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Lee, Jaesung,Park, Jonghan,Park, Jangmi,Lee, Chamkyul,Jeong, Suhyeon,Kong, Kyunghwan,Lee, Eunyong The Society of Korean Medicine 2019 대한한의학회지 Vol.40 No.4
Objectives: The objective of this study was to report the general characteristics, satisfaction, and changes before and after treatment to foreign athletes and officials who were received Korean Medicine at the 2019 Chungju World Martial Arts Masterships Korean Medical Clinic. Methods: We investigated age, gender, nationality, type of sports, and, onset through medical records. Besides, we developed the patient satisfaction survey to determine how satisfied the patients were with the treatment they received. The survey included type of injury, location of the injury, cause of injury, Numeric Rating Scale (NRS) before and after treatment, and treatment satisfaction. Result: This study showed that knee and lower leg injuries (S80-S89) were the most frequent injuries in the Korean Medicine(KM) clinic of the 2019 Chungju World Martial Arts Masterships. We provided KM treatments including acupuncture, cupping therapy, Chuna manual therapy, herbal medicine, dressing, and taping. Acupuncture was the most frequently performed and the most satisfactory treatment. The average NRS after treatment significantly decreased, suggesting that KM is effective in controlling pain in sports injuries. The overall satisfaction was also high with KM treatments.
Soluble ACE2 and TMPRSS2 Levels in the Serum of Asthmatic Patients
Lee Ji-Hyang,Lee Chae Eun,Yoo Youngsang,Shin Eunyong,An Jin,Park Seo Young,Song Woo-Jung,Kwon Hyouk-Soo,Cho You Sook,Moon Hee-Bom,Kim Tae-Bum 대한의학회 2022 Journal of Korean medical science Vol.37 No.8
Background: Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) are key proteins mediating viral entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although gene expressions of ACE2 and TMPRSS2 have been analyzed in various organs and diseases, their soluble forms have been less studied, particularly in asthma. Therefore, we aimed to measure circulating ACE2 and TMPRSS2 in the serum of asthmatics and examine their relationship with clinical characteristics. Methods: Clinical data and serum samples of 400 participants were obtained from an asthma cohort. The soluble ACE2 (sACE2) and soluble TMPRSS2 (sTMPRSS2) level was measured by enzyme-linked immunosorbent assay, and the values underwent a natural log transformation. Associations between sACE2 and TMPRSS2 levels and various clinical variables were analyzed. Results: The patients younger than 70 years old, those with eosinophilic asthma (eosinophils ≥ 200 cells/µL), and inhaled corticosteroids (ICS) non-users were associated with higher levels of sACE2. Blood eosinophils and fractionated exhaled nitric oxide levels were positively correlated with serum ACE2. In contrast, lower levels of sTMPRSS2 were noted in patients below 70 years and those with eosinophilic asthma, while no association was noted between ICS use and sTMPRSS2. The level of sTMPRSS2 also differed according to sex, smoking history, coexisting hypertension, and forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio. The proportion of sputum neutrophils was positively correlated with sTMPRSS2, while the FEV1/FVC ratio reported a negative correlation with sTMPRSS2. Conclusion: The levels of ACE2 and TMPRSS2 were differently expressed according to age, ICS use, and several inflammatory markers. These findings suggest variable susceptibility and prognosis of SARS-CoV-2 infection among asthmatic patients.
Seo, Eunyong,Lee, Taemin,Lee, Kyu Tae,Song, Hyun-Kon,Kim, Byeong-Su The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.23
<P>The facile synthetic approach to ruthenium oxide nanoparticles using double hydrophilic block copolymers (DHBCs) and their application toward the supercapacitor are presented. Nanostructured hydrous ruthenium oxide (RuO<SUB>2</SUB>) nanoparticles are synthesized using a double hydrophilic block copolymer of poly(ethylene oxide)-<I>block</I>-poly(acrylic acid) (PEO-<I>b</I>-PAA) as a template, forming a micelle upon addition of the ruthenium precursor, which then transformed into RuO<SUB>2</SUB> nanoparticles of controlled dimension with reducing agents. The synthesized hydrous RuO<SUB>2</SUB>·<I>x</I>H<SUB>2</SUB>O nanoparticles are very stable for several months without any noticeable aggregates. Furthermore, we have demonstrated their utility in application as supercapacitors. Through annealing at 400 °C, we found that the crystallinity of RuO<SUB>2</SUB> nanoparticles increases considerably with a simultaneous transformation of the surrounding double hydrophilic block copolymer into ionic and electronic conducting buffer layers atop RuO<SUB>2</SUB> nanoparticles, which contribute to the significant enhancement of the overall specific capacitance from 106 to 962 F g<SUP>−1</SUP> at 10 mV s<SUP>−1</SUP>. The RuO<SUB>2</SUB> nanoparticles annealed at 400 °C also exhibit a superior retention of capacitance over 1000 cycles at very high charge–discharge rates at 20 A g<SUP>−1</SUP>. We envision that the double hydrophilic block copolymer will provide a facile and general tool in creating functional nanostructures with controlled dimensions that are useful for various applications.</P> <P>Graphic Abstract</P><P>The facile synthetic approach to ruthenium oxide nanoparticles using double hydrophilic block copolymers (DHBCs) and their application as supercapacitors are presented. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm30738c'> </P>