Alteration of antioxidant enzyme activites of L1210 cells by CM-2 fractions of Artemisia argyi

DY Jung,HK Ha,AN Kim,SW Park 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.2004 No.1

The Overexpression of Insulin-siRNA and Insulin Degrading Enzyme Decreases Insulin Levels In vitro and In vivo

DY Hwang,JH oh,YK Kim,SB Shim,SW Jee,SH Lee,SJ Seo,YS Song,KT Nam,JY Cho,Jane Hwang,IS Jang,JS Cho 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2

Type 2 or noninsulin-dependent diabetes mellitus accounts for over 90% of cases and is characterized by a triad of resistance to insulin action on glucose uptake in peripheral tissues, impaired insulin action to inhibit hepatic glucose production, and dysregulated insulin secretion. To determine whether a transgene-based small interfering RNA (siRNA) for insulin and an overexpression of human insulin degrading enzyme (hIDE) decrease the insulin level in vitro and in vivo or not, several siRNA sequences and hIDE gene for insulin were overexpressed in the insulinoma cells and mouse via tail vein. The siRNAs for insulin suppression were very effective at the regions of 88-99 bp and 109-131 bp in rat insulin sequence. Insulin suppression by the specific siRNA sequences and hIDE significantly induced endoplasmic reticulumn (ER) stress and decreased insulin receptor a expression in insulinoma cells. The insulin level in plasma significantly decreased by overexpressions of the siRNAs and hIDE gene in mouse, which may be caused by the degradation of insulin due to overexpression of hIDE protein in mouse liver. These results suggest that this plasmid for the suppression of insulin secretion by the specific siRNAs and the insulin degradation by an overexpression of hIDE protein may be useful on the development of animal model for Type 2 diabetes.

Aberrant Phenotypes of Alzheimer's Disease in Doubly Transgenic Mice

DY Hwang,JS Cho,JH Oh,SB Shim,SW Jee,SH Lee,SJ Seo,HJ Lim,SH Min,YS Song,HK Park,IS Jang,YK Kim 한국실험동물학회 2004 한국실험동물학회 학술발표대회 논문집 Vol.2004 No.-

임신5개월의 흔적자궁 파열 1례

윤대영(DY Yun),문시영(SY Moon),김상갑(SK Kim),박정근(JK Park) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.2

부산 성분도병원 산부인과에서 경험한 18세의 미산부에 발생한 18주의 흔적자궁임신 례를 보고하며 간단한 문헌고찰을 하였다. A case of rupture of rudimentary uterine horn with 18 weeks gestation which was diagnosed as a intra-abdominal pregnancy is presented and some articles are reviewed briefly.

자궁경관점액에 함유된 단백질의 정양분석에 관한 연구

고덕영(DY Ko) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.6

The following results were obtained: 1) Contents of Albumin per Gm of cervical mucus were: non pregnant group Proliferative phase 2.40_+1.15mg/Gm C.M. ovulatory phase 2.91_+1.83 " secretory phase 3.62_+1.84 " average 3.12_+1.79 " Pregnant group first half 3.41_+2.73mg/Gm C.M. latter half 4.34_+1.76 " average 4.20_+1.60 " Mean of bouth groups 3.30_+1.78 " 2) Contents of IgG per Gm of cervical mucus were: non pregnant group Proliferative phase 1.50_+1.00mg/Gm C.M. ovulatory phase 2.31_+2.38 " secretory phase 2.40_+1.48 " average 2.06_+1.54 " Pregnant group first half 2.40_+1.70mg/Gm C.M. 자궁경관점액에 함유된 단백질의 정양분석에 관한 연구... latter half 4.99_+3.07 " average 4.15_+2.53 " Mean of bouth groups 2.51_+1.88 " 3) Contents of IgA per Gm of cervical mucus were: non pregnant group Proliferative phase 1.21_+0.80mg/Gm C.M. ovulatory phase 0.94_+0.64 " secretory phase 2.60_+1.66 " average 1.54_+1.04 " Pregnant group first half 2.53_+1.87mg/Gm C.M. latter half 2.94_+2.38 " average 2.70_+2.04 " Mean of bouth groups 1.70_+1.27 " 4) Three (Albumin, IgG & IgA) values showed all increasing tendency in pregnant group more than non pregnant group, difference being most significant in the values of albumin and IgG(p < 0.02). 5) Among the non pregnant groups, all the three values showed in increaing amounts in the following order proliferative, ovulatory, and secretory phases, significant differences being noted between proliferative and secretory phases (albumin & IgA), and between ovulatory and secretory phases (IgA) (p < 0.02). 6) Among pregnant groups, all the three values were also more increase in the first half priod than the latter half, difference being significant in the IgG value (p < 0.02). 7) The possible role of the immunoglobulins of the cervical mucus in immunological function of the female genital organs was discussed in relation with the fact that secretion of immunoglobulins into cervical mucus was increased in the post-ovulatory phase and the latter half period of gestation. In recent years considerable interest has been focused on the role of cervical secretion in the biologic or immunologic infertility, microbiology, exfoliative cytology, and immunologic oncology of the female genital organs. However, the exact details of the composition, properties, and role of this cervical mucus remain still obscure. It is of fundamental importance to determine and denote the individual protein components of cervical mucus to understand its properties and role. Recently some authors reported the presence and identification of several serum fractions, including albumin, gamma globulin, two alpha-2 globulin, three beta-1 globulin, and two beta-2 globulins, and prealbumin, in the normal cervical mucus by means of agar gel electrophoresis and immunoelectrophoresis. The objective of this paper is to observe the changes of the contents of individual protein fractions in the cervical mucus according to each phase of menstrual cycle and each period of pregnancy. For this purpose the sensitive and specific technique of Oudin`s capillary tube agar diffusion method has been employed on 120 cases of non pregnant group-36 cases of proliferative phase, 30 cases of ovulatory phase and 54 cases of secretory phase-and 51 cases of pregnant group-27 ceses of the earlier half and 24 cases of the latter half of gestation period. As an eluting buffer solution of the solid cervical mucus. 0.02M sodium phosphate-0.5M Saline buffer was used to make serum proteins contained in the cervical mucus into soluble proteins. Specific antiserum and standard serum Albumin, IgG and IgA were supplied by Hyland Laboratory. The capillary tubes used were Kimax and Scientific Products.

뇌복수를 동반한 점액성난소배선암의 1예

정두용(DY Chung),길운형(WH Kil),최숙희(SH Choi),강영호(YH Kang) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.3

결론 저자들은 최근 19세의 처녀에서 발생한 뇌·복수가 동반된 점액성 난소배선암을 적출후 뇌·복수가 자연 소실된 예를 경험 하였기에 간단한 문헌적 고찰과 함께 보고하는 바이다. Since the first description of the syndrome of ascites and hydrothorax associated with benign ovarian fibroma by Meigs in 1937, many other tumors have been found that produce this syndrome. Ascites and pleural effusions without gross or cytologic eⅵdence of metastasis have been noted to disappar with removal of the original neoplasms in the malignant as well as benign pelⅵc tumors. we report a case of ovarian mucinous cystadenocarcinoma associated with ascites and hydrothorax in a 19-year-old ⅵrgin with brief reⅵew of the literatures.

신생아제대 Hernia 1예

소달영(DY Soh) 대한산부인과학회 1965 Obstetrics & Gynecology Science Vol.8 No.7

저자는 분만예정일이 8일이 지난 신생아남아에 대소장장기를 내용으로 하는 제대의 hernia 1예를 보고하고 약간의 고찰을 해보았다. A case of umbilical hernia of male infant is reported, and a brief rewiew an the literature is made.

Ritodrine 이 신생아 혈당값에 미치는 영향

노덕영(DY Ro),이충훈(CH Lee),이종건(CK Lee),나종구(JG Na),김수평(SP Kim),이헌영(HY Lee),성인경(IK Sung),이병철(BC Lee),조성훈(SH Cho) 대한산부인과학회 1988 Obstetrics & Gynecology Science Vol.31 No.11

저자들은 ritodrine이 신생아 탄수화물 대사에 미치는 영향을 알아보고져 ritodrine주입을 받은 모성에서 태어난 신생아 40예를 실험군으로 그리고 ritodrine주입이 없었던 모성에서 태어난 신생아 18예를 대조군으로하여 다음과 같은 결론은 얻었다. 1. 실험군과 대조군간에는 성비, 임신주수, 신생아체중, 1분, 5분 Apgar score, 분만통의 유 무, 제왕절개술 빈도에서 유의한 차이가 없었다. 2. 혈당값은 실험군에서 37.9±2.4 ml/dl 대조군에서 63.1±13.0 ml/dl 로 두군간에는 통계적으 로 유의한 차이가 없었다. 3. 저혈당증의 발생빈도는 실험군 40예중에서 9예 대조군 18예중 2예에서 발생하여 두 군간 에는 P value 0.06으로 통계적으로 유의성은 없었다. 그러나 저혈당의 임상증상을 보인 3예 는 모두 실험군에서 발생하였다. 4. 실험군 혈당값중에서 질식분만 예들은 43.3±4.8 mg/dl, 분만통을 갖고 제왕절개술한 예들 에서 36.3±15.0 mg/dl 분만통없이 제왕절개술한 예들에서 35.9±2.7 mg/dl엿으며 각군간에 혈당값은 유의한 차이가 없었다. In order to assess the effect of ritodrine on neonatal carbohydrate metabolism the sugar levels of the neonate delivery by ritodrine treated women were compared with those of the neonate delivery by non-treated women The results were as follows; 1. There was no significantly difference in sex ratio, gesational age, birth weight 1-minute and 5-minute Apgar score the presence of labor and the number of cesarean section delivery between these two groups. 2. The sugar levels were 37.9±2.4 mg/dl in experimental group and 63.1±13 mg/dl in control group . But there was no significantly difference 3. The hypoglycemia occured in 9 of 40 cases of experimental group and 2 of 18 cases of control group , respectively. But there was no significantly difference. All of the symptomatic hypoglycemic cases (3cases) occured in the experimental group . 4. In the experimental group , the blood sugar levels of vaginal delivery group , cesarean section with labor group and cesarean section without labor group were 43.3±4.8 mg/dl, 36.3±15.0 mg/dl and 35.9±2.7 mg/dl ,respectively. There was no significantly difference in each other.

Management of gastric lymphoma with chemotherapy alone

Oh, DY,Choi, IS,Kim, JH,Rhu, MH,Kim, TY,Heo, DS,Bang, YJ,Kim, NK Taylor Francis 2005 Leukemia & lymphoma Vol.46 No.9

<P>Purpose . The optimal therapy for gastric lymphoma except MALToma has not yet been established. This study was undertaken to investigate whether gastric lymphoma can be managed effectively and safely with chemotherapy alone. Patients and methods . A total of 58 patients (median age 56 years) with newly diagnosed gastric lymphoma between 1989 – 2001 at Seoul National University Hospital and who were initially managed with chemotherapy alone were evaluated. MALToma was excluded from the pathologic review. Results . All patients received initially anthracycline-containing chemotherapy. ECOG performance scale 0 – 1 was 88% and B symptoms were present in 41.4%. Diffuse large B cell type was the most common (74.1%). Stage IE, II1E accounted for 51.7% and II2E, IIIE, IV for 48.3%. The international prognostic index (IPI) of risk was low in 39.7%, low-intermediate in 22.4%, high-intermediate in 15.5% and high in 22.4%. The complete response rate after first-line chemotherapy was 71.4% and the partial response rate was 12.2%. (overall response rate: 83.6%). Among patients who did not reach the complete response, a further complete response was achieved by second-line chemotherapy including etoposide-based regimen. Ultimately, the maximum complete response rate by chemotherapy was 83.7% (92% in stage IE, II1E, 75% in stage II2E, IIIE, IV). Median overall survival was 47.4 months (84.7 months in stage IE, II1E, 32.5 months in stage II2E, IIIE, IV) and the 5-year survival rate was 46%. Bleeding as a complication occurred in 3 of 58 patients (5.6%) and these cases were controlled by embolization or conservative management. No perforation episode occurred and surgical intervention due to complication was not necessary. Organ preservation was possible in 57 of 58 patients (98%). The one gastrectomy was performed due to a partial clinical response to chemotherapy but the specimen showed pathologic CR. Multivariate analysis revealed that only IPI had a significant influence on survival. Conclusions . Gastric lymphoma except MALToma can be managed effectively and safely with chemotherapy alone.</P>

자궁근종에서 발생한 자궁평활근육종의 1예

이두용(DY Lee),김영주(YK Kim),천대자(DJ Chun) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.12

Very rare case of sarcomatous change of uterine myoma of uterus observed in 69 year-old infertile housewife. Presenting an unusual case of leiomyosarcoma originating from uterine myoma found postoperatively, with a brief review of the literature available.