http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
It Sometimes Happens: Staging Surgery in Coexisting Graves' Disease and Thyroid Cancer
Ettore Caruso,Maria De Pasquale,Antonella Pino,Vincenzo Bartolo,Fausto Famà,Gianlorenzo Dionigi 대한갑상선-내분비외과학회 2019 The Koreran journal of Endocrine Surgery Vol.19 No.3
Thyroidectomy is a safe procedure often performed either for benign or malignant thyroid diseases. Complication rate is low and bilateral recurrent laryngeal nerve (RLN) injury associated with thyroidectomy is rarely described. The RLN may be injured bilaterally and damage is usually recognized postoperatively. With an increased use of intraoperative neural monitoring (IONM), an adaptation of the resection strategy appears to be necessary in case of an intraoperative loss of signal of the first operated side with total thyroidectomy planned. We review a case of a 21-year-old female with a history of Graves' disease who underwent a total thyroidectomy in a 2-stage procedure due to a loss of RLN function detected intraoperatively. The patient recovered uneventfully from the 2 surgeries.
Efficacy of Percutaneous Thermal Ablation of Papillary Thyroid Carcinoma
Ettore Caruso,Ettore Gagliano,Gianlorenzo Dionigi 대한갑상선-내분비외과학회 2019 The Koreran journal of Endocrine Surgery Vol.19 No.4
Percutaneous thermoablation (PTA) has become an increasingly used option in the interventional treatment of symptomatic, cytologic and sonographic benign solid thyroid gland disease. Currently, there is no high-level evidence of treatment for differentiated thyroid cancer by means of PTA. Surgery is a standard treatment for primary and also for recurrent thyroid cancer, followed by radioactive iodine and thyroid hormone therapy. PTA, however, can be used in patients at high-risk and in patients who refuse to undergo repeated surgery. The Task Force Committee of the Korean Society of Thyroid Radiology has developed recommendations for the optimal use of PTA for thyroid nodules. However, there are still several questions on safe distance to the laryngeal nerves, no data on duration of PTA application around the nerves, no intra-procedure assessment of laryngeal nerves function and position. Future experimental studies are required.
Preoperative Treatment with Lugol Solution for Graves' Disease
Özer Makay,Hui Sun,Ettore Caruso,Antonella Pino,Alessandro Pontin,Tommaso Mandolfino,Gianlorenzo Dionigi 대한갑상선-내분비외과학회 2019 The Koreran journal of Endocrine Surgery Vol.19 No.4
Graves' disease is one of the commonest causes of hyperthyroidism. Pre-treatment with Lugol solution, containing iodine/potassium iodide, to induce euthyroidism before surgery may be suggested, especially in case of adverse events due to antithyroid medication. Whether post-operative outcomes are any different following a course of Lugol solution in patient with Graves' disease is not well-documented in the literature. It is definite that large, prospective, randomized controlled trials of clinical and scientific are warranted to answer whether or not preparation with Lugol solution is necessary prior to surgery for Graves' disease.
What You Need to Know about Mental Nerve Surgical Anatomy for Transoral Thyroidectomy
Antonella Pino,Andrea Parafioriti,Ettore Caruso,Maria De Pasquale,Paolo Del Rio,Pietro Giorgio Calò,Gianlorenzo Dionigi,Francesco Stagno d'Alcontres 대한갑상선-내분비외과학회 2019 The Koreran journal of Endocrine Surgery Vol.19 No.4
Gian Carlo Tenore,Domenico Caruso,Giuseppe Buonomo,Maria D’Avino,Rita Santamaria,Carlo Irace,Marialuisa Piccolo,Maria Maisto,Ettore Novellino 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.1
Several pharmaceutical products have been formulated over the past decades for the treatment of male and female alopecia, and pattern baldness, but relatively few metadata on their efficacy have been published. For these reasons, the pharmaceutical and medical attention has recently focused on the discovery of new and safer remedies. Particularly, great interest has been attracted by oligomeric procyanidin bioactivity, able to promote hair epithelial cell growth as well as to induce the anagen phase. Specifically, the procyanidin B2, a dimeric derivative extracted from apples, has demonstrated to be one of the most effective and safest natural compounds in promoting hair growth, both in vitro and in humans by topical applications. By evaluating the polyphenolic content of different apple varieties, we have recently found in the apple fruits of cv Annurca (AFA), native to Southern Italy, one of the highest contents of oligomeric procyanidins, and, specifically, of procyanidin B2. Thus, in the present work we explored the in vitro bioactivity of AFA polyphenolic extract as a nutraceutical formulation, named AppleMets (AMS), highlighting its effects on the cellular keratin expression in a human experimental model of adult skin. Successively, testing the effects of AMS on hair growth and tropism in healthy subjects, we observed significant results in terms of increased hair growth, density, and keratin content, already after 2 months. This study proves for the first time the impact of apple procyanidin B2 on keratin biosynthesis in vitro, and highlights its effect as a nutraceutical on human hair growth and tropism.
Gian Carlo Tenore,Domenico Caruso,Giuseppe Buonomo,Maria D’Avino,Pietro Campiglia,Luciana Marinelli,Ettore Novellino 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.3
Cardiovascular diseases are nowadays preferential targets of preventive medicine through a straightforward therapy on lipid profile. However, statins, the first-line lipid-lowering drug therapy, specifically act on low-density lipoprotein cholesterol (LDL-C), having a modest effect on plasma high-density lipoprotein cholesterol (HDL-C) concentrations. Today, a number of novel HDL-targeted therapies are emerging, along with unexpected side effects. Thus, novel and possibly safe substances, able to correct impaired lipid profile in humans, are still in great demand. Herein, based on encouraging clinical data, we formulated a nutraceutical product (AppleMetS®, AMS), based on a polyphenolic extract from Annurca apple, and demonstrated that two capsules a day of AMS, after one month, have a LDL-C lowering outcome equivalent to 40 mg of simvastatin or 10 mg of atorvastatin. Nevertheless, different from statin-based therapy, AMS exerted a notable effect on HDL (+49.2%). Based on the trial results, we can assert that AMS formulation could effectively integrate the current therapeutic arsenal to correct impaired lipid profile in humans. Specifically, AMS may be considered a complementary and/or alternative safe substance suitable for the treatment of mildly hypercholesterolemic subjects who do not present occurrence of atheromatous plaques yet.
Venous Thromboembolism Following Thyroid Surgery
Özer Makay,Hui Sun,Alessandro Pontin,Ettore Caruso,Antonella Pino,Tommaso Mandolfino,Gianlorenzo Dionigi 대한갑상선-내분비외과학회 2019 The Koreran journal of Endocrine Surgery Vol.19 No.4
Venous thromboembolism is viewed as a serious health care issue. Patients who experience venous thromboembolism often have an detoriorated quality of life after the event that may require anticoagulation. This results to the risks of spontaneous bleeding. Bleeding after thyroid surgery can present acutely and can lead to airway compromise and death if not recognized and treated appropriately. Whether prophylaxis in a low-risk patient puts the patient at a greater risk of developing a bleeding complication is not well documented. The literature is scarce regarding the prevalence of venous thromboembolism following thyroid and parathyroid surgery.