S_N1 치환 반응에 의한 N-불포화 알킬카르바졸 유도체의 합성에 관한 연구

정평진,조을훈 단국대학교 1998 論文集 Vol.32 No.-

N-unsaturated alkylcarbazole derivatives were synthesized by the unimolecular nucleophilic substitution(S_Nl) of a carbazole with an unsaturated alkyl chloride. The reaction between the carbazole and unsaturated alkyl chloride was conducted in dimethyl sulfoxide (DMSO) containing an alkali (NaOH or KOH) for 4hrs under nitrogen atmosphere at room temperature. At this time the mole ratios between the carbazole alkali and unsaturated alkyl chloride were found to be 1 : 6 : 1, 1 : 3 : 1 and 1 : 1 : 1, respectively. All the compounds including starting materials and reaction products were characterized by CHN analysis ^1H-NMR and FT - IR spectroscopy.

A case of trichilemmal cyst on the toe

( Cho Ah Lim ),( Myum Im ),( Young Lee ),( Young Joon Seo ),( Jeung Hoon Lee ),( Hae Eul Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Trichilemmal cysts are benign cutaneous tumors that originate from the outer root sheath of hair follicle and frequently affect middle-aged females. These are mostly found on the scalp and rarely involve the face, neck and trunk. A 30-year-old male visited our clinic for skin-colored, tender, subcutaneous nodule on the 5th toe of his right foot without any history of trauma. A complete excision of the tumor was performed. Histopathological examination revealed a trichilemmal cyst that is lined by a stratified squamous epithelium composed of swollen pale keratinocytes, without the formation of a granular layer. Only few cases have been reported to occur on locations with no hair follicles. This case describes a trichilemmal cyst on the toe, which is an unusual location for these tumors.

CFD 해석에 의한 도시의 풍환경 영향 평가 및 해석 방법에 관한 연구

조정훈(Cho, Jeong-Hoon),임사랑(Yim, Sa-Rang),이경수(Lee, Kyung-Su),한상을(Han, Sang-Eul) 대한건축학회 2012 大韓建築學會論文集 : 構造系 Vol.28 No.7

Recently, Artificial and irregular wind load is being occured because of the high-rise and high-density construction trends in the city. The wind environment problem of city is one of the heat island phenomenon causes. In the past, the city was focused on development of scale. But nowadays, in the environmental aspects of residents and pedestrians, the wind environmental awareness is growing. The three methods of wind environmental assessment are such as numerical methods, experimental methods and analytical methods. But, the numerical method by measure is nothing but impact assessment on the current state of the city can"t be a new alternative design assessment aspects of wind environmental improvement. So, the experimental method or the analytical method must be solve this problem. This paper show the reliability of CFD(computational fluid dynamics) analysis by comparing analytical result data with wind tunnel test result data based on the wind factor of measured data. Through this study, the applicability of CFD analysis that understand three-dimensional airflow characteristics demonstrated on environmental impact assessment is demonstrated. In this study, analytical results and wind tunnel results tend to match measured data results. as a result, We deem that the sufficient wind environmental assessment by CFD analysis is possible from the planning stage of large complex and high-rise buildings.

체중부하 수족부 전용 CT의 족부질환 진단의 유용성

이을규(Eul kyu Lee),조명훈(Myung hoon Cho),유태천(Tae chun Yu),이병상(Byung sang Lee),신원철(Weon Cheul Sin) 대한CT영상기술학회 2015 대한CT영상기술학회지 Vol.17 No.2

목적 : Weight bearing CT(이하 WBCT)의 족부질환 진단의 유용성과 WBCT 장비의 구조적, 기능적인 특성에 대해 알아보고자 한다. 대상 및 방법 : 본원 족부클리닉 내원 환자의 질환을 진단함에 있어 WBCT와 Non Weight bearing CT(이하 NWBCT)의 차이점을 조사하여 특정 질환의 진단적 가치를 평가하였다. 또한, WBCT 검사 시, 환자의 편의성, 피폭 감소에 대해서도 조사하였다. 결과 : NWBCT에 비해 WBCT는 환자의 체중 부하시의 상태를 그대로 영상화 할 수 있었다. 특히 OsteoArthrosis(OA), 평발(Flat foot) 및 외반증(valgus region) 에서 진단을 명확히 규정하는데 매우 유용하였다. 일반 NWBCT에 비해 환자의 피폭량은 1/20로 줄일 수 있었고, 촬영 시간도 단축되었다. 결론 : WBCT는 족부의 질환을 진단하는데 NWBCT에 비해 큰 장점이 있었다. 서 있을 때나 보행 시에 통증을 느끼는 환자의 족부 상태를 그대로 영상화 하여 보여줌으로써 진단의 명확성을 높이고 원인을 규명하는데 에도 도움이 되었다. 검사시간 단축과 피폭선량 감소로 환자에 심리적인 불안감을 해소시키고 육체적 안정성을 개선하였으며 장비의 다양한 기능으로 인하여 환자가 편안한 자세로 검사할 수 있었다. Purpose : We want to investigate the usefulness of the Foot and Ankle diagnosis of Weightbearing-Computed-Tomography(WBCT) and functional and structural properties of WBCT equipments. Materials and Methods : We evaluated the diagnostic value of a certain disease thorugh examining the differences between WBCT and Non-Weight-bearing-Computed- Tomography(NWBCT) when we diagnosed with the disease of the patients in the Foot and Ankle clinic. Also, during the WBCT test, we also examined the patient’s convenience and decrease of the radiation dose. Results : Compared to NWBCT, the patient’s state of WBCT could be imaged as it is. Especially, it is useful to make a clear diagnosis of OsteoArthrosis(OA), Flat foot and valgus region. It resulted in that the radiation dose decreased at 5%, and it reduced the time of Acquisition Time of WBCT, than NWBCT. Conclusions : Weight bearing CT had a significant advantage over the Non Weight bearing CT, in the diagnosis of a disease Foot and Ankle. It helps to identify the cause of the disease and improve the accuracy of diagnosis, as it shows all images of the condition of the patients pain in the foot and ankle when they walk and stand. It improves the physical stability and also relieves the anxiety of patients by reduced testing time and dose. The various functions of the equipments get patientsi n a comfortable position.

당뇨병 교육 방법이 당뇨병 환자의 식사요법 수행과 당화혈색소에 미치는 영향

김을상,문현경,이영남,이태훈,김성곤,고재민,손진희,유형준,송오금,남흥우,정성오,위준환,염주협,조대경 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.5

Background: Diet control plays an important role in diabetic management, but it is often hard for diabetic patients to follow the dietary control program. Poor dietary compliance leads to metabolic derangements in patients with diabetes and it may derive mainly from defects in dietary education program rather than from patients themselves. Therefore, we performed a randomized prospective study to compare the effects of three different teaching methods for diet control. Methods: Forty eight diabetic patients with poor glycemic control (mean HbA1c 11.4±1.5%) were enrolled during hospitalization and allocated at random to three different teaching methods i.e. Conventional diet sheet instruction (Group 1), Food recording on every meal (Group 2), and Meal time demonstration (Group 3). For evaluation, knowledge about DM diet and barriers to diet control were assessed by a questionnaire. Consistency in carbohydrate intake (Coefficient of variation) and serial HbA1C measurements were used for the estimation of dietary compliance and glycemic control respectively. Results: During five months' follow-up period, there was no remarkable improvement in knowledge about diabetic diet control, dietary compliance and glycemic control in Group 1 patients. But both dietary compliance and glycemic control improved in Group 2 and 3 patients during follow-up period. In Group 2 CV (Coefficient of Variation) fell from 36.4±15.2% to 27.7±17.3% and in Group 3 from 32.1±9.6% to 23.2±10.5% (p$lt;0.05). In Group 2 HbA_(1c) fell from 12±2.2% to 8.3±2.0% and in Group 3 from 11.5±2.0% to 7.5±1.9%(p$lt;0.01). The change of HbA1c level showed an appreciable correlation with dietary compliance (r= 0.75). Among the perceived barriers to dietary practice in patients of Group 2 and Group 3, extrinsic factors related to knowledge lowered during the intervention (p$lt;0.05). Even though Group 3 patients had good dietary compliance, they still felt that intrinsic factors related to motive and attitude were the major barriers at the end of the study (p$lt;0.05). Conclusion: We found that meal time demonstration teaching method may improve dietary compliance and glycemic control compared with the conventional diet sheet instruction method.

Vulvar skin metastasis of Lung squamous cell carcinoma (초)

( Ji Hoon Sim ),( Han Eul Lee ),( Gun Hong Lee ),( Moon Kyun Cho ),( Young Lip Park ),( Sung Yul Lee ) 대한피부과학회 2011 초록집 Vol.49 No.10

수치해석시뮬레이션을 이용한 문학경기장 지붕구조물의 풍하중 영향 평가

조정훈(Cho Jeong-Hoon),임사랑(Yim Sa-Rang),이경수(Lee Kyung-Soo),한상을(Han Sang-Eul) 대한건축학회 2011 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.31 No.2(구조계)

Recently, the trends in the shape of tall buildings and large span spatial structures can be characterized as freeform shape. Especially, three-dimensional surface structure such as the shells and membrane structures is difficult to apply the wind load due to the complexity of the shape and the thin thickness. According to codes for wind resisting design, The structures which is difficult to calculate wind load, are allowed to perform the wind tunnel experiment or analysis methods. so, In this study, Mun-Hak stadium roof structure of the typical membrane structures was analyzed for the wind pressure characteristic against state of the damaged roof membrane caused by Hurricane Kompas and original state using CFD(Computational Fluid Dynamic).

Voriconazole로 성공적으로 치료한 Scedosporium apiospermum에 의한 피부감염증

조홍기 ( Hong Ki Cho ),이한을 ( Han Eul Lee ),최영진 ( Young Jin Choi ),이상훈 ( Sang Hoon Lee ),황규왕 ( Kyu Uang Whang ),이종석 ( Jong Suk Lee ),이성열 ( Sung Yul Lee ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.2

Scedosporium apiospermum, an asexual state of Pseudallescheria boydii, is a widely distributed mould that can be found in the soil, manure, stagnant water and decaying vegetation. It has become an emerging pathogen among immunosuppressed patients but it can also cause infections in immunocompetent patients by penetrating trauma. This fungus is a classical cause of mycetoma and the localized skin infections caused by this mould are much rarer than mycetoma. We report a case of cutaneous S. apiospermum infection in a 79-year-old woman. She had erythematous plaque with crust and violaceous supprative nodules on the right forearm. The culture from pus showed typical white to gray colored cottony colonies of S. apiospermum. Treatment was started with voriconazole effectively. Skin lesions completely cured with no reccurence. Thus, voriconazole shows to be an effective treatment for Scedosporium infection. (Korean J Dermatol 2013;51(2):135∼139)

Loop-mediated Isothermal Amplification(LAMP)을 이용한 꿀벌의 Black Queen Cell Virus(BQCV) 신속 검출법의 개발

조용호(Yong-Ho Cho),유미선(Mi-Sun Yoo),김을환(Eul-Hwan Kim),이동우(Dong-Woo Lee),김일욱(Il-Wook Kim),강민희(Min-Hee Kang),한상훈(Sang-Hoon Han),윤병수(Byoung-Su Yoon) 한국양봉학회 2007 韓國養蜂學會誌 Vol.22 No.2

The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles

( Jeong-min Ha ),( Cho-ah Lim ),( Kyuboem Han ),( Jong-cheon Ha ),( Hae-eul Lee ),( Young Lee ),( Young-joon Seo ),( Chang-deok Kim ),( Jeung-hoon Lee ),( Myung Im ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.2

Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may of-ten have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort. Objective: We evaluated the efficacy and the safety of soluble micro-spi-cule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles. Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a random-ized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects under-went 8 weeks of follow-up. Efficacy was assessed using an ul-trasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for peri-ocular wrinkles and subjective satisfaction. Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted. Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles. (Ann Dermatol 29(2) 187∼ 193, 2017)