise. Conversly, angiogenesis is one of the major pathological changes associated with several complex diseases like cancer, atherosclerosis, arthritis, diabetic retinopathy and age-related macular degeneration. Among the several molecular players involved in angiogenesis, some members of VEGF family, VEGF-A, VEGF-B and placenta growth factor (PlGF), and the related receptors VEGF receptor 1 (VEGFR-1, also known as Flt-1) and VEGF receptor 2 (VEGFR-2, also known as Flk-1 in mice and KDR in human) have a decisive role. In this review, we describe the discovery and molecular characteristics of PlGF, and discuss the biological role of this growth factor in physiological and pathological conditions.

REVIEW : Antiangiogenesis therapy: an update after the first decade

( Sandro De Falco ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.1

Angiogenesis is a complex biological phenomenon that forms new blood vessels from the pre-existing vasculature. Aberrant angiogenesis has been implicated in a variety of diseases such as cancer, atherosclerosis, arthritis, obesity, pulmonary hypertension, diabetic retinopathy, and age-related macular degeneration. These conditions collectively affect nearly 10% of the global population. Much effort has focused on identifying new therapeutic agents that inhibit pathological angio-genesis since 1971, when Judah Folkman published the hypothesis that tumor growth is angiogenesis-dependent and that its inhibition may be therapeutic. In 2004, the U.S. Food and Drug Administration approved the first antiangiogenic drug for the treatment of metastatic colon cancer, bevacizumab (Avastin, Genen-tech). This drug is a humanized monoclonal antibody that neutralizes the vascu-lar endothelial growth factor. It is used in combination with chemotherapy, and its use began the era of antiangiogenesis therapy. Several new therapeu-tic agents have been added to the list of approved drugs, and clinical trials of new therapeutic options and antiangiogenic agents are ongoing. This review describes the progress made in the first decade of antiangiogenesis therapy, and addresses both validated and possible targets for future drug development.

태반 성장인자의 발견과 생물학적 활성

( Sandro De Falco ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 생화학분자생물학회 소식 Vol.32 No.1

The discovery of placenta growth factor and its biological activity

Sandro De Falco 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.1

Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and ovary during the different phases of the menstrual cycle and to the heart and skeletal muscles after prolonged and sustained physical exercise. Conversly, angiogenesis is one of the major pathological changes associated with several complex diseases like cancer, atherosclerosis, arthritis,diabetic retinopathy and age-related macular degeneration. Among the several molecular players involved in angiogenesis, some members of VEGF family,VEGF-A, VEGF-B and placenta growth factor (PlGF), and the related receptors VEGF receptor 1(VEGFR-1, also known as Flt-1) and VEGF receptor 2(VEGFR-2, also known as Flk-1 in mice and KDR in human)have a decisive role. In this review, we describe the discovery and molecular characteristics of PlGF,and discuss the biological role of this growth factor in physiological and pathological conditions.

Dermatologic Aspects of Hyperlipoproteinemias

Otto Braun - Falco 대한피부과학회 1978 大韓皮膚科學會誌 Vol.16 No.5

Colloid Milium is a degenerative disease in the dermal connective tissue characterized by the development of yellowish translucent papules or plaques on sun exposed skin. Clinically, there are two types of colloid milium namely, a juvenile type which starts before puberty and an adult type which involves sun exposed areas of adults. In both types the lesion is limited to the skin. Histologically colloid milium, like amyloid, shows homogenous, fissured aggregates, staining faintly eosinophilic, and occupying most or all of the involved. dermal papillae. A case of colloid. milium in 46 year old female is reported. About 4 years ago numerous yellowis4 translucent papules, 0. 1~0. 2cm in diameter developei on nose and lateral aspects of both eyes, which were gradually increasing in its size. Diagnosed confirmed by clinical features and histopathologic finding. Literature were reviewed.

Theories and Research for the Study of Phenomena in the Client Domain of Nursing : Recent Advances in Nursing: Major concepts in the development of nursing theory

( S. M. Falco ) 서울대학교 간호과학연구소 1999 서울대학교 간호과학연구소 학술대회 자료집 Vol.1999 No.2

Stochastic identification of masonry parameters in 2D finite elements continuum models

Giada Bartolini,Anna De Falco,Filippo Landi Techno-Press 2023 Coupled systems mechanics Vol.12 No.5

The comprehension and structural modeling of masonry constructions is fundamental to safeguard the integrity of built cultural assets and intervene through adequate actions, especially in earthquake-prone regions. Despite the availability of several modeling strategies and modern computing power, modeling masonry remains a great challenge because of still demanding computational efforts, constraints in performing destructive or semi-destructive in-situ tests, and material uncertainties. This paper investigates the shear behavior of masonry walls by applying a plane-stress FE continuum model with the Modified Masonry-like Material (MMLM). Epistemic uncertainty affecting input parameters of the MMLM is considered in a probabilistic framework. After appointing a suitable probability density function to input quantities according to prior engineering knowledge, uncertainties are propagated to outputs relying on gPCE-based surrogate models to considerably speed up the forward problem-solving. The sensitivity of the response to input parameters is evaluated through the computation of Sobol' indices pointing out the parameters more worthy to be further investigated, when dealing with the seismic assessment of masonry buildings. Finally, masonry mechanical properties are calibrated in a probabilistic setting with the Bayesian approach to the inverse problem based on the available measurements obtained from the experimental load-displacement curves provided by shear compression in-situ tests.

Iron supplement tablet embedded in the oral cavity mimicking neoplasm: a case report

Fabrizio Corlianò,Paola Falco,Jacopo Cambi,Leopoldo Brindisi 대한구강악안면외과학회 2016 대한구강악안면외과학회지 Vol.42 No.2

The detection of foreign bodies in the upper-aerodigestive tract is a fairly frequent event and can occur in various areas and for various reasons. In rare cases, foreign bodies can simulate a neoplasia. We evaluated similar cases during emergency regimen with an oral cavity mucosal lesion, causing lockjaw, sore throat, dysphagia, and swelling of the submandibular and laterocervical region. Physical examination revealed an extensive mucosal ulceration in the floor of the mouth and the lateral surface of the tongue, comparable to oral cancer. During a second, more accurate assessment, a partially deteriorated iron supplement tablet was found embedded in a mucosal pocket. After removing the tablet, gradual normalization of the tissue was ob- served without any sequelae. This is one of the many reasons why it is advisable and useful in cases of oral lesions to collect a detailed medical history and to perform an accurate clinical evaluation, including inspection and palpation of the lesion, before proceeding to further diagnostic assessments, especially in elderly patients taking many medications. However unlikely, it is possible that difficulty in swallowing pills or tablets could generate tumorlike lesions.

Identification of novel mutations in L1CAM gene by a DHPLC-based assay

Mirella Vinci,Michele Falco,Lucia Castiglia,Lucia Grillo,Angela Spalletta,Maurizio Sturnio,Ornella Galesi,Michele Salemi,Angelo Gloria,Silvestra Amata,Maria Piccione,Vincenzo Antona,Girolamo Aurelio V 한국유전학회 2016 Genes & Genomics Vol.38 No.12

X-linked hydrocephalus, MASA syndrome, X-linked complicated Spastic Paraplegia Type I, and X-linked partial agenesis of the corpus callosum are rare diseases mainly affecting male population and broadly referred as L1 syndrome, caused by mutations in the L1CAM gene. In the present study 36 boys and a male fetus whose clinical features were consistent with L1 syndrome were analyzed by dHPLC assay and direct sequencing of L1CAM gene. Sequence analysis of the 14 different aberrant dHPLC elution profiles demonstrated that six of them were associated with already reported polymorphisms, four with previously described causative variants while the remaining four represented novel L1CAM mutations. The dHPLC method proposed identified eight (21 %) causative L1CAM mutations in our patients while direct sequencing failed to detect any variation in patients negative to dHPLC analysis. We conclude that the dHPLC assay represents a fast and efficient method for the screening of L1CAM mutations and that L1 syndrome should be considered in the differential diagnosis of intellectual disability in children, especially when other signs such as hydrocephalus or adducted thumbs are present.