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Leandro dos Santos,Leticia de Oliveira Maciel,Erika Kristina Incerpi Gracia,Evelise Aline Soares,Danielle Aparecida Quintino Si,Valerio Garrone Barauna,Heder Frank Gianotto Estrela,Carollayne Mendonca 한국식품영양과학회 2021 Preventive Nutrition and Food Science Vol.26 No.1
Cardiovascular diseases are the leading cause of mortality and morbidity worldwide. In this study we compared the effects of oral treatment with red pepper ethereal extracts or simvastatin on dyslipidemia, left ventricle remodeling, and atherosclerotic lesions of low-density lipoprotein (LDL) receptor knockout mice (LDLr<SUP>−/−</SUP>) fed a hyperlipidic diet. Forty 3-month-old male mice were distributed into four groups: control (C; animals fed a standard diet), HL (animals fed a hyperlipidic diet), and HL+P or HL+S (animals fed a hyperlipidic diet plus red pepper ethereal extracts or simvastatin, respectively). After 60 days, treatment with both red pepper ethereal extracts and simvastatin prevented dyslipidemia, atherosclerotic lesion progression, and left ventricle hypertrophy. Our results suggest a cardioprotective effect of red pepper ethereal extracts in LDLr<SUP>−/−</SUP> mice, which is comparable to the well-known effects of simvastatin.
Marcelo de Oliveira, Santos,Albuquerque de Barros, Erika Valeria Saliba,Penha Tinoco, Maria Laine,Miranda Brasileiro, Ana Cristina,Lima Aragao, Francisco Jose The Korean Society of Plant Biotechnology 2002 Plant molecular biology and biotechnology research Vol.4 No.2
In order to achieve repetitive somatic embryogenesis in cacao (Theobroma cacao L.), callus derived from floral tissues were continuously cultured in a medium containing 2,4-D. In 5% of the explants, repetitive somatic embryogenesis was observed after 8 weeks and maintained in a globular stage for several weeks. This is the first report showing repetitive somatic embryogenesis in cacao. The calli were bombarded with a plasmid containing $\beta$-glucuronidase (gus) as reporter gene. Two week old calli showed the high average number of cells expressing the us gene. The effect of osmotic agents (mannitol, sorbitol and sucrose) on gene expression was evaluated. Pre-treatment during 16 h with 0.25 M mannitol revealed an improvement in gene expression. The potential utilization of the repetitive embryogenesis, combined with osmotic treatment, is discussed as an alternative to achieve stable transgenic cacao plants.
Thaynã Ramos Flores,Ana Paula dos Santos Rodrigues,Rosália Garcia Neves,Sandro Rodrigues Batista,Doralice Severo da Cruz Teixeira,Erika Aparecida da Silveira,Deborah Carvalho Malta,Bruno Pereira Nunes 대한비만학회 2021 The Korean journal of obesity Vol.30 No.2
Background: An increase in body mass index (BMI) is strongly associated with the occurrence of multimorbidity, and overweight and obesity are contributing factors for the increase in morbidities. Thus, the present study aimed to evaluate the occurrence of multimorbidity and associated factors in Brazilian adults with and without overweight or obesity. Methods: This was a cross-sectional population-based study with data from the National Health Survey (2013) including individuals aged 18 years or older. Multimorbidity was defined as having ≥2 diseases from the list of 15 morbidities on the self-reported questionnaire (self-reported medical diagnosis in life). BMI was categorized as: ≤24.9 kg/m2 (low weight and eutrophy), 25.0–29.9 kg/m2 (overweight), and ≥30.0 kg/m2 (obesity). Sex, age, and schooling were the covariates. Poisson regression was used for crude and adjusted analyses for the variables representing access to health services estimating the prevalence ratio (PR) and 95% confidence interval (CI). Results: The total sample consisted of 59,402 individuals. The prevalence of multimorbidity was 25% overall and was higher among overweight (25.8%) and obese (32.5%) individuals. Obese women 60 years or older had a higher occurrence of multimorbidity (80%). In the adjusted analysis, a lower prevalence of multimorbidity was observed among those with higher educational levels in all BMI classifications: low weight/eutrophy, PR=0.66 (95% CI, 0.58–0.75); overweight, PR=0.62 (95% CI, 0.56–0.70); and obesity, PR=0.75 (95% CI, 0.67–0.85). Conclusion: A higher prevalence of multimorbidity was found among obese women who were 60 years of age or older. Schooling was an associated factor regardless of BMI.
( Carolina Rodrigues Mendonça ),( Matias Noll ),( Annelisa Silva E Alves De Carvalho Santos ),( Ana Paula Dos Santos Rodrigues ),( Erika Aparecida Silveira ) 대한통증학회 2020 The Korean Journal of Pain Vol.33 No.3
Background: Musculoskeletal pain is associated with obesity; however, information on factors associated with pain in adults with obesity and severe obesity is limited. The purpose of this study was to assess the prevalence of musculoskeletal pain by site and intensity of pain and associated factors in individuals with severe obesity (body mass index ≥ 35.0 kg/m<sup>2</sup>). Methods: Baseline data from the DieTBra Trial study evaluating pain symptoms in nine body regions over the last seven days using the Nordic Questionnaire on Musculoskeletal Symptoms and Numerical Pain Scale. The variables analyzed using multiple Poisson regression with hierarchical analysis were: sociodemographic, lifestyle, food consumption, clinical, and anthropometric, and the outcome was moderate and intense pain. Results: In 150 participants, there was a high prevalence of ankle and foot pain (68.7%), lower back pain (62.7%), pain in the knees (53.3%) and upper back pain (52.0%), with a predominance of intense pain. Factors associated with pain according to specific sites were: type 2 diabetes with hand/wrist pain; sedentary time with hip pain; insomnia with pain in the hip and knee; edema in the lower limbs with pain in the lower back and ankles/feet; degree of obesity with ankle/foot pain; and percentage of total fat with ankle/foot pain. Conclusions: There was a high prevalence of pain and intense pain in individuals with severe obesity and an association with clinical variables, the degree of obesity, and sedentary lifestyle.