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A Case Report on the Effect of Sham Acupuncture
Vera Lucia Rasera Zotelli,Cássia Maria Grillo,Maria da Luz Rosário de Sousa 사단법인약침학회 2016 Journal of Acupuncture & Meridian Studies Vol.9 No.5
When nausea, an extremely unpleasant symptom, is experienced during dental treatment, it generates disorders and obstacles for both the patient and the professional, compromising the good quality of dental care. Clinical studies have confirmed the antiemetic action of acupuncture and shown its use for the treatment of nausea and vomiting. In the scientific literature there are several recent studies that address the placebo effect of acupuncture. The aim of this manuscript is to present a case report of a 46-year-old Caucasian male patient, who had severe symptoms of nausea while undergoing dental care. Treatment with sham acupuncture (acupuncture simulation) obtained a positive result of nausea prevention. We will discuss three possible hypotheses concerning this result: (1) there was action of Deqi; (2) high expectations of the patient; and (3) association with specific learned response. The patient in this case report received nonpenetrating sham acupuncture at acupoint Neiguan (PC6), which resulted in the complete remission of nausea during an intra-oral impression-taking procedure, but it is unclear whether the placebo effect was triggered by the action of Deqi, the high expectations of the patient, an association with a learned response, or by the interaction of all these factors.
Vera Lucia Rasera Zotelli,Ca´ssia Maria Grillo,Maria da Luz Rosa´rio de Sousa 사단법인약침학회 2014 Journal of Acupuncture & Meridian Studies Vol.7 No.6
The objective of this study was to evaluate the effectiveness of acupuncture point PC6 (Neiguan) in controlling nausea during intraoral impression taking. This study was con- ducted in Piracicaba, Sa ˜o Paulo, Brazil. The sample consisted of 33 adult volunteers with nausea, who were randomly divided into control and study groups, and treated with non- penetrating sham acupuncture and real acupuncture, respectively, at acupoint PC6. The two groups had two maxillary impressions taken, one prior to acupuncture and the other after acupuncture. The nausea assessment was made using the visual analog scale, Gagging Severity Index (GSI), and Gagging Prevention Index. Volunteers’ expectation that nausea would be reduced through acupuncture was also assessed. For statistical analysis, we used the t test and the Spearman correlation (p < 0.05). When assessed by Gagging Severity Index/Gagging Prevention Index, nausea was reduced in the real acupuncture group (p < 0.01). In the visual analog scale assessment, similar reductions of nausea were noted in both groups (p > 0.05). No correlation existed between the expected and the actual reductions in nausea. Our results indicate that acupoint PC6 was effective for con- trolling nausea during the maxillary impression-taking procedure. Patients’ expectation did not influence the results.
Identification of novel mutations in L1CAM gene by a DHPLC-based assay
Mirella Vinci,Michele Falco,Lucia Castiglia,Lucia Grillo,Angela Spalletta,Maurizio Sturnio,Ornella Galesi,Michele Salemi,Angelo Gloria,Silvestra Amata,Maria Piccione,Vincenzo Antona,Girolamo Aurelio V 한국유전학회 2016 Genes & Genomics Vol.38 No.12
X-linked hydrocephalus, MASA syndrome, X-linked complicated Spastic Paraplegia Type I, and X-linked partial agenesis of the corpus callosum are rare diseases mainly affecting male population and broadly referred as L1 syndrome, caused by mutations in the L1CAM gene. In the present study 36 boys and a male fetus whose clinical features were consistent with L1 syndrome were analyzed by dHPLC assay and direct sequencing of L1CAM gene. Sequence analysis of the 14 different aberrant dHPLC elution profiles demonstrated that six of them were associated with already reported polymorphisms, four with previously described causative variants while the remaining four represented novel L1CAM mutations. The dHPLC method proposed identified eight (21 %) causative L1CAM mutations in our patients while direct sequencing failed to detect any variation in patients negative to dHPLC analysis. We conclude that the dHPLC assay represents a fast and efficient method for the screening of L1CAM mutations and that L1 syndrome should be considered in the differential diagnosis of intellectual disability in children, especially when other signs such as hydrocephalus or adducted thumbs are present.
Would a Placebo Acupuncture Needle be Able to Induce Deqi?
Ca´ssia Maria Grillo,Vera Lucia Rasera Zotelli,Maria Lu´cia Bressiani Gil,Maria da Luz Rosa´rio de Sousa 사단법인약침학회 2018 Journal of Acupuncture & Meridian Studies Vol.11 No.5
The aim of this study was to evaluate Deqi in patients under treatment with acupunctureand sham acupuncture. Forty (40) volunteers of all genders with temporomandibulardysfunction (TMD) were randomized into two study groups: Acupuncture and ShamAcupuncture (non-penetrating device). The patients answered the Southampton NeedleSensation Questionnaire (SNSQ) at the initial and final sessions of acupuncture treatment. The questionnaire was composed of two parts: the first one, consisting of 17 Deqi descriptorsand a Likert scale in order to evaluate the intensity of each sensation; and the secondone, consisting of a visual analog scale (VAS) to evaluate how painful the acupuncturetreatment was. At the initial session, LI4 was the most cited acupuncture point in bothgroups, being responsible for a ‘Slight Intensity’ needling sensation of electric shock inthe acupuncture group at initial (10%) and final (15%) sessions. The most common relatedneedling sensations at different acupuncture points was “Pricking” and “Sharp” in bothgroups. The acupuncture group showed higher VAS than the Sham Acupuncture eitherin the initial (3.87 2.43) and final (2.04 2.14) sessions. Deqi response to acupuncturestimulation was verified either in the both groups.
CLASH-VLT: Environment-driven evolution of galaxies in the<i>z</i>= 0.209 cluster Abell 209
Annunziatella, M.,Mercurio, A.,Biviano, A.,Girardi, M.,Nonino, M.,Balestra, I.,Rosati, P.,Bartosch Caminha, G.,Brescia, M.,Gobat, R.,Grillo, C.,Lombardi, M.,Sartoris, B.,De Lucia, G.,Demarco, R.,Frye, EDP Sciences 2016 Astronomy and astrophysics Vol.585 No.-