Clinical Course and Results of Surgery for Chronic Subdural Hematomas in Patients on Drugs Affecting Hemostasis

Dziedzic, Tomasz Andrzej,Kunert, Przemyslaw,Marchel, Andrzej The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.2

Objective : An apparent increase of use of drugs affecting hemostasis in our neurosurgical department since the 1990s has encouraged us to investigate whether these drugs influence the clinical course and results of surgery for chronic subdural hematoma (CSDH). Methods : This retrospective analysis included 178 patients admitted for CSDH from 2007 to 2011 who were divided into two groups : on drugs affecting hemostasis (40; 22%) and no bleeding disorders (138; 78%). Medications in the first group included oral anticoagulants (33; 82.5%), antiplatelets (5; 12.5%) and low molecular weight heparins (2; 5%). Results : The patients on drugs affecting hemostasis were older ($74.3{\pm}7.4$ vs. $68.4{\pm}14.8$; p-value 0.01) and the group without bleeding disorders had more head trauma history (61% vs. 38%, p-value 0.01). The groups did not differ in bilateral hematoma rates (25% vs. 20%, p-value=NS). At diagnosis, mean hematoma thickness was lower in patients on drugs affecting hemostasis ($18.7{\pm}7.4mm$ vs. $21.9{\pm}7.9mm$, p-value<0.01). Average stay of hospital was 1 day longer in patients on drugs affecting hemostasis ($11.7{\pm}4.1$ vs.$10.9{\pm}5.3$, p-value=NS) and was related to the necessity of bleeding disorder reversal. Mean neurological status at presentation was similar between the groups (p-value=NS) as was the likelihood of hematoma recurrence (p-value=NS). Glasgow Outcome Scale results were comparable. Conclusion : Patients on drugs affecting hemostasis are less often aware of a head trauma history, possibly suggesting a higher CSDH risk after minor trauma in this group. In these patients, smaller hematomas are symptomatic, probably due to faster hematoma formation. Drugs affecting hemostasis do not affect treatment results.

Long-Term Management of Seizures after Surgical Treatment of Supratentorial Cavernous Malformations : A Retrospective Single Centre Study

Dziedzic, Tomasz A.,Koczyk, Kacper,Nowak, Arkadiusz,Maj, Edyta,Marchel, Andrzej The Korean Neurosurgical Society 2022 Journal of Korean neurosurgical society Vol.65 No.3

Objective : Seizure recurrence after the first-ever seizure in patients with a supratentorial cerebral cavernous malformation (CCM) is almost certain, so the diagnosis and treatment of epilepsy is justified. The optimal method of management of these patients is still a matter of debate. The aim of our study was to identify factors associated with postoperative seizure control and assess the surgical morbidity rate. Methods : We retrospectively analysed 45 consecutive patients with a supratentorial CCM and symptomatic epilepsy in a single centre. Pre- and postoperative epidemiological data, seizure-related patient histories, neuroimaging results, surgery details and outcomes were obtained from hospital medical records. Seizure outcomes were assessed at least 12 months after surgery. Results : Thirty-five patients (77.8%) were seizure free at the long-term follow-up (Engel class I); six (13,3%) had rare, nocturnal seizures (Engel class II); and four (8.9%) showed meaningful improvement (Engel class III). In 15 patients (33%) in the Engel I group; it was possible to discontinue antiepileptic medication. Although there was not statistical significance, our results suggest that patients can benefit from early surgery. No deaths occurred in our study, and mild postoperative neurologic deficits were observed in two patients (4%) at the long-term follow-up. Conclusion : Surgical resection of CCMs should be considered in all patients with a supratentorial malformation and epilepsy due to the favourable surgical results in terms of the epileptic seizure control rate and low postoperative morbidity risk, despite the use of different predictors for the seizure outcome.

Evaluation of sweet cherry fruit quality after short-term storage in relation to the rootstock

Ewa Dziedzic,Jan Błaszczyk 한국원예학회 2019 Horticulture, Environment, and Biotechnology Vol.60 No.6

Fruits of the sweet cherry cultivar ‘Regina’ collected from trees growing on seven rootstocks were stored in a cold room at 2 °C with a normal (NA) and controlled atmosphere (15% and 20% CO2 and 5% O2—CA1 and CA2) for 2 weeks. The rootstocks on which the trees grew and the storage conditions significantly affected all fruit parameters tested during both years of the experiment. Fruit from Damil rootstock exhibited higher mean firmness than fruit from Colt rootstock. The effect of rootstocks on the value of soluble solids content (SSC) varied, wherein the fruits from Tabel Edabriz and Damil were characterized by high SSC mean content. The organic acids content (TA) was significantly lower after storage than during harvest time. Fruits from Tabel Edabriz trees were characterized by faster ripening, as was evident by the higher SSC to TA ratio. The amount of mass lost depended significantly and only on the storage conditions—sweet cherries from both CA combinations had the lowest mass losses. The percentage of fruits showing disease symptoms was largely dependent on the weather conditions in the orchard the year before the fruit harvest, as well as atmosphere composition and RH during fruit storage. Cold storage conditions with a high (20%) CO2 content are recommended for the short-term storage of sweet cherry fruits because they preserve fruit quality parameters: a low decrease in firmness, maintenance of a high SSC/TA ratio, a low percent of fungal infections, and good preservation of green color in the peduncle.

Interactions between fecal bacteria, bile acids and components of tomato pomace

Krzysztof Dziedzic,Danuta Go´recka,Agnieszka Dro_zd_zyn´ska,Artur Szwengiel,Jan Michniewicz,Jarosław Walkowiak 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.3

The tomato pomace obtained during processingas a residue of tomato processing from large industry. Theinteractions between tomato pomace and fecal bacteria,bile acids during in vitro digestion were studied. Digestionwas carried out by using bioreactor in anaerobic conditions. Tomato pomace can significantly affect the count of fecalbacteria and the solubility of bile acids in in vitro digestiondue to bonding ability of their proteins/peptides. Theavailability and use of bile acids does not only depend onthe interactions between bile acids and bacteria, but alsothe interactions of bile acids with digested food components. Tomato pomace characterized high dietary fibercontent and its fractions: 17.64–21.53% for cellulose and13.48–18.63% for lignin. Given our results we supposedthat fecal bacteria can use primary bile acids, as theirsource of energy in an environment where carbon availabilityis limited.

The Effect of Ozone Inhalation on the Thymus and Mediastinal Lymph Nodes of CD-1 Mice

Daniel Dziedzic,Harold J.White 한국자동차공학회 1987 한국자동차공학회 학술강연초록집 Vol.- No.-

Biological features of fl owers infl uence the fertility of Lonicera spp. Cultivars

Monika Bieniasz,Ewa Dziedzic,Gerard Słowik 한국원예학회 2019 Horticulture, Environment, and Biotechnology Vol.60 No.2

Fertility experiments were carried out on a plantation of haskap berries (40 cultivars) in southern Poland. Based on theobservation of phenological phases, the cultivars were divided into three groups with similar overlapping periods of fullfl owering: the earliest comprising 11 cultivars; the moderate-early, 17 cultivars; and the latest, 7 cultivars. The attractivenessof cultivars for pollinating insects was evaluated on the basis of fl ower biometric measurements. Flowers are more diversein length than in width of the sympetalous corolla, with the pistil always being longer than the corolla, which is conduciveto eff ective insect pollination. A pollen viability coloring test and germination capacity on agar medium were used to assesspollen quality. Despite very high pollen viability (on average, 90%), the percentage of germinating pollen was very low andranged from 3.3 to 34.5%. Pollen yields for each cultivar were calculated based on the number of pollen grains in the fl owers. The cultivars diff ered signifi cantly in terms of the number of pollen grains in the fl owers. The cultivar “Morena” wascharacterized by the highest number of pollen grains (45,375), while the cultivar “Fialka” had the lowest (2750). Microscopicobservations of pollen tube overgrowth through the style of the pistil after open pollination and self-pollination allowedfor calculation of the pollen germination index (PGI) used to assess the fertility of the cultivars. Self-pollinated cultivarswith a PGI < 2 were characterized by self-incompatibility. It was found that among the 40 cultivars studied, only the “DoczVelikana” cultivar exhibited PGI > 2, which proves the self-fertility tendency of this cultivar.