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Walclecio de Moraes Lira,Fabio Vieira dos Santos,Miriam Sannomiya,Clenilson Martins Rodrigues,Wagner Vilegas,Eliana Aparecida Varanda 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
Byrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian “cerrado” (tropical Americansavanna), and the local population uses it to treat diseases, such as diarrhea and gastric ulcer. It belongs to the Malpighiaceaefamily, and it is commonly known as “murici.” Considering the popular use of B. basilobaderivatives and the lack of phar-macological potential studies regarding this vegetal species, the mutagenic and antimutagenic effect of methanol (MeOH) andchloroform extracts were evaluated by the Ames test, using strains TA97a, TA98, TA100, and TA102 of Salmonella ty-phimurium. No mutagenic activity was observed in any of the extracts. To evaluate the antimutagenic potential, direct and in-direct mutagenic agents were used: 4 nitro-o-phenylenediamine, sodium azide, mitomycin C, aflatoxin B1, benzo[a]pyrene,and hydrogen peroxide. Both the extracts evaluated showed antimutagenic activity, but the highest value of inhibition level(89%) was obtained with the MeOH extract and strain TA100 in the presence of aflatoxin B1. Phytochemical analysis of theextracts revealed the presence of n-alkanes, lupeol, ursolic and oleanolic acid, (. )-catechin, quercetin-3-O-.-L-arabinopyra-noside, gallic acid, methyl gallate, amentoflavone, quercetin, quercetin-3-O-(2.-O-galloyl)-.-D-galactopyranoside, andquercetin-3-O-(2.-O-galloyl)-.-L-arabinopyranoside.