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RISS 인기검색어
- 검색키워드
- 저자 : F. J. Salvador (검색결과 5 건)
- 무료
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Salvador Amadeo F.,Shyu Chi-Ren,Parks Elizabeth J. 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Over the past 70 years, the study of lipid metabolism has led to important discoveries in identifying the underlying mechanisms of chronic diseases. Advances in the use of stable isotopes and mass spectrometry in humans have expanded our knowledge of target molecules that contribute to pathologies and lipid metabolic pathways. These advances have been leveraged within two research paths, leading to the ability (1) to quantitate lipid flux to understand the fundamentals of human physiology and pathology and (2) to perform untargeted analyses of human blood and tissues derived from a single timepoint to identify lipidomic patterns that predict disease. This review describes the physiological and analytical parameters that influence these measurements and how these issues will propel the coming together of the two fields of metabolic tracing and lipidomics. The potential of data science to advance these fields is also discussed. Future developments are needed to increase the precision of lipid measurements in human samples, leading to discoveries in how individuals vary in their production, storage, and use of lipids. New techniques are critical to support clinical strategies to prevent disease and to identify mechanisms by which treatments confer health benefits with the overall goal of reducing the burden of human disease.
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Raul Payri,F. J. Salvador,J. Gimeno,V. Soare 대한기계학회 2005 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.19 No.11
The present paper centers on the establishment of a quantified relationship between the macroscopic visual parameters of a Diesel spray and its most influential factors. The factors considered are the ambient gas density, as an external condition relative to the injection system, and nozzle hole diameter and injection pressure as internal ones. The main purpose of this work is to validate and extend the different correlations available in the literature to the present state of the Diesel engine, i.e. high injection pressure, small nozzle holes, severe cavitating conditions, etc. Five mono-orifice, axi-symmetrical nozzles with different diameters have been studied in two different test rigs from which one can reproduce solely the real engine in-cylinder air density, and the other, both the density and the pressure. A parametric study was carried out and it enabled the spray tip penetration to be expressed as a function of nozzle hole diameter, injection pressure and environment gas density. The temporal synchronization of the penetration and injection rate data revealed a possible explanation for the discontinuity observed as well by other authors in the spray’s penetration law. The experimental results obtained from both test rigs have shown good agreement with the theoretical analysis. There have been observed small but consistent differences between the two test rigs regarding the spray penetration and cone angle, and thus an analysis of the possible causes for these differences has also been included.
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Payri, Raul,Molina, S.,Salvador, F.J.,Gimeno, J. The Korean Society of Mechanical Engineers 2004 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.18 No.7
This study examines the influence of geometry on the internal flow and macroscopic behavior of the spray in Diesel nozzles. For this investigation, two bi-orifice nozzles were employed: one cylindrical and one conical. The first step is to use a non-destructive characterization method which is based on the production of silicone moulds so that the precise internal geometry of the two nozzles can be measured. At this stage the nozzles have been characterized dimensionally and therefore the internal flow can be studied using CFD calculations. The results gained from this experiment make it possible also to ascertain the critical cavitation conditions. Once the critical cavitation conditions have been identified, the macroscopic parameters of the spray can be studied in both cavitating and non-cavitating conditions using a test rig pressurized with nitrogen and with the help of a image acquisition system and image processing software. Consequently, research can be carried out to determine the influence that cavitation has on macroscopic spray behavior. From the point of view of the spray macroscopic behavior, the main conclusion of the paper is that cavitation leads to an increment of the spray cone angle. On the other hand, from the point of view of the internal flow, the hole outlet velocity increases when cavitation appears. This phenomenon can be explained by the reduction in the cross section of the liquid phase in the outlet section of the hole.
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Raul Payri,S. Molina,F. J. Salvador,J. Gimeno 대한기계학회 2004 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.18 No.7
This study examines the influence of geometry on the internal flow and macroscopic behavior of the spray in Diesel nozzles. For this investigation, two bi-orifice nozzles were employed: one cylindrical and one conical. The first step is to use a non-destructive characterization method which is based on the production of silicone moulds so that the precise internal geometry of the two nozzles can be measured. At this stage the nozzles have been characterized dimensionally and therefore the internal flow can be studied using CFD calculations. The results gained from this experiment make it possible also to ascertain the critical cavitation conditions. Once the critical cavitation conditions have been identified, the macroscopic parameters of the spray can be studied in both cavitating and non-cavitating conditions using a test rig pressurized with nitrogen and with the help of a image acquisition system and image processing software. Consequently, research can be carried out to determine the influence that cavitation has on macroscopic spray behavior. From the point of view of the spray macroscopic behavior, the main conclusion of the paper is that cavitation leads to an increment of the 'spray cone angle. On the other hand, from the point of view of the internal flow, the hole outlet velocity increases when cavitation appears. This phenomenon can be explained by the reduction in the cross section of the liquid phase in the outlet section of the hole.
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