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In Yong Lee,Euh Jun Jeoung,권영근,Jongseon Choe,Jinkoo Kim,Eun-Mi Ko 한국분자세포생물학회 2002 Molecules and cells Vol.14 No.1
The role of interleukin-4 (IL-4) in the inflammatory process has emerged recently. In this study, we investi-gated the effect of IL-4 on the angiogenic process in an in vitro experimental system. IL-4 significantly inhib-ited the proliferation of human umbilical vein endo-thelial cells (HUVEC) that was induced by the vascu-lar endothelial growth factor (VEGF) and basic fibro-blast growth factor (bFGF). VEGF- or bFGF-induced HUVEC chemotaxis was abrogated by the IL-4 treat-ment. In addition, the formation of tube-like struc-tures by HUVEC in the presence of VEGF or bFGF was also severely down-regulated by IL-4. The inhibi-tory effects on the critical steps of angiogenesis were not observed with IL-6 that is abundantly found in the inflamed tissue. Our results suggest that IL-4 may play a regulatory role in normal physiology and provide the potential possibility for IL-4 as a therapeutic agent in the intervention of angiogenesis-related diseases.
Ji Hyun Lee,Ran Young Park,Chang Soo Lee,Euh Jun Jeoung,Su Youn Nam,Jae Gun Lee,Kye-Young Han,Hee-Jae Lee,Joo Ho Chung,Yun Gul Ahn,Sung Vin Yim,Jaeyoung Cho,Yeon Hee Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.6
Purpose: Oxidative stress has been implicated in thepathogenesis of various diseases. Catalase is one ofthe main defense mechanisms against oxidativestress. To exam ine the possible relationship betweenoxidative stress, and gastric and hepatocellular carcinomas,HinfI restriction length polymorphism (RFLP)in the human catalase gene was assessed.Materials and Methods: The genotype and allelefrequencies in the promoter region of the catalasegene were studied by PCR-RFLP in 108 Koreancontrols, 80 Korean gastric carcinoma (GC) and 106Korean hepatocellular carcinoma (HCC) patients.Results: No statistically significant differences werefound in the genotypic distribution and allelic frequenciesbetween the controls and both types ofcarcinoma patient.Conclusion: To address the possible contribution ofoxidative stresses to the pathogenesis of gastric andhepatocellular carcinomas, the associations betweenthe catalase gene polymorphism and GC and HCCsusceptibilities were studied. As a result, the catalasegene polymorphism was found not to be determinantof GC and HCC susceptibilities. Further studies arerequired on various other oxidative stress relatedgenes to elucidate the mechanisms of GC and HCC.(Cancer Res Treat. 2002;34:432-435)