Coordinating strategic outsourcing decisions for semiconductor assembly using a bi-objective genetic algorithm

Wu, J. Z.,Chien, C. F.,Gen, M. Taylor Francis 2012 INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH - Vol.50 No.1

Effects of calcium silicate cements on neuronal conductivity

Deniz-Sungur Derya,Onur Mehmet Ali,Akbay Esin,Tan Gamze,Daglı-Comert Fügen,Sayın Taner Cem 대한치과보존학회 2022 Restorative Dentistry & Endodontics Vol.47 No.2

Objectives This study evaluated alterations in neuronal conductivity related to calcium silicate cements (CSCs) by investigating compound action potentials (cAPs) in rat sciatic nerves. Materials and Methods Sciatic nerves were placed in a Tyrode bath and cAPs were recorded before, during, and after the application of test materials for 60-minute control, application, and recovery measurements, respectively. Freshly prepared ProRoot MTA, MTA Angelus, Biodentine, Endosequence RRM-Putty, BioAggregate, and RetroMTA were directly applied onto the nerves. Biopac LabPro version 3.7 was used to record and analyze cAPs. The data were statistically analyzed. Results None of the CSCs totally blocked cAPs. RetroMTA, Biodentine, and MTA Angelus caused no significant alteration in cAPs (p > 0.05). Significantly lower cAPs were observed in recovery measurements for BioAggregate than in the control condition (p < 0.05). ProRoot MTA significantly but transiently reduced cAPs in the application period compared to the control period (p < 0.05). Endosequence RRM-Putty significantly reduced cAPs. Conclusions Various CSCs may alter cAPs to some extent, but none of the CSCs irreversibly blocked them. The usage of fast-setting CSCs during apexification or regeneration of immature teeth seems safer than slow-setting CSCs due to their more favorable neuronal effects.

Targeted axillary biopsy and sentinel lymph node biopsy for axillary restaging after neoadjuvant chemotherapy

Gunay Gurleyik,Sibel Aydin Aksu,Fügen Aker,Kubra Kaytaz Tekyol,Eda Tanrikulu,Emin Gurleyik 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.6

Purpose: Accurate restaging of the axilla after neoadjuvant chemotherapy (NAC) is an important issue to ensure deescalating axillary surgery in patients with initial metastatic nodes. We aimed to present our results of targeted axillary biopsy (TAB) combined with sentinel lymph node biopsy (SLNB) for axillary restaging after NAC. Methods: In 64 breast cancer patients who underwent NAC, biopsy-proven positive nodes were marked with clips before NAC, and ultrasound-guided wire localization of clip-marked nodes was performed after NAC. Patients underwent TAB and SLNB for post-NAC axilla restaging. Results: Identification rates of post-NAC TAB and SLNB were 98.4% and 87.5%, respectively (P = 0.033). Histopathology revealed a nodal pathologic complete response (pCR) rate of 47% in which axillary lymph node dissection (ALND) was avoided. TAB alone and SLNB alone detected residual disease in 29 (85.3%) and 20 (58.8%) patients (P = 0.029), respectively. Whereas rates of up to 97% had been achieved with a combination of TAB and SLNB. The pCR rates after NAC were 64.3% for human epidermal growth factor receptor 2 positive and triple-negative tumors and 13.6% in luminal tumors (P = 0.0002). Conclusion: Pathologic analysis following TAB combined with SLNB revealed the pCR rates to NAC in a considerable number of patients that provided de-escalation of axillary surgery. A combination of SLNB and TAB was found to be an accurate procedure in establishing residual nodal disease. This combined procedure in patients with initially positive nodes was a reliable method for post-NAC axillary restaging.

Can Fecal Calprotectin Level Be Used as a Markers of Inflammation in the Diagnosis and Follow-Up of Cow's Milk Protein Allergy?

Ömer Faruk Beşer,,Selim Sancak,Tülay Erkan,Tufan Kutlu,Haluk Çokuğraş,Fügen Ç. Çokuğraş 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.1

Purpose: Calprotectin is a cytosolic protein with immunomodulatory, antimicrobial, and antiproliferative actions. The concentration of calprotectin increases in infection, inflammation, and malignancy. We determined if calprotectin can be used as a marker for the diagnosis and follow-up of bowel inflammation in cow’s milk protein allergy (CMPA). Methods: In total, 32 patients newly diagnosed with CMPA were included (24 IgE-mediated, 8 non-IgE-mediated). In all subjects, a complete blood count, total IgE, cow’s milk-specific IgE, and fecal calprotectin (FC) were assessed before and after a cow’s milk protein (CMP) elimination diet was started. The results were compared with those of 39 healthy children. Results: The mean FC value before the CMP elimination diet was 516±311 μg/g in the 32 patients with CMPA and 296±94 μg/g in the control group (P=0.011). The mean FC value after the diet in these patients was 254±169 μg/g, which was significantly different from the mean value before the CMP elimination diet (P<0.001). When we compared FC levels before the CMP elimination diet in the IgE-mediated group with the control group, we found no significant statistical difference (P=0.142). The mean FC value before the CMP elimination diet was 886±278 μg/g in the non-IgE-mediated group and 296±94 μg/g in the control group; this difference was statistically significant (P<0.001). In the IgE-mediated and non-IgE-mediated groups, FC values after CMP elimination diet were 218±90 μg/g and 359±288 μg/g, respectively, and FC values before CMP elimination diet were 392±209 μg/g and 886±278 μg/g, respectively; these differences were statistically significant (P=0.001 and P=0.025, respectively). Conclusions: FC levels may be a useful marker for follow-up treatment and recurrence determination in CMPA.

Collapse of steel cantilever roof of tribune induced by snow loads

Ahmet C. Altunışık,Şevket Ateş,Metin Hüsem,Ali F. Genç 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.23 No.3

In this paper, it is aimed to present a detail investigation related to structural behavior of laterally unrestrained steel cantilever roof of tribune with slender cross section. The structure is located in Tutak town in A&$287;rı and collapsed on October 25, 2015 at eastern part of Turkey is considered as a case study. This mild sloped roof structure was built from a variable I beam, and supported on steel columns of 5.5 m height covering totally 240 m² closed area in plan. The roof of tribune collapsed completely without any indication during first snowfall after construction at midnight a winter day, fortunately before the opening hours. The meteorological records and observations of local persons are combined together to estimate the intensity of snow load in the region and it is compared with the code specified values. Also, the wide/thickness and height/thickness ratios for flange and web are evaluated according to the design codes. Three dimensional finite element model of the existing steel tribune roof is generated considering project drawings and site investigations using commercially available software ANSYS. The displacements, principal stresses and strains along to the cantilever length and column height are given as contour diagrams and graph format. In addition to site investigation, the numerical and analytical works conducted in this study indicate that the unequivocal reasons of the collapse are overloading action of snow load intensity, some mistakes made in the design of steel cantilever beams, insufficient strength and rigidity of the main structural elements, and construction workmanship errors.

Analysis of stress distribution in anchorage zones of pretensioned beams

F. Gens,J-C. Dotreppe 한국계산역학회 2004 Computers and Concrete, An International Journal Vol.1 No.3

The stress transmission mechanism in pretensioned concrete beams, though very interesting from an economical point of view, is very complex, integrating various phenomenons such as sliding, bond, bursting. For long the complexity of this mechanism has led engineers to provide a massive rectangular anchorage zone at each end of the beam. The necessity of using such a concrete reinforcementis certainly unquestionable in post-tensioned beams. However in pretensioned elements the stresses induced in concrete in the anchorage zone are smaller than in post-tensioned elements. In this article the stress field in the end zone is calculated numerically and from this analysis the possible reduction of the cross-section of the anchorage block is examined.

Configuration Dependence of Toroidal Current in Heliotron J

gen Motojima,F. Sano,H. Yabutani,H. Okada,H. Nakamura,H. Arimoto,H. Kitagawa,H. Yamazaki,K. Kondo,K. Nagasaki,K. Hanatani,K.Y. Watanabe,M. Kaneko,M. Uno,S. Fujikawa,S. Watanabe,S. Yamamoto,S. Kobayash 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III

A change of toroidal current by controlling the magnetic configuration has been observed in Heliotron J. The effect of the magnetic configuration on the neoclassical bootstrap current has been theoretically investigated for Heliotron J. It is found that the bumpy field component (B04) plays an important role in changing both the value and the direction of the bootstrap current in Heliotron J. The bootstrap current density is reversed at the small minor radius first, and then the net bootstrap current changes its direction from a positive value to a negative value as B04 decreases.